, The New WHO Classification of Brain Tumours, Brain Pathology, vol.8, issue.3, pp.255-268, 1993.
DOI : 10.1007/978-94-009-3347-7_12
, Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma, New England Journal of Medicine, vol.352, issue.10, pp.987-996, 2005.
DOI : 10.1056/NEJMoa043330
, Radiation response of cell organelles, Micron, vol.31, issue.2, pp.165-181, 2000.
DOI : 10.1016/S0968-4328(99)00083-9
, Water radiolysis: influence of oxide surfaces on H 2 production under ionizing radiation, pp.235-253, 2011.
, Initial Events in the Cellular Effects of Ionizing Radiations: Clustered Damage in DNA, International Journal of Radiation Biology, vol.115, issue.1, pp.7-17, 1994.
DOI : 10.2307/3577289
, A Role for Homologous Recombination and Abnormal Cell-Cycle Progression in Radioresistance of Glioma-Initiating Cells, Molecular Cancer Therapeutics, vol.11, issue.9, pp.1863-1872, 2012.
DOI : 10.1158/1535-7163.MCT-11-1044
, Glioma stem cells promote radioresistance by preferential activation of the DNA damage response, Nature, vol.8, issue.7120, pp.756-760, 2006.
DOI : 10.1038/nn1473
, Targeting Cancer Stem Cells through L1CAM Suppresses Glioma Growth, Cancer Research, vol.68, issue.15, pp.6043-6048, 2008.
DOI : 10.1158/0008-5472.CAN-08-1079
, A review of 3 current radiosurgery systems, Surgical Neurology, vol.66, issue.6, pp.559-564, 2006.
DOI : 10.1016/j.surneu.2006.08.002
, Particle beam radiotherapy for head and neck tumors: Radiobiological basis and clinical experience, Head & Neck, vol.30, issue.8, pp.750-760, 2006.
DOI : 10.1016/0360-3016(94)90744-7
, Tumor eradication in rat glioma and bypass of immunosuppressive barriers using internal radiation with 188, 2011.
URL : https://hal.archives-ouvertes.fr/inserm-00638699
, Re-lipid nanocapsules, Biomaterials, vol.32, pp.6781-6790
, Iodine-125 brachytherapy for brain tumours - a review, Radiation Oncology, vol.7, issue.1, p.30, 2012.
DOI : 10.1186/1748-717X-7-30
, DGKI methylation status modulates the prognostic value of MGMT in glioblastoma patients treated with combined radio-chemotherapy with temozolomide Predictive value of MGMT in glioblastoma: a multicenter study, PLoS ONE J. Clin. Oncol, vol.9, pp.26-22065, 2008.
, Methylation of O-6-methylguanine DNA methyltransferase and loss of heterozygosity on 19q and/or 17p are Feature Review Trends in Pharmacological Sciences, 2007.
, overlapping features of secondary glioblastomas with prolonged survival, Clin. Cancer Res, vol.13, pp.2606-2613
, Gene Silencing and Benefit from Temozolomide in Glioblastoma, New England Journal of Medicine, vol.352, issue.10, pp.997-1003, 2005.
DOI : 10.1056/NEJMoa043331
, MGMT promoter methylation in malignant gliomas: ready for personalized medicine?, Nature Reviews Neurology, vol.113, issue.1, pp.39-51, 2010.
DOI : 10.1093/jnen/60.8.808
, MGMT promoter methylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastoma, Neuro-Oncology, vol.83, issue.2, pp.116-121, 2010.
DOI : 10.1007/s11060-006-9320-0
, Transferrin Adsorption onto PLGA Nanoparticles Governs Their Interaction with Biological Systems from Blood Circulation to Brain Cancer Cells, Pharmaceutical Research, vol.63, issue.3, pp.1495-1505, 2011.
DOI : 10.1016/j.addr.2010.10.008
, Identification of a cancer stem cell in human brain tumors, Cancer Res, vol.63, pp.5821-5828, 2003.
, Identification of human brain tumour initiating cells, Nature, vol.64, issue.suppl. 1, pp.396-401, 2004.
DOI : 10.1158/0008-5472.CAN-04-1364
, Potential therapeutic implications of cancer stem cells in glioblastoma, Biochemical Pharmacology, vol.80, issue.5, pp.654-665, 2010.
DOI : 10.1016/j.bcp.2010.04.035
, Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines, Cancer Cell, vol.9, issue.5, pp.391-403, 2006.
DOI : 10.1016/j.ccr.2006.03.030
, Is tumor growth sustained by rare cancer stem cells or dominant clones? Cancer Res, pp.4018-4021, 2008.
, Notch Promotes Radioresistance of Glioma Stem Cells, Stem Cells, vol.28, pp.17-28, 2009.
DOI : 10.1002/stem.261
URL : http://europepmc.org/articles/pmc2825687?pdf=render
, Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats, British Journal of Cancer, vol.110, issue.5, pp.1179-1188, 2014.
DOI : 10.1152/physiolgenomics.00147.2007
, Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells, Proceedings of the National Academy of Sciences, vol.29, issue.8, pp.6829-6834, 2013.
DOI : 10.1128/MCB.01472-08
URL : http://www.pnas.org/content/110/17/6829.full.pdf
, The importance of the stem cell marker prominin-1/CD133 in the uptake of transferrin and in iron metabolism in human colon cancer Caco-2 cells Integrin alpha 6 regulates glioblastoma stem cells, PLoS ONE Cell Stem Cell, vol.6, issue.6, pp.421-432, 2010.
, High-Throughput Flow Cytometry Screening Reveals a Role for Junctional Adhesion Molecule A as a Cancer Stem Cell Maintenance Factor, Cell Reports, vol.6, issue.1, pp.117-129, 2014.
DOI : 10.1016/j.celrep.2013.11.043
URL : https://doi.org/10.1016/j.celrep.2013.11.043
, A distinct subset of glioma cell lines with stem cell-like properties reflects the transcriptional phenotype of glioblastomas and overexpresses CXCR4 as therapeutic target, Glia, vol.86, issue.4, pp.590-602, 2011.
