Subclasses of monoclonal (type I) immunoglobulin G cryoglobulins : 2 report on two distinct cases with myeloma 3 4 - Archive ouverte HAL Access content directly
Journal Articles Clinical Laboratory Year : 2018

Subclasses of monoclonal (type I) immunoglobulin G cryoglobulins : 2 report on two distinct cases with myeloma 3 4

Sous-classes d'IgG des cryoglobulines monoclonales (type I): à propos de deux cas avec myélome

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Abstract

BACKGROUND: While different clinical manifestations of IgM and IgG monoclonal cryoglobulins have been demonstrated, little is known about the roles of IgG subclasses in the pathophysiology of these conditions. METHODS: In two cases of myeloma-associated monoclonal (type I) cryoglobulinemia with quite distinct clinical and biological features, serum samples were analyzed using an original IgG subclass-specific immunoblotting technique. RESULTS: The first case had painful arthritis of hands and feet, with skin purpura and a sharp decrease of complement C4 level, and the cryoglobulin was of IgG1 subclass. The second case displayed mostly thrombotic lesions of the limb extremities, C3 and C4 serum levels were normal, and the cryoglobulin belonged to the IgG2 subclass. CONCLUSIONS: Type I cryoglobulins of distinct IgG subclasses may result in different syndromes. In both cases, the treatment relies on eradication of the underlying plasma cell dyscrasia.
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Dates and versions

inserm-01826683 , version 1 (29-06-2018)

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Tania Petersen, Sébastien Rivière, Stéphanie Malbos, Yannick Chantran, Aïcha Abbas, et al.. Subclasses of monoclonal (type I) immunoglobulin G cryoglobulins : 2 report on two distinct cases with myeloma 3 4. Clinical Laboratory, 2018, 64 (4), pp.615-618. ⟨10.7754/Clin.Lab.2017.171043⟩. ⟨inserm-01826683⟩
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