gene analysis of prevalence in Italy, Clinical Genetics, vol.9, issue.9, 2015. ,
DOI : 10.1371/journal.pone.0107434
huntington's Disease: The Past, Present, and future search for Disease Modifiers, Yale J Biol Med, vol.86, pp.217-23766742, 2013. ,
GABAergic microcircuits in the neostriatum, Trends in Neurosciences, vol.27, issue.11, pp.662-669, 2004. ,
DOI : 10.1016/j.tins.2004.08.007
Altered excitatory and inhibitory inputs to striatal medium-sized spiny neurons and cortical pyramidal neurons in the Q175 mouse model of Huntington's disease, Journal of Neurophysiology, vol.23, issue.7, pp.2953-2966, 2015. ,
DOI : 10.1038/nm.3514
Therapeutic advances in Huntington's Disease, Movement Disorders, vol.69, issue.11, p.26226924, 2015. ,
DOI : 10.1002/syn.21793
Disease-Specific Induced Pluripotent Stem Cells, Cell, vol.134, issue.5, pp.877-886, 2008. ,
DOI : 10.1016/j.cell.2008.07.041
Preclinical models: Needed in translation? A Pro/Con debate, Movement Disorders, vol.17, issue.11, pp.1391-1396, 2014. ,
DOI : 10.1038/nn.3691
Animal models of Huntington's disease: implications in uncovering pathogenic mechanisms and developing therapies, Acta Pharmacologica Sinica, vol.22, issue.19, pp.1287-1302, 2006. ,
DOI : 10.1038/nature01301
Genetically engineered mesenchymal stem cells reduce behavioral deficits in the YAC 128 mouse model of Huntington's disease, Behavioural Brain Research, vol.214, issue.2, pp.193-200, 2010. ,
DOI : 10.1016/j.bbr.2010.05.023
Mesenchymal stem cell transplantation and DMEM administration in a 3NP rat model of Huntington's disease: Morphological and behavioral outcomes, Behavioural Brain Research, vol.217, issue.2, pp.369-378, 2011. ,
DOI : 10.1016/j.bbr.2010.11.006
Transplantation of GABAergic Cells Derived from Bioreactor-Expanded Human Neural Precursor Cells Restores Motor and Cognitive Behavioral Deficits in a Rodent Model of Huntington's Disease, Cell Transplantation, vol.7, issue.6, pp.2237-2256, 2013. ,
DOI : 10.1038/nrn1919
A Longitudinal Motor Characterisation of the HdhQ111 Mouse Model of Huntington???s Disease, Journal of Huntington's Disease, vol.20, issue.1, pp.149-161, 2016. ,
DOI : 10.1016/j.nbd.2005.01.024
Neural and mesenchymal stem cells in animal models of Huntington???s disease: past experiences and future challenges, Stem Cell Research & Therapy, vol.8, issue.Suppl 2, pp.232-26667114, 2015. ,
DOI : 10.1371/journal.pone.0075682
URL : https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-015-0248-1?site=stemcellres.biomedcentral.com
Is there a place for human fetal-derived stem cells for cell replacement therapy in Huntington's disease?, Neurochemistry International, vol.106, pp.114-121, 2017. ,
DOI : 10.1016/j.neuint.2017.01.016
URL : https://doi.org/10.1016/j.neuint.2017.01.016
Laser Capture Microdissection, Science, vol.55, issue.5289, pp.998-1001, 1996. ,
DOI : 10.1016/S0046-8177(86)80156-3
Identification of expressed genes by laser-mediated manipulation of single cells, Nature Biotechnology, vol.151, issue.8, pp.737-742, 1998. ,
DOI : 10.1016/0169-328X(95)00136-G
Expression of key ion channels in the rat cardiac conduction system by laser capture microdissection and quantitative real-time PCR, Experimental Physiology, vol.88, issue.9, pp.938-945, 2010. ,
DOI : 10.1161/01.RES.88.5.536
Direct isolation and RNA-seq reveal environment-dependent properties of engrafted neural stem/progenitor cells, Nature Communications, vol.176, issue.1, p.23072808, 2012. ,
DOI : 10.2353/ajpath.2010.090839
URL : http://www.nature.com/articles/ncomms2132.pdf
Engrafted Neural Stem/Progenitor Cells Promote Functional Recovery through Synapse Reorganization with Spared Host Neurons after Spinal Cord Injury, Stem Cell Reports, vol.5, issue.2, pp.264-277, 2015. ,
DOI : 10.1016/j.stemcr.2015.06.004
URL : https://doi.org/10.1016/j.stemcr.2015.06.004
Modeling nigrostriatal degeneration in organotypic cultures, a new ex vivo model of Parkinson???s disease, Neuroscience, vol.256, pp.10-22, 2014. ,
DOI : 10.1016/j.neuroscience.2013.10.021
Gene marking of human neural stem/precursor cells using green fluorescent proteins, The Journal of Gene Medicine, vol.173, issue.1, pp.18-29, 2005. ,
DOI : 10.1006/exnr.2001.7750