DOI : 10.1038/labinvest.3700482
, IDENTIFICATION OF A2B5+CD133??? TUMOR-INITIATING CELLS IN ADULT HUMAN GLIOMAS, Neurosurgery, vol.94, issue.2, pp.505-514, 2008.
DOI : 10.1073/pnas.94.23.12425
, A2B5 Cells from Human Glioblastoma have Cancer Stem Cell Properties, Brain Pathology, vol.4, issue.1, pp.211-221, 2010.
DOI : 10.1111/j.1750-3639.2009.00269.x
URL : https://hal.archives-ouvertes.fr/hal-00507521
, Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1, Cancer Cell, vol.17, issue.1, pp.98-110, 2010.
DOI : 10.1016/j.ccr.2009.12.020
, Targeting the Mechanisms of Resistance to Chemotherapy and Radiotherapy with the Cancer Stem Cell Hypothesis, Journal of Oncology, vol.8, issue.6, 2011.
DOI : 10.1038/nature03128
, J. Oncol, p.941876, 2011.
, The evolving landscape of glioblastoma stem cells, Current Opinion in Neurology, vol.26, issue.6, pp.701-707, 2013.
DOI : 10.1097/WCO.0000000000000032
, Essential Role of Gli Proteins in Glioblastoma Multiforme, Current Protein & Peptide Science, vol.14, issue.2, pp.133-140, 2013.
DOI : 10.2174/1389203711314020005
, CXCL12 (SDF1 alpha)?CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies? Clin, Cancer Res, vol.17, pp.2074-2080, 2011.
, Randomized Phase II Study of Cilengitide, an Integrin-Targeting Arginine-Glycine-Aspartic Acid Peptide, in Recurrent Glioblastoma Multiforme, Journal of Clinical Oncology, vol.26, issue.34, pp.5610-5617, 2008.
DOI : 10.1200/JCO.2008.16.7510
, Safety and Efficacy of Bevacizumab With Hypofractionated Stereotactic Irradiation for Recurrent Malignant Gliomas, International Journal of Radiation Oncology*Biology*Physics, vol.75, issue.1, pp.156-163, 2009.
DOI : 10.1016/j.ijrobp.2008.10.043
, Convection-enhanced delivery of macromolecules in the brain., Proceedings of the National Academy of Sciences, vol.91, issue.6, pp.2076-2080, 1994.
DOI : 10.1073/pnas.91.6.2076
, Chimioth??rapie locale dans les gliomes malins??: de l???injection ?? la seringue aux nanotechnologies, Revue Neurologique, vol.164, issue.6-7, pp.547-553, 2008.
DOI : 10.1016/j.neurol.2008.03.015
, Guiding intracortical brain tumour cells to an extracortical cytotoxic hydrogel using aligned polymeric nanofibres, Nature Materials, vol.33, issue.3, pp.309-316, 2014.
DOI : 10.1016/j.biomaterials.2012.05.021
, Clinical experience with alpha-particleemitting At-211: Treatment of recurrent brain tumor patients with At-211-labeled chimeric antitenascin monoclonal antibody 81C6, 2008.
, J. Nucl. Med, vol.49, pp.30-38
, Understanding biophysicochemical interactions at the nano???bio interface, Nature Materials, vol.20, issue.7, pp.543-557, 2009.
DOI : 10.1289/ehp.6000
, Nanocarriers as an emerging platform for cancer therapy, Nature Nanotechnology, vol.8, issue.12, pp.751-760, 2007.
DOI : 10.1038/bjc.1996.587
, Genomics Identifies Medulloblastoma Subgroups That Are Enriched for Specific Genetic Alterations, Journal of Clinical Oncology, vol.24, issue.12, pp.1924-1931, 2006.
DOI : 10.1200/JCO.2005.04.4974
, Enhanced Self-Renewal Capability in Hepatic Stem/Progenitor Cells Drives Cancer Initiation, Gastroenterology, vol.133, issue.3, pp.937-950, 2007.
DOI : 10.1053/j.gastro.2007.06.016
, Wnt activation is implicated in glioblastoma radioresistance, Laboratory Investigation, vol.61, issue.3, pp.466-473, 2012.
DOI : 10.1016/j.radonc.2011.05.044
URL : https://www.nature.com/articles/labinvest2011161.pdf
, Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma, International Journal of Oncology, vol.43, issue.1, pp.219-227, 2013.
DOI : 10.3892/ijo.2013.1916
, Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3?? Inactivation, Science, vol.24, issue.8, pp.667-670, 2008.
DOI : 10.1038/sj.emboj.7600633
URL : http://europepmc.org/articles/pmc2597039?pdf=render
, Protein phosphatase 2C alpha dephosphorylates axin and activates LEF-1-dependent transcription, 2000.
DOI : 10.1074/jbc.275.4.2399
URL : http://www.jbc.org/content/275/4/2399.full.pdf
, J. Biol. Chem, vol.275, pp.2399-2403
, Protein phosphatase 1 regulates assembly and function of the ??-catenin degradation complex, The EMBO Journal, vol.438, issue.6, p.1511, 2007.
DOI : 10.1038/sj.emboj.7601607
, Tankyrase, a Poly(ADP-Ribose) Polymerase at Human Telomeres, Science, vol.282, issue.5393, pp.1484-1487, 1998.
DOI : 10.1126/science.282.5393.1484
, Tankyrase function at telomeres, spindle poles, and beyond, Biochimie, vol.90, issue.1, pp.83-92, 2008.
DOI : 10.1016/j.biochi.2007.07.012
, Small molecule???mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer, Nature Chemical Biology, vol.222, issue.2, pp.100-107, 2009.
DOI : 10.1038/nchembio.137
, Novel Synthetic Antagonists of Canonical Wnt Signaling Inhibit Colorectal Cancer Cell Growth, Cancer Research, vol.71, issue.1, p.197, 2011.
