Age-related clinical and biological features of PTEN abnormalities in T-cell acute lymphoblastic leukaemia - Archive ouverte HAL Access content directly
Journal Articles Leukemia Year : 2017

Age-related clinical and biological features of PTEN abnormalities in T-cell acute lymphoblastic leukaemia

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Abstract

The tumour suppressor gene PTEN is commonly altered in T-cell acute lymphoblastic leukaemia but its prognostic impact is still debated. We screened a cohort of 573 fully characterised adult and paediatric T-cell acute lymphoblastic leukaemia (TALL) patients for genomic PTEN abnormalities. PTEN-inactivating mutations and/or deletions were identified in 91 cases (16%), including 18% of paediatric (49/277) and 14% of adult cases (42/296). Thirty-four patients harboured only mutations, 12 cases demonstrated only large deletions and 9 only microdeletions. About 36 patients had combined alterations. Different mechanisms of PTEN inactivation predicted differences in the clinical outcome for both adult and paediatric patients treated according to the GRAALL03/05 and FRALLE2000 protocols. Whereas large deletions predicted lower 5-year overall survival (P = 0.0053 in adults, P = 0.001 in children) and disease-free survival (P = 0.0009 in adults, P = 0.0002 in children), mutations were not associated with a worse prognosis. The prognostic impact of PTEN loss is therefore linked to the underlying type of genomic abnormality, both in adult and paediatric T-ALLs, demonstrating that detailed analysis of the type of abnormality type would be useful to refine risk stratification.
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Dates and versions

inserm-01819388 , version 1 (20-06-2018)

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M Tesio, A. Trinquand, P Ballerini, G Hypolite, L. Lhermitte, et al.. Age-related clinical and biological features of PTEN abnormalities in T-cell acute lymphoblastic leukaemia. Leukemia, 2017, 31 (12), pp.2594 - 2600. ⟨10.1038/leu.2017.157⟩. ⟨inserm-01819388⟩
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