BRAF mutations might be more common than supposed in vulvar melanomas

Abstract : Data on BRAF, NRAS and KIT mutations are scarce in patients with vulvo-vaginal melanomas and are associated with important therapeutic issues. We investigated their prevalence in a cohort of patients with female lower genital tract melanomas between 2003 and 2017. Of the 22 patients, 5 (22.7 %) harbored a BRAF mutation which was much higher than the rate of 5% reported in the literature. One patient, who was tested negative on the primary melanoma, had a NRAS mutation in a cutaneous metastasis. Our data provides a rationale for prospective and repeated mutations testing in female lower genital tract melanomas.
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Submitted on : Tuesday, June 5, 2018 - 4:45:00 PM
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Sophie Wylomanski, Marc Denis, Sandrine Théoleyre, Réjane Bouquin, Audrey Vallée, et al.. BRAF mutations might be more common than supposed in vulvar melanomas. Experimental Dermatology, Wiley, 2017, 27 (2), pp.210 - 213. ⟨10.1111/exd.13472⟩. ⟨inserm-01808469⟩

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