L'angiogenèse tumorale Quand l'arbre de vie tourne mal

Abstract : Angiogenesis is a highly controlled multistep process that allows the formation of a harmonious vascular network during embryonic development and in adults. In addition, tumor progression also involves a dedicated blood vessel supply to fuel the tumor mass, pirating physiological molecular and cellular mechanisms. However, tumor angiogenesis is a quite inefficient process, as perfusion is not optimal, vessel integrity is not guaranteed, and vessel network is irrationally organized. While fundamental molecular and cellular mechanisms have been the field of intense investigation, anticancer therapies have evolved with the possibility to target tumor angiogenesis. This review presents the different steps involved in the formation of normal and tumor angiogenesis, and how tumor vasculature abnormalities could contribute to tumorigenesis and conventional therapy failure.
Document type :
Journal articles
Complete list of metadatas

Cited literature [30 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01819799
Contributor : Elizabeth Bernardo <>
Submitted on : Thursday, June 21, 2018 - 8:46:58 AM
Last modification on : Thursday, April 11, 2019 - 4:02:19 PM
Long-term archiving on: Tuesday, September 25, 2018 - 12:46:15 AM

File

medsci20153111p989.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Lucas Treps, Julie Gavard. L'angiogenèse tumorale Quand l'arbre de vie tourne mal. médecine/sciences, EDP Sciences, 2015, 31 (11), pp.989 - 995. ⟨10.1051/medsci/20153111013⟩. ⟨inserm-01819799⟩

Share

Metrics

Record views

119

Files downloads

141