DOI : 10.1158/0008-5472.CAN-10-1282
, A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice, Cancer Research, vol.72, issue.11, pp.2822-2832, 2012.
DOI : 10.1158/0008-5472.CAN-11-3336
URL : http://cancerres.aacrjournals.org/content/72/11/2822.full.pdf
, Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling, Nature, vol.7, issue.7264, pp.614-620, 2009.
DOI : 10.1074/mcp.M800029-MCP200
, Structural Basis for the Interaction between Tankyrase-2 and a Potent Wnt-Signaling Inhibitor, Journal of Medicinal Chemistry, vol.53, issue.14, pp.5352-5355, 2010.
DOI : 10.1021/jm100249w
, Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors, Nature Biotechnology, vol.185, issue.3, pp.283-288, 2012.
DOI : 10.1038/nbt0308-303
, The Anti-Helminthic Niclosamide Inhibits Wnt/Frizzled1 Signaling, Biochemistry, vol.48, issue.43, pp.10267-10274, 2009.
DOI : 10.1021/bi9009677
URL : http://europepmc.org/articles/pmc2801776?pdf=render
, Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/ beta-catenin pathway Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells, PLoS ONE Chin. J. Cancer, vol.6, issue.31, pp.178-184, 2011.
, Antihelminth Compound Niclosamide Downregulates Wnt Signaling and Elicits Antitumor Responses in Tumors with Activating APC Mutations, Cancer Research, vol.71, issue.12, pp.4172-4182, 2011.
DOI : 10.1158/0008-5472.CAN-10-3978
, Dkk1 stabilizes Wnt co-receptor LRP6: implication for Wnt ligand-induced LRP6 down-regulation Tyrosine kinase inhibitor STI-571/Gleevec downregulates the beta-catenin signaling activity, PLoS ONE Cancer Lett, vol.5, issue.193, p.161, 2003.
, Mechanisms of action of rapamycin in gliomas, Neuro-Oncology, vol.7, issue.1, pp.1-11, 2005.
DOI : 10.1038/sj.onc.1206197
, Mechanisms of Disease: the PI3K???Akt???PTEN signaling node???an intercept point for the control of angiogenesis in brain tumors, Nature Clinical Practice Neurology, vol.401, issue.12, pp.682-693, 2007.
DOI : 10.1038/ncpneuro0661
, Feature Review Trends in Pharmacological Sciences, vol.36, issue.4, 2015.
, PI3K/PTEN signaling in angiogenesis and tumorigenesis Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas, Advances in Cancer Research, pp.19-65, 2005.
, Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma, Cancer Res, vol.61, pp.6674-6678, 2001.
, Role of Akt in human malignant glioma: from oncogenesis to tumor aggressiveness, Journal of Neuro-Oncology, vol.8, issue.2, p.205, 2014.
DOI : 10.1016/j.ccr.2005.11.006
, Rapamycin-mediated mTOR inhibition attenuates survivin and sensitizes glioblastoma cells to radiation therapy, Acta Biochimica et Biophysica Sinica, vol.67, issue.2, pp.292-300, 2011.
DOI : 10.1158/0008-5472.CAN-06-3497
, Enhanced radiation damage of tumor vasculature by mTOR inhibitors, Oncogene, vol.24, issue.35, pp.5414-5422, 2005.
DOI : 10.1002/(SICI)1097-4652(199902)178:2<235::AID-JCP13>3.0.CO;2-S
, Inhibition of the mammalian target of rapamycin sensitizes U87 Xenografts to fractionated radiation therapy, Cancer Res, vol.62, pp.7291-7297, 2002.
, Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins, Proceedings of the National Academy of Sciences, vol.4, issue.11, p.14866, 1999.
DOI : 10.1038/3282
, Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor, Nature Medicine, vol.11, issue.2, pp.128-135, 2002.
DOI : 10.1006/cyto.1998.0426
, Bevacizumab plus Radiotherapy???Temozolomide for Newly Diagnosed Glioblastoma, New England Journal of Medicine, vol.370, issue.8, pp.709-722, 2014.
DOI : 10.1056/NEJMoa1308345
, PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo, Genes & Development, vol.22, issue.4, pp.436-448, 2008.
DOI : 10.1101/gad.1627008
, mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt, Cancer Research, vol.66, issue.3, pp.1500-1508, 2006.
DOI : 10.1158/0008-5472.CAN-05-2925
, Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex, Science, vol.307, issue.5712, pp.1098-1101, 2005.
DOI : 10.1126/science.1106148
, Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance, Proceedings of the National Academy of Sciences, vol.408, issue.6815, pp.14056-14061, 2007.
DOI : 10.1038/35050135
, IGF1 Receptor Signaling Regulates Adaptive Radioprotection in Glioma Stem Cells, STEM CELLS, vol.17, issue.4, pp.627-640, 2013.
DOI : 10.1158/1078-0432.CCR-10-2621
, Phase I/II Trial of Erlotinib and Temozolomide With Radiation Therapy in the Treatment of Newly Diagnosed Glioblastoma Multiforme: North Central Cancer Treatment Group Study N0177, Journal of Clinical Oncology, vol.26, issue.34, pp.5603-5609, 2008.
DOI : 10.1200/JCO.2008.18.0612
, Phase II Study of Erlotinib Plus Temozolomide During and After Radiation Therapy in Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma, Journal of Clinical Oncology, vol.27, issue.4, pp.579-584, 2009.
DOI : 10.1200/JCO.2008.18.9639
, Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiforme, Journal of Neuro-Oncology, vol.26, issue.9, pp.93-99, 2010.
DOI : 10.1016/j.ijrobp.2006.01.018
, Influence of EGFR-amplification, EGFR-, EGFRvIII-and PTEN-expression as well as MGMT-promotor methylation status on outcome in patients with primary glioblastoma treated with radiation, temozolomide and EGFRinhibition with Cetuximab: interim analysis from the GERTprotocol, Strahlenther. Und Onkol, vol.185, p.16, 2009.