Establishment and Properties of a Growth Factor-Dependent, Perpetual Neural Stem Cell Line from the Human CNS, Experimental Neurology, vol.161, issue.1, pp.67-84, 2000. ,
DOI : 10.1006/exnr.1999.7237
Survival, Differentiation, and Neuroprotective Mechanisms of Human Stem Cells Complexed With Neurotrophin-3-Releasing Pharmacologically Active Microcarriers in an Ex Vivo Model of Parkinson's Disease, STEM CELLS Translational Medicine, vol.17, issue.6, pp.670-684, 2015. ,
DOI : 10.1007/s10495-011-0679-9
The therapeutic potential of human multipotent mesenchymal stromal cells combined with pharmacologically active microcarriers transplanted in hemi-parkinsonian rats, Biomaterials, vol.32, issue.6, pp.1560-1573, 2011. ,
DOI : 10.1016/j.biomaterials.2010.10.041
URL : https://hal.archives-ouvertes.fr/inserm-00541842
EGF and bFGF pre-treatment enhances neural specification and the response to neuronal commitment of MIAMI cells, Differentiation, vol.80, issue.4-5, pp.213-227, 2010. ,
DOI : 10.1016/j.diff.2010.07.001
Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets, Neuroscience Letters, vol.328, issue.3, pp.261-2643940, 2002. ,
DOI : 10.1016/S0304-3940(02)00529-3
A peptide preparation protects cells in organotypic brain slices against cell death after glutamate intoxication, Journal of Neural Transmission, vol.68, issue.[Suppl], pp.103-110, 1996. ,
DOI : 10.1007/978-3-7091-6467-9_25
Brain-Derived Neurotrophic Factor Restores Synaptic Plasticity in a Knock-In Mouse Model of Huntington's Disease, Journal of Neuroscience, vol.27, issue.16, pp.4424-4434, 2007. ,
DOI : 10.1523/JNEUROSCI.5113-06.2007
Transneuronal propagation of mutant huntingtin contributes to non???cell autonomous pathology in neurons, Nature Neuroscience, vol.19, issue.8, pp.1064-1072, 2014. ,
DOI : 10.1126/science.1227157
Atg4b-Dependent Autophagic Flux Alleviates Huntington???s Disease Progression, PLoS ONE, vol.104, issue.5, pp.68357-23861892, 2013. ,
DOI : 10.1371/journal.pone.0068357.g008
URL : https://doi.org/10.1371/journal.pone.0068357
Graft and host interactions following transplantation of neural stem cells to organotypic striatal cultures, Regenerative Medicine, vol.9, issue.6, pp.901-917, 2010. ,
DOI : 10.1038/nrn2477
A brain slice culture model for studies of endogenous and exogenous precursor cell migration in the rostral migratory stream, Brain Research, vol.1295, pp.1-12, 2009. ,
DOI : 10.1016/j.brainres.2009.07.075
Brain stem slice conditioned medium contains endogenous BDNF and GDNF that affect neural crest boundary cap cells in co-culture, Brain Research, vol.1566, pp.12-23, 2014. ,
DOI : 10.1016/j.brainres.2014.04.006
Characterization of Cortical Neuronal and Glial Alterations during Culture of Organotypic Whole Brain Slices from Neonatal and Mature Mice, PLoS ONE, vol.183, issue.7, pp.22040-21789209, 2011. ,
DOI : 10.1371/journal.pone.0022040.s004
Organotypic brain slice cultures: A review, Neuroscience, vol.305, pp.86-98, 2015. ,
DOI : 10.1016/j.neuroscience.2015.07.086
URL : https://doi.org/10.1016/j.neuroscience.2015.07.086
Huntington Disease in Children: Genotype-Phenotype Correlation, Neuropediatrics, vol.31, issue.4, pp.190-194, 2000. ,
DOI : 10.1055/s-2000-7461
Organotypic hippocampal slice culture from the adult mouse brain: A versatile tool for translational neuropsychopharmacology, Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol.41, pp.36-43, 2013. ,
DOI : 10.1016/j.pnpbp.2012.11.004
An organotypic culture model to study nigro-striatal degeneration, Journal of Neuroscience Methods, vol.188, issue.2, pp.205-212, 2010. ,
DOI : 10.1016/j.jneumeth.2010.02.008
Effects of Donor Age and Brain-Derived Neurotrophic Factor on the Survival of Dopaminergic Neurons and Axonal Growth in Postnatal Rat Nigrostriatal Cocultures, Experimental Neurology, vol.142, issue.2, pp.340-350, 1996. ,
DOI : 10.1006/exnr.1996.0203
Brain-Derived Neurotrophic Factor Mediates Activity-Dependent Dendritic Growth in Nonpyramidal Neocortical Interneurons in Developing Organotypic Cultures, The Journal of Neuroscience, vol.23, issue.13, pp.5662-5673, 2003. ,
DOI : 10.1523/JNEUROSCI.23-13-05662.2003
