IgE in lupus pathogenesis: Friends or foes?

Abstract : Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving multiple immunological pathways. Recently, several studies have suggested an implication of Immunoglobulin E (IgE) in the pathophysiology of SLE. In the Lyn[−/−] and FcγIIB[−/−] .Yaa lupus mouse models, autoreactive IgE activate basophils, and promote a Th2 environment with, subsequently, production of autoantibodies by plasma cells. Autoreactive IgE has been also shown to play a role in the activation of human plasmacytoid dendritic cells (pDCs), in synergy with IgG, which results in an increase of interferon-alpha (IFN-α) production. In contrast, a protective effect of total non-autoreactive IgE has also been suggested, through a decreased ability of FcεRI-triggered pDCs to secrete IFN-α. This review summarizes in a comprehensive manner the emerging recent literature in the field, and propose new concepts to reconcile the observations.
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Submitted on : Tuesday, June 12, 2018 - 9:15:40 AM
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Jean-François Augusto, Marie-Elise Truchetet, Nicolas Charles, Patrick Blanco, Christophe Richez. IgE in lupus pathogenesis: Friends or foes?. Autoimmunity Reviews, Elsevier, 2018, 17 (4), pp.361 - 365. ⟨10.1016/j.autrev.2017.11.027⟩. ⟨inserm-01813114⟩

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