, Phase II study of concurrent radiation therapy, temozolomide, and bevacizumab followed by bevacizumab/ everolimus as first-line treatment for patients with glioblastoma, Clin. Adv. Hematol. Oncol, vol.10, pp.240-246, 2012.
, Phase 2 trial of erlotinib plus sirolimus in adults with recurrent glioblastoma, Journal of Neuro-Oncology, vol.65, issue.2, pp.219-230, 2010.
DOI : 10.1016/j.ijrobp.2006.01.018
, A pilot study of everolimus and gefitinib in the treatment of recurrent glioblastoma (GBM), Journal of Neuro-Oncology, vol.66, issue.1, pp.99-105, 2009.
DOI : 10.1007/s11060-008-9741-z
, Synthesis and biological evaluation of pyrido[3???,2???:4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110?? inhibitors, Bioorganic & Medicinal Chemistry Letters, vol.17, issue.9, pp.2438-2442, 2007.
DOI : 10.1016/j.bmcl.2007.02.032
, Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity, Molecular Cancer Therapeutics, vol.7, issue.7, pp.1851-1863, 2008.
DOI : 10.1158/1535-7163.MCT-08-0017
, Akt and autophagy cooperate to promote survival of drug-resistant glioma The dual PI3K/mTOR inhibitor NVP- BEZ235 is a potent inhibitor of ATM-and DNA-PKCs-mediated DNA damage responses, Sci. Signal. Neoplasia, vol.3, issue.14, pp.34-43, 2010.
, Inhibition of Autophagy as a Strategy to Augment Radiosensitization by the Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235, Molecular Pharmacology, vol.82, issue.6, 2012.
DOI : 10.1124/mol.112.080408
, Mol. Pharmacol, vol.82, pp.1230-1240
, Preclinical Evaluation of Radiation and Perifosine in a Genetically and Histologically Accurate Model of Brainstem Glioma, Cancer Research, vol.70, issue.6, pp.2548-2557, 2010.
DOI : 10.1158/0008-5472.CAN-09-2503
, Akt signaling pathway: a target for radiosensitizing human malignant glioma, Neuro Oncol, vol.12, pp.434-443, 2010.
URL : https://hal.archives-ouvertes.fr/hal-01636179
, Expression of Notch-1 and Its Ligands, Delta-Like-1 and Jagged-1, Is Critical for Glioma Cell Survival and Proliferation, Cancer Research, vol.65, issue.6, pp.2353-2363, 2005.
DOI : 10.1158/0008-5472.CAN-04-1890
, Notch Pathway Inhibition Depletes Stem-like Cells and Blocks Engraftment in Embryonal Brain Tumors, Cancer Research, vol.66, issue.15, pp.7445-7452, 2006.
DOI : 10.1158/0008-5472.CAN-06-0858
, Notch Promotes Radioresistance of Glioma Stem Cells, Stem Cells, vol.28, pp.17-28, 2010.
DOI : 10.1002/stem.261
, ??-Secretase Inhibitor-I Enhances Radiosensitivity of Glioblastoma Cell Lines by Depleting CD133+ Tumor Cells, Archives of Medical Research, vol.41, issue.7, pp.519-529, 2010.
DOI : 10.1016/j.arcmed.2010.10.006
, A hierarchical cascade activated by non-canonical Notch signaling and the mTOR???Rictor complex regulates neglect-induced death in mammalian cells, Cell Death & Differentiation, vol.91, issue.6, pp.879-889, 2009.
DOI : 10.4049/jimmunol.177.8.5041
, Arsenic trioxide depletes cancer stem-like cells and inhibits repopulation of neurosphere derived from glioblastoma by downregulation of Notch pathway, Toxicology Letters, vol.220, issue.1, pp.61-69, 2013.
DOI : 10.1016/j.toxlet.2013.03.019
, HEDGEHOG-GLI1 Signaling Regulates Human Glioma Growth, Cancer Stem Cell Self-Renewal, and Tumorigenicity, Current Biology, vol.17, issue.2, pp.165-172, 2007.
DOI : 10.1016/j.cub.2006.11.033
, Essential role of the Hedgehog signaling pathway in human glioma-initiating cells, Cancer Science, vol.8, issue.7, p.1306, 2011.
DOI : 10.1186/1471-2407-8-29
, Cyclopamine-Mediated Hedgehog Pathway Inhibition Depletes Stem-Like Cancer Cells in Glioblastoma, Stem Cells, vol.66, issue.10, pp.2524-2533, 2007.
DOI : 10.1016/j.urolonc.2005.11.038
, TGF-β2 Signaling in High-Grade Gliomas, Current Pharmaceutical Biotechnology, vol.12, issue.12, pp.2150-2157, 2011.
DOI : 10.2174/138920111798808347
, Effect of irradiation on transforming growth factor-beta secretion by malignant glioma cells, Journal of Neuro-Oncology, vol.33, issue.3, pp.195-200, 1997.
DOI : 10.1023/A:1005791621265
, Cellular Sources of Transforming Growth Factor-?? Isoforms in Early and Chronic Radiation Enteropathy, The American Journal of Pathology, vol.153, issue.5, pp.1531-1540, 1998.
DOI : 10.1016/S0002-9440(10)65741-0
, Therapeutic Targets in Malignant Glioblastoma Microenvironment, Seminars in Radiation Oncology, vol.19, issue.3, pp.163-170, 2009.
DOI : 10.1016/j.semradonc.2009.02.004
, Isoform-Specific Activation of Latent Transforming Growth Factor ?? (LTGF-??) by Reactive Oxygen Species, Radiation Research, vol.166, issue.6, pp.839-848, 2006.
DOI : 10.1667/RR0695.1
, Role of TGF-??1 and nitric oxide in the bystander response of irradiated glioma cells, Oncogene, vol.59, issue.4, pp.434-440, 2008.