Neurogenesis and stereological morphometry of calretinin-immunoreactive GABAergic interneurons of the neostriatum, The Journal of Comparative Neurology, vol.23, issue.3, pp.325-339, 2004. ,
DOI : 10.1016/S0896-6273(00)80801-6
Activity-Dependent Regulation of Inhibition via GAD67, Journal of Neuroscience, vol.32, issue.25, pp.8521-8531, 2012. ,
DOI : 10.1523/JNEUROSCI.1245-12.2012
URL : http://www.jneurosci.org/content/jneuro/32/25/8521.full.pdf
Comparison of intrastriatal injections of quinolinic acid and 3-nitropropionic acid for use in animal models of Huntington's disease, Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol.22, issue.7, pp.1217-1240, 1998. ,
DOI : 10.1016/S0278-5846(98)00070-0
Ketamine anaesthesia interferes with the quinolinic acid-induced lesion in a rat model of Huntington's disease, Journal of Neuroscience Methods, vol.179, issue.2, pp.219-223, 2009. ,
DOI : 10.1016/j.jneumeth.2009.01.033
Huntington???s Disease and the Striatal Medium Spiny Neuron: Cell-Autonomous and Non-Cell-Autonomous Mechanisms of Disease, Neurotherapeutics, vol.36, issue.pt 6, pp.270-284, 2012. ,
DOI : 10.1016/j.nbd.2009.08.012
URL : https://link.springer.com/content/pdf/10.1007%2Fs13311-012-0112-2.pdf
An Improved Approach to Prepare Human Brains for Research, Journal of Neuropathology and Experimental Neurology, vol.54, issue.1, pp.42-56, 1995. ,
DOI : 10.1097/00005072-199501000-00006
A critical window of CAG repeat-length correlates with phenotype severity in the R6/2 mouse model of Huntington's disease, Journal of Neurophysiology, vol.22, issue.2, pp.677-691, 2012. ,
DOI : 10.1083/jcb.200306038
Huntington disease: a single-gene degenerative disorder of the striatum, Dialogues Clin Neurosci, vol.18, pp.91-98, 2016. ,
Knock-in mouse models of Huntington???s disease, NeuroRX, vol.12, issue.3, pp.465-470, 2005. ,
DOI : 10.1093/hmg/ddg046
Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington???s Disease: zQ175, PLoS ONE, vol.126, issue.12, pp.49838-23284626, 2012. ,
DOI : 10.1371/journal.pone.0049838.s007
Animal models of Huntington's disease for translation to the clinic: Best practices, Movement Disorders, vol.25, issue.11, pp.1375-1390, 2014. ,
DOI : 10.1002/ana.410250308
Laser capture microdissection in the tissue biorepository, J Biomol Tech JBT, vol.21, pp.120-125, 2010. ,
Laser capture microdissection: Should an ultraviolet or infrared laser be used?, Analytical Biochemistry, vol.439, issue.2, pp.88-98, 2013. ,
DOI : 10.1016/j.ab.2013.04.023
URL : https://doi.org/10.1016/j.ab.2013.04.023
Combining laser capture microdissection with quantitative real-time PCR: Effects of tissue manipulation on RNA quality and gene expression, Journal of Neuroscience Methods, vol.153, issue.1, pp.71-85, 2006. ,
DOI : 10.1016/j.jneumeth.2005.10.010
URL : http://www.gene-quantification.de/kerman-rna-integrity-2006.pdf
Alcohol based fixatives provide excellent tissue morphology, protein immunoreactivity and RNA integrity in paraffin embedded tissue specimens, Acta Histochemica, vol.115, issue.3, pp.279-289, 2013. ,
DOI : 10.1016/j.acthis.2012.08.002
Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture, Nature Protocols, vol.70, issue.2, pp.235-246, 2012. ,
DOI : 10.1074/jbc.M209148200
URL : http://europepmc.org/articles/pmc3505594?pdf=render
Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and <em>Ex vivo</em> Fibroblasts, Journal of Visualized Experiments, issue.86, 2014. ,
DOI : 10.3791/51475
Erratum: An optimised direct lysis method for gene expression studies on low cell numbers, Scientific Reports, vol.7, pp.12859-26242641, 2015. ,
DOI : 10.1038/srep43075
URL : http://www.nature.com/articles/srep43075.pdf
Single-cell gene expression profiling using reverse transcription quantitative real-time PCR. Methods San Diego Calif, pp.282-288, 2010. ,
Genetically Perpetuated Human Neural Stem Cells Engraft and Differentiate into the Adult Mammalian Brain, Molecular and Cellular Neuroscience, vol.16, issue.1, pp.1-13, 2000. ,
DOI : 10.1006/mcne.2000.0854
Nano and microcarriers to improve stem cell behaviour for neuroregenerative medicine strategies: Application to Huntington's disease, Biomaterials, vol.83, pp.347-362, 2016. ,
DOI : 10.1016/j.biomaterials.2015.12.008