Skip to Main content Skip to Navigation
Journal articles

BRAF mutations might be more common than supposed in vulvar melanomas

Abstract : Data on BRAF, NRAS and KIT mutations are scarce in patients with vulvo-vaginal melanomas and are associated with important therapeutic issues. We investigated their prevalence in a cohort of patients with female lower genital tract melanomas between 2003 and 2017. Of the 22 patients, 5 (22.7 %) harbored a BRAF mutation which was much higher than the rate of 5% reported in the literature. One patient, who was tested negative on the primary melanoma, had a NRAS mutation in a cutaneous metastasis. Our data provides a rationale for prospective and repeated mutations testing in female lower genital tract melanomas.
Document type :
Journal articles
Complete list of metadata

Cited literature [6 references]  Display  Hide  Download
Contributor : Elizabeth Bernardo Connect in order to contact the contributor
Submitted on : Tuesday, June 5, 2018 - 4:45:00 PM
Last modification on : Wednesday, November 3, 2021 - 4:37:36 AM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document



Sophie Wylomanski, Marc Denis, Sandrine Théoleyre, Réjane Bouquin, Audrey Vallée, et al.. BRAF mutations might be more common than supposed in vulvar melanomas. Experimental Dermatology, Wiley, 2017, 27 (2), pp.210 - 213. ⟨10.1111/exd.13472⟩. ⟨inserm-01808469⟩



Record views