DOI : 10.1073/pnas.030420797
, Blockade of TGF-?? Signaling by the TGF??R-I Kinase Inhibitor LY2109761 Enhances Radiation Response and Prolongs Survival in Glioblastoma, Cancer Research, vol.71, issue.23, pp.7155-7167, 2011.
DOI : 10.1158/0008-5472.CAN-11-1212
, Trimodal Glioblastoma Treatment Consisting of Concurrent Radiotherapy, Temozolomide, and the Novel TGF-?? Receptor I Kinase Inhibitor LY2109761, Neoplasia, vol.13, issue.6, pp.537-549, 2011.
DOI : 10.1593/neo.11258
, Resistance of Glioblastoma-Initiating Cells to Radiation Mediated by the Tumor Microenvironment Can Be Abolished by Inhibiting Transforming Growth Factor-??, Cancer Research, vol.72, issue.16, pp.4119-4129, 2012.
DOI : 10.1158/0008-5472.CAN-12-0546
, 2 with AP 12009 in Recurrent Malignant Gliomas: From Preclinical to Phase I/II Studies, Oligonucleotides, vol.17, issue.2, pp.201-212, 2007.
DOI : 10.1089/oli.2006.0053
, Feature Review Trends in Pharmacological Sciences, vol.36, issue.4, 2015.
, Targeted therapy for high-grade glioma with the TGF-??2 inhibitor trabedersen: results of a randomized and controlled phase IIb study, Neuro-Oncology, vol.26, issue.13, pp.132-142, 2011.
DOI : 10.1200/JCO.2007.14.8163
, STAT3 Regulation of Glioblastoma Pathogenesis, Current Molecular Medicine, vol.9, issue.5, pp.580-590, 2009.
DOI : 10.2174/156652409788488739
, Inhibition of phosphorylated STAT3 by cucurbitacin I enhances chemoradiosensitivity in medulloblastoma-derived cancer stem cells, Child's Nervous System, vol.7, issue.3, pp.363-373, 2012.
DOI : 10.1186/1471-2407-7-149
, Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis, Journal of Cellular Physiology, vol.217, issue.3, pp.976-993, 2012.
DOI : 10.1002/jcp.21541
, 142: From Bench to bedside: experience of the glioblastoma model for optimization of radiosensitization, Radiotherapy and Oncology, vol.110, pp.25-28, 2012.
DOI : 10.1016/S0167-8140(15)34163-3
, Radioresistance induced by the high molecular forms of the basic fibroblast growth factor is associated with an increased G2 delay and a hyperphosphorylation of p34CDC2 in HeLa cells, Cancer Res, vol.57, pp.1364-1370, 1997.
, The radioprotective effect of the 24???kDa FGF-2 isoform in HeLa cells is related to an increased expression and activity of the DNA dependent protein kinase (DNA-PK) catalytic subunit, Oncogene, vol.21, issue.42, pp.6471-6479, 2002.
DOI : 10.1016/S0092-8674(00)80111-7
, RhoB controls the 24???kDa FGF-2-induced radioresistance in HeLa cells by preventing post-mitotic cell death, Oncogene, vol.21, issue.39, pp.5998-6006, 2002.
DOI : 10.1038/nbt1094-1003
URL : http://www.nature.com/onc/journal/v21/n39/pdf/1205746a.pdf
, Radiation-induced Epidermal Growth Factor Receptor Nuclear Import Is Linked to Activation of DNA-dependent Protein Kinase, Journal of Biological Chemistry, vol.6, issue.35, pp.31182-31189, 2005.
DOI : 10.1093/emboj/18.5.1397
URL : http://www.jbc.org/content/280/35/31182.full.pdf
, Activation of RhoB by Hypoxia Controls Hypoxia-Inducible Factor-1?? Stabilization through Glycogen Synthase Kinase-3 in U87 Glioblastoma Cells, Cancer Research, vol.66, issue.1, pp.482-489, 2006.
DOI : 10.1158/0008-5472.CAN-05-2299
URL : http://cancerres.aacrjournals.org/content/canres/66/1/482.full.pdf
, Farnesylated RhoB inhibits radiation-induced mitotic cell death and controls radiation-induced centrosome overduplication, Cell Death and Differentiation, vol.4, issue.5, pp.492-501, 2005.
DOI : 10.4161/cc.1.6.272
URL : http://www.nature.com/cdd/journal/v12/n5/pdf/4401586a.pdf
, Farnesyltransferase inhibitor, R115777, reverses the resistance of human glioma cell lines to ionizing radiation, International Journal of Cancer, vol.19, issue.1, pp.43-48, 2002.
DOI : 10.1007/BF01053280
URL : http://onlinelibrary.wiley.com/doi/10.1002/ijc.10439/pdf
, The farnesyltransferase inhibitor R115777 reduces hypoxia and matrix metalloproteinase 2 expression in human glioma xenograft, Clin. Cancer Res, vol.9, pp.6062-6068, 2003.
, Inhibition of Rho pathways induces radiosensitization and oxygenation in human glioblastoma xenografts, Oncogene, vol.22, issue.55, pp.8861-8869, 2003.
DOI : 10.1074/jbc.M010190200
URL : http://www.nature.com/onc/journal/v22/n55/pdf/1207095a.pdf
, Protein-kinase-C mediates basic fibroblast growth-factor protection of endothelial-cells against radiation-induced apoptosis, Cancer Res, vol.54, pp.2591-2597, 1994.
, Sublethal irradiation promotes migration and invasiveness of glioma cells: Implications for radiotherapy of human glioblastoma, Cancer Res, vol.61, pp.2744-2750, 2001.
, ??v??3 and ??v??5 integrins control glioma cell response to ionising radiation through ILK and RhoB, International Journal of Cancer, vol.12, issue.150, pp.357-364, 2008.
