Association between air pollution and rhinitis incidence in two European cohorts

Emilie Burte 1, 2, * Bénédicte Leynaert 3 Roberto Bono 4 Bert Brunekreef 5, 6 Jean Bousquet 1, 7, 8 Anne-Elie Carsin 2, 9, 10 Kees de Hoogh 11, 12 Bertil Forsberg 13 Frédéric Gormand 14 Joachim Heinrich 15 Jocelyne Just 16, 17 Alessandro Marcon 18, 19 Nino Künzli 11, 12 Mark Nieuwenhuijsen 2, 9, 10 Isabelle Pin 20, 21 Morgane Stempfelet 22 Jordi Sunyer 2, 9, 10 Simona Villani 23 Valérie Siroux 21 Deborah Jarvis 24 Rachel Nadif 1 Bénédicte Jacquemin 1, 2, 9, 10
* Corresponding author
1 VIMA - Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique
2 ISGlobal - Epidemiology & Pulmonology [Barcelona, Spain]
3 Physiopathologie et Epidémiologie des Maladies Respiratoires
4 Department of Public Health and Pediatrics [Turin, Italy]
5 IRAS - Institute for Risk Assessment Sciences [Utrecht, The Netherlands]
6 Julius Center for Health Sciences and Primary Care [Utrecht, The Netherlands]
7 MACVIA-LR - Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon
8 CHU Montpellier
9 CIBER de Epidemiología y Salud Pública (CIBERESP)
10 IMIM - Hospital del Mar Medical Research Institute [Barcelona, Spain]
11 Swiss Tropical and Public Health Institute [Basel]
12 University of Basel [Basel, Switzerland]
13 Environmental and Occupational Medicine - Department of Public Health and Clinical Medicine [Umeå, Sweden]
14 Service de pneumologie [Centre Hospitalier Lyon Sud - HCL]
15 Institute and Outpatient Clinic for Occupational - Social and Environmental Medicine [Munich, Germany]
16 Centre de l'Asthme et des Allergies [CHU Trousseau]
17 UPMC - Université Pierre et Marie Curie - Paris 6 - UFR de Médecine Pierre et Marie Curie
18 Department of Medicine and Public Health
19 Dept of Diagnostics and Public Health - Unit of Epidemiology and Medical Statistics [Verona, Italy]
20 Service de pédiatrie générale et maladies infectieuses [CHU Grenoble]
21 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
22 INVS - Institut de Veille Sanitaire
23 Dept of Public Health - Unit of Biostatistics and Clinical Epidemiology [Pavia, Italy]
24 Faculty of Medicine - School of Public Health [London, UK]
Abstract : BACKGROUND: The association between air pollution and rhinitis is not well established. AIM: The aim of this longitudinal analysis was to study the association between modeled air pollution at the subjects' home addresses and self-reported incidence of rhinitis. METHODS: We used data from 1533 adults from two multicentre cohorts' studies (EGEA and ECRHS). Rhinitis incidence was defined as reporting rhinitis at the second follow-up (2011 to 2013) but not at the first follow-up (2000 to 2007). Annual exposure to NO2, PM10 and PM2.5 at the participants' home addresses was estimated using land-use regression models developed by the ESCAPE project for the 2009-2010 period. Incidence rate ratios (IRR) were computed using Poisson regression. Pooled analysis, analyses by city and meta-regression testing for heterogeneity were carried out. RESULTS: No association between long-term air pollution exposure and incidence of rhinitis was found (adjusted IRR (aIRR) for an increase of 10 μg·m-3 of NO2: 1.00 [0.91-1.09], for an increase of 5 μg·m-3 of PM2.5: 0.88 [0.73-1.04]). Similar results were found in the two-pollutant model (aIRR for an increase of 10 μg·m-3 of NO2: 1.01 [0.87-1.17], for an increase of 5 μg·m-3 of PM2.5: 0.87 [0.68-1.08]). Results differed depending on the city, but no regional pattern emerged for any of the pollutants. CONCLUSIONS: This study did not find any consistent evidence of an association between long-term air pollution and incident rhinitis.
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Emilie Burte, Bénédicte Leynaert, Roberto Bono, Bert Brunekreef, Jean Bousquet, et al.. Association between air pollution and rhinitis incidence in two European cohorts. Environment International, Elsevier, 2018, 115, pp.257 - 266. ⟨10.1016/j.envint.2018.03.021⟩. ⟨inserm-01814823⟩

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