In vitro activity of tedizolid against the Mycobacterium abscessus complex

Abstract : Infections due to Mycobacterium abscessus carry a poor prognosis since this rapidly growing mycobacterium is intrinsically resistant to most antibiotics. Here, we evaluate the in vitro activity of the new oxazolidinone tedizolid against a collection of 44M. abscessus clinical isolates. The MIC50s and MIC90s of tedizolid (2 and 8μg/mL, respectively) were 2- to 16-fold lower than those of linezolid. There was no difference between the 3M. abscessus subspecies. Time-kill assays did not show any bactericidal activity at 4- and 8-fold the MIC. Combination of tedizolid with clarithromycin was synergistic against 1 out of 6 isolates, while indifferent interactions were observed for tedizolid combined with tigecycline, ciprofloxacin, and amikacin.
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Fabrice Compain, Daria Soroka, Beate Heym, Jean-Louis Gaillard, Jean-Louis Herrmann, et al.. In vitro activity of tedizolid against the Mycobacterium abscessus complex. Diagnostic Microbiology and Infectious Disease, Elsevier, 2018, 90 (3), pp.186 - 189. ⟨10.1016/j.diagmicrobio.2017.11.001⟩. ⟨inserm-01813096⟩

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