DOI : 10.1038/sj.cdd.4401586
URL : http://onlinelibrary.wiley.com/doi/10.1002/ijc.23498/pdf
, Phase I Trial of Tipifarnib (R115777) Concurrent With Radiotherapy in Patients with Glioblastoma Multiforme, International Journal of Radiation Oncology*Biology*Physics, vol.68, issue.5, pp.1396-1401, 2007.
DOI : 10.1016/j.ijrobp.2007.02.043
, ??v??3 Integrin and Fibroblast growth factor receptor 1 (FGFR1): Prognostic factors in a phase I???II clinical trial associating continuous administration of Tipifarnib with radiotherapy for patients with newly diagnosed glioblastoma, European Journal of Cancer, vol.49, issue.9, pp.2161-2169, 2013.
DOI : 10.1016/j.ejca.2013.02.033
, Phase I/IIa Study of Cilengitide and Temozolomide With Concomitant Radiotherapy Followed by Cilengitide and Temozolomide Maintenance Therapy in Patients With Newly Diagnosed Glioblastoma, Journal of Clinical Oncology, vol.28, issue.16, pp.2712-2718, 2010.
DOI : 10.1200/JCO.2009.26.6650
, Preclinical evidence that SSR128129E ??? A novel small-molecule multi-fibroblast growth factor receptor blocker ??? Radiosensitises human glioblastoma, European Journal of Cancer, vol.50, issue.13, pp.2351-2359, 2014.
DOI : 10.1016/j.ejca.2014.05.012
, Hypoxia ??? a key regulatory factor in tumour growth, Nature Reviews Cancer, vol.18, issue.1, pp.38-47, 2002.
DOI : 10.1128/MCB.18.5.2845
, Hypoxia-Inducible Factors, Stem Cells, and Cancer, Cell, vol.129, issue.3, pp.465-472, 2007.
DOI : 10.1016/j.cell.2007.04.019
URL : https://doi.org/10.1016/j.cell.2007.04.019
, Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells, Cancer Cell, vol.15, issue.6, pp.501-513, 2009.
DOI : 10.1016/j.ccr.2009.03.018
URL : https://doi.org/10.1016/j.ccr.2009.03.018
, Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1, Radiotherapy and Oncology, vol.75, issue.1, pp.89-98, 2005.
DOI : 10.1016/j.radonc.2005.01.009
, PML inhibits HIF-1?? translation and neoangiogenesis through repression of mTOR, Nature, vol.9, issue.7104, pp.779-785, 2006.
DOI : 10.1038/nature03915
, Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy., Proceedings of the National Academy of Sciences, vol.88, issue.24, pp.11460-11464, 1991.
DOI : 10.1073/pnas.88.24.11460
URL : http://www.pnas.org/content/88/24/11460.full.pdf
, Doxorubicin in sterically stabilized liposomes, Nature, vol.380, issue.6574, pp.561-562, 1996.
DOI : 10.1038/380561a0
, Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology, Advanced Drug Delivery Reviews, vol.66, 2014.
DOI : 10.1016/j.addr.2013.11.009
, Adv. Drug Deliv. Rev, vol.66, pp.2-25
, Delivering nanomedicine to solid tumors, Nature Reviews Clinical Oncology, vol.3, issue.11, pp.653-664, 2010.
DOI : 10.1016/j.nano.2008.07.007
, Radiation dose enhancement in tumors with iodine, Medical Physics, vol.10, issue.1, pp.75-78, 1983.
DOI : 10.1118/1.595378
, X-ray phototherapy for canine brain masses, Radiation Oncology Investigations, vol.22, issue.1, pp.8-14, 1997.
DOI : 10.1016/0360-3016(94)90649-1
, First radiotherapy of human metastatic brain tumors delivered by a computerized tomography scanner (CTRx) Int, 1999.
, J. Radiat. Oncol. Biol. Phys, vol.45, pp.1127-1132
, Intracerebral delivery of 5-iodo-2???-deoxyuridine in??combination with synchrotron stereotactic radiation for the therapy of the F98 glioma, Journal of Synchrotron Radiation, vol.16, issue.4, pp.573-581, 2009.
DOI : 10.1107/S0909049509016987
URL : https://hal.archives-ouvertes.fr/inserm-00410444
, the brain, Journal of Microencapsulation, vol.32, issue.6, pp.789-801, 1998.
DOI : 10.1023/A:1005704913330
URL : https://hal.archives-ouvertes.fr/hal-00935640
, Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer, Transl. Cancer Res, vol.2, pp.330-342, 2013.
, Radiosensitization of DNA by Gold Nanoparticles Irradiated with High-Energy Electrons, Radiation Research, vol.169, issue.1, pp.19-27, 2008.
DOI : 10.1667/RR1080.1
, Selective targeting of brain tumors with gold nanoparticle-induced radiosensitization Photoactivation of gold nanoparticles for glioma treatment, PLoS ONE Nanomed. Nanotechnol. Biol. Med, vol.8, issue.9, pp.1089-1097, 2013.
, <I>In Vitro</I> Radiosensitizing Effects of Ultrasmall Gadolinium Based Particles on Tumour Cells, Journal of Nanoscience and Nanotechnology, vol.11, issue.9, pp.7833-7839, 2011.
DOI : 10.1166/jnn.2011.4725
, The effect of particle design on cellular internalization pathways, Proceedings of the National Academy of Sciences, vol.40, issue.4, p.11613, 2008.
DOI : 10.1002/1097-0320(20000801)40:4<280::AID-CYTO4>3.0.CO;2-7
, Effect of Reaction Parameters on Composition and Morphology of Titanate Nanomaterials, The Journal of Physical Chemistry C, vol.113, issue.29, pp.12682-12689, 2009.
DOI : 10.1021/jp903195h
URL : https://hal.archives-ouvertes.fr/hal-00404290
, The radiosensitization effect of titanate nanotubes as a new tool in radiation therapy for glioblastoma: A proof-of-concept, Radiotherapy and Oncology, vol.108, issue.1, pp.136-142, 2013.
DOI : 10.1016/j.radonc.2013.04.004
, Oxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cells, Toxicology Letters, vol.180, issue.3, pp.222-229, 2008.
DOI : 10.1016/j.toxlet.2008.06.869
, Titanium dioxide nanoparticles induced cytotoxicity, oxidative stress and DNA damage in human amnion epithelial (WISH) cells, Toxicology in Vitro, vol.26, issue.2, pp.351-361, 2012.
DOI : 10.1016/j.tiv.2011.12.011
, Oxidative stress-mediated cytotoxicity and apoptosis induction by TiO2 nanofibers in HeLa cells, European Journal of Pharmaceutics and Biopharmaceutics, vol.81, issue.2, pp.324-333, 2012.
DOI : 10.1016/j.ejpb.2012.02.013
URL : http://orbit.dtu.dk/en/publications/oxidative-stressmediated-cytotoxicity-and-apoptosis-induction-by-tio2-nanofibers-in-hela-cells(2ced100f-496b-4aeb-898b-7eaa9511a3ee).html
, The Effects of G2-Phase Enrichment and Checkpoint Abrogation on Low-Dose Hyper-Radiosensitivity, International Journal of Radiation Oncology*Biology*Physics, vol.77, issue.5, pp.1509-1517, 2010.
DOI : 10.1016/j.ijrobp.2010.01.028
URL : http://europepmc.org/articles/pmc3818906?pdf=render
, Concomitant treatment of F98 glioma cells with new liposomal platinum compounds and ionizing radiation, Journal of Neuro-Oncology, vol.53, issue.2, 2010.
DOI : 10.1017/S0317167100006715
URL : http://europepmc.org/articles/pmc3226798?pdf=render
, J. Neuro Oncol, vol.97, pp.187-193
, Efficacy of Cisplatin-loaded polybutyl cyanoacrylate nanoparticles on the glioblastoma, Tumor Biology, vol.28, issue.5, pp.4799-4806, 2014.
DOI : 10.1200/JCO.2009.22.4725
, Comparison of doxorubicin and its nonpegylated liposomal form as radiosensitizer in high grade glioma xenografts, J. Clin. Oncol, vol.23, p.1524, 2005.
, RNOP-09: Pegylated liposomal doxorubicine and prolonged temozolomide in addition to radiotherapy in newly diagnosed glioblastoma - a phase II study, BMC Cancer, vol.17, issue.Suppl 4, p.308, 2009.
DOI : 10.1517/13543784.17.8.1225
, On the mechanism of action of doxorubicin encapsulation in nanospheres for the reversal of multidrug resistance, Cancer Chemotherapy and Pharmacology, vol.37, issue.6, pp.556-560, 1996.
DOI : 10.1007/s002800050428
, -lactide-co-glycolide) nanospheres to glioblastoma cells, Journal of Microencapsulation, vol.55, issue.1, pp.29-36, 2011.
DOI : 10.1016/j.brainres.2009.01.011
, Distribution of daunorubicin and daunorubicinol in human glioma tumors after administration of liposomal daunorubicin, Cancer Chemotherapy and Pharmacology, vol.44, issue.2, pp.173-176, 1999.
DOI : 10.1007/s002800050964
, A new generation of anticancer, drug-loaded, colloidal vectors reverses multidrug resistance in glioma and reduces tumor progression in rats, Molecular Cancer Therapeutics, vol.5, issue.7, pp.1710-1722, 2006.
DOI : 10.1158/1535-7163.MCT-06-0289
URL : https://hal.archives-ouvertes.fr/hal-00129865
, In vivo evaluation of intracellular drug-nanocarriers infused into intracranial tumours by convection-enhanced delivery: distribution and radiosensitisation efficacy, Journal of Neuro-Oncology, vol.28, issue.2, pp.195-205, 2010.
DOI : 10.1016/S0360-3016(01)01597-8
, Radiosensitization of paclitaxel, etanidazole and paclitaxel+etanidazole nanoparticles on hypoxic human tumor cells in vitro, Biomaterials, vol.28, issue.25, pp.3724-3730, 2007.
DOI : 10.1016/j.biomaterials.2007.04.032
, Radiosensitization of malignant gliomas following intracranial delivery of paclitaxel biodegradable polymer microspheres, Journal of Neurosurgery, vol.5, issue.5, pp.1078-1085, 2014.
DOI : 10.1002/smll.201000028
, The influence of the penetrating peptide iRGD on the effect of paclitaxel-loaded MT1-AF7p-conjugated nanoparticles on glioma cells, Biomaterials, vol.34, issue.21, pp.5138-5148, 2013.
DOI : 10.1016/j.biomaterials.2013.03.036
, PEGylated poly(trimethylene carbonate) nanoparticles loaded with paclitaxel for the treatment of advanced glioma: In vitro and in vivo evaluation, International Journal of Pharmaceutics, vol.420, issue.2, pp.385-394, 2011.
DOI : 10.1016/j.ijpharm.2011.08.052
, Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas, The Lancet, vol.345, issue.8956, pp.1008-1012, 1995.
DOI : 10.1016/S0140-6736(95)90755-6
, A phase 3 trial of local chemotherapy with biodegradable carmustine
(BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma, Neuro-Oncology, vol.5, issue.2, pp.79-88, 2003.
DOI : 10.1159/000061237
, Local and sustained delivery of 5-fluorouracil from biodegradable microspheres for the radiosensitization of glioblastoma, Cancer, vol.7, issue.2, pp.325-330, 1999.
DOI : 10.1093/oxfordjournals.annonc.a010610
, Stereotaxic implantation of 5-fluorouracil-releasing microspheres in malignant glioma, Cancer, vol.52, issue.2, pp.405-410, 2004.
DOI : 10.1227/01.NEU.0000053211.39087.D1
, Local and Sustained Delivery of 5-Fluorouracil from Biodegradable Microspheres for the Radiosensitization of Malignant Glioma: A Randomized Phase II Trial, Neurosurgery, vol.5, issue.Suppl 6, pp.242-247, 2005.
DOI : 10.1093/neuonc/5.2.79
, Targeting by cmHsp70.1-antibody coated and survivin miRNA plasmid loaded nanoparticles to radiosensitize glioblastoma cells, Journal of Controlled Release, vol.172, issue.1, pp.201-206, 2013.
DOI : 10.1016/j.jconrel.2013.08.020
, Inhibition of the EGFR with nanoparticles encapsulating antisense oligonucleotides of the EGFR enhances radiosensitivity in SCCVII cells, Medical Oncology, vol.12, issue.7, pp.715-721, 2010.
DOI : 10.1016/S0167-4889(96)00068-7
, Silencing of miR-21 by locked nucleic acid???lipid nanocapsule complexes sensitize human glioblastoma cells to radiation-induced cell death, International Journal of Pharmaceutics, vol.454, issue.2, pp.765-774, 2013.
DOI : 10.1016/j.ijpharm.2013.05.049
, Specialization of tumour vasculature, Nature Reviews Cancer, vol.407, issue.2, pp.83-90, 2002.
DOI : 10.1038/35025220
, Arg-Gly-Asp: A versatile cell recognition signal, Cell, vol.44, issue.4, pp.517-518, 1986.
DOI : 10.1016/0092-8674(86)90259-X
, In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice, Nature Nanotechnology, vol.47, issue.1, pp.47-52, 2007.
DOI : 10.1007/BF00046364
, Specific Targeting of Tumor Angiogenesis by RGD-Conjugated Ultrasmall Superparamagnetic Iron Oxide Particles Using a Clinical 1.5-T Magnetic Resonance Scanner, Cancer Research, vol.67, issue.4, pp.1555-1562, 2007.
DOI : 10.1158/0008-5472.CAN-06-1668
, In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags, Nature Biotechnology, vol.100, issue.1, pp.83-90, 2008.
DOI : 10.1073/pnas.2232479100
, Biomimetic, synthetic HDL nanostructures for lymphoma, Proceedings of the National Academy of Sciences, vol.468, issue.9, pp.2511-2516, 2013.
DOI : 10.1007/978-1-59745-249-6_5
, Antibody-functionalized polymer-coated gold nanoparticles targeting cancer cells: an in vitro and in vivo study, Journal of Materials Chemistry, vol.12, issue.39, pp.21305-21312, 2012.
DOI : 10.1634/theoncologist.12-12-1379
, Zr-labeled anti-endoglin antibody-targeted gold nanoparticles for imaging cancer: implications for future cancer therapy, Nanomedicine, vol.29, issue.13, pp.1923-1937, 2014.
DOI : 10.1002/ijc.2910540303
, Zr-labeled cetuximab in mice, Contrast Media & Molecular Imaging, vol.34, issue.suppl 1, pp.402-408, 2013.
DOI : 10.1007/s00259-006-0271-7
, Local endostatin treatment of gliomas administered by microencapsulated producer cells, Nature Biotechnology, vol.97, issue.1, pp.29-34, 2001.
DOI : 10.1007/s004010050979
, Curcumin-loaded lipid nanocarrier for improving biovaibility, stability and cytotoxicity against malignant glioma cells. Drug Deliv, 2014.
, Dendrosomal curcumin nanoformulation downregulates pluripotency genes via miR-145 activation in U87MG glioblastoma cells, Int. J. Nanomed, vol.9, pp.403-417, 2014.
, Enhanced accumulation of curcumin and temozolomide loaded magnetic nanoparticles executes profound cytotoxic effect in glioblastoma spheroid model, European Journal of Pharmaceutics and Biopharmaceutics, vol.85, issue.3, pp.452-462, 2013.
DOI : 10.1016/j.ejpb.2013.07.013
, A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors, Cancer Biology & Therapy, vol.62, issue.5, pp.464-473, 2011.
DOI : 10.1158/0008-5472.CAN-04-1364
, Enhanced stability and activity of temozolomide in primary glioblastoma multiforme cells with cucurbit[n]uril, Chemical Communications, vol.33, issue.79, pp.9843-9845, 2012.
DOI : 10.1016/j.biomaterials.2012.02.030
, Effects of NF??B decoy oligonucleotides released from biodegradable polymer microparticles on a glioblastoma cell line, Biomaterials, vol.23, issue.13, pp.2773-2781, 2002.
DOI : 10.1016/S0142-9612(02)00013-3
, Schedule-Dependent Pulsed Paclitaxel Radiosensitization for Thoracic Malignancy, American Journal of Clinical Oncology, vol.24, issue.5, pp.432-437, 2001.
DOI : 10.1097/00000421-200110000-00004
, The optimal schedule for 5-fluorouracil radiosensitization in colon cancer cell lines, Oncology Reports, vol.16, p.1085, 2006.
DOI : 10.3892/or.16.5.1085
, Radionuclide carriers for targeting of cancer, International Journal of Nanomedicine, vol.3, pp.181-199, 2008.
DOI : 10.2147/IJN.S2736
, Cooperativity between MAPK and PI3K signaling activation is required for glioblastoma pathogenesis, Neuro-Oncology, vol.4, issue.11, pp.1317-1329, 2013.
DOI : 10.1371/journal.pone.0007752
URL : https://academic.oup.com/neuro-oncology/article-pdf/15/10/1317/4136848/not084.pdf
, Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer, Journal of Clinical Investigation, vol.118, pp.3065-3074, 2008.
DOI : 10.1172/JCI34739DS1
, Current Understanding on EGFR and Wnt/??-Catenin Signaling in Glioma and Their Possible Crosstalk, Genes & Cancer, vol.4, issue.11-12, pp.427-446, 2013.
DOI : 10.1177/1947601913503341
URL : http://europepmc.org/articles/pmc3877660?pdf=render
, Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer, Journal of Molecular Signaling, vol.5, p.10, 2010.
DOI : 10.1186/1750-2187-5-10