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Article Dans Une Revue Experimental & Molecular Medicine Année : 2018

The wide utility of rabbits as models of human diseases

1 CIBIO, InBIO, Research Network in Biodiversity and Evolutionary Biology
2 Universidade do Porto = University of Porto
3 Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde - CESPU [Gandra, Portugal]
4 Max von Pettenkofer Institute and Gene Center
5 Laboratory of Cellular and Molecular Immunology
6 Department of Molecular Biology and Biochemistry
7 Institute for Immunology
8 Department of Medicine
9 Departments of Pathology, Microbiology and Immunology, and Comparative Medicine
10 Institute of Biomedicine (IBIOMED) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd)
11 Departments of Medicine and Global Health
12 Bill & Melinda Gates Foundation [Seattle]
13 Department of Microbiology and Immunology
14 Department of Biochemistry and Molecular Pharmacology
15 CRCINA-ÉQUIPE 5 - Host-Pathogen Interactions in the Regulation of Immune Responses
16 The Biodesign Institute, Center for Immunotherapy, Vaccines, and Virotherapy
17 Department of Microbiology and Immunology
18 Department of Anatomy and Unit for Multidisciplinary Research in Biomedicine (UMIB)
19 Division of Infectious Diseases, Department of Medicine
20 PHRI - Public Health Research Institute [Newark]
21 Tubercolosis Research Section, Laboratory of Clinical Infectious Diseases, Division of Intramural Research
22 Institute of Infectious Disease and Molecular Medicine, Department of Clinical Laboratory Sciences
23 Laboratory of Immune System Biology
Jia Liu
Shan Lu
  • Fonction : Auteur

Résumé

Studies using the European rabbit Oryctolagus cuniculus contributed to elucidating numerous fundamental aspects of antibody structure and diversification mechanisms and continue to be valuable for the development and testing of therapeutic humanized polyclonal and monoclonal antibodies. Additionally, during the last two decades, the use of the European rabbit as an animal model has been increasingly extended to many human diseases. This review documents the continuing wide utility of the rabbit as a reliable disease model for development of therapeutics and vaccines and studies of the cellular and molecular mechanisms underlying many human diseases. Examples include syphilis, tuberculosis, HIV-AIDS, acute hepatic failure and diseases caused by noroviruses, ocular herpes, and papillomaviruses. The use of rabbits for vaccine development studies, which began with Louis Pasteur's rabies vaccine in 1881, continues today with targets that include the potentially blinding HSV-1 virus infection and HIV-AIDS. Additionally, two highly fatal viral diseases, rabbit hemorrhagic disease and myxomatosis, affect the European rabbit and provide unique models to understand co-evolution between a vertebrate host and viral pathogens.

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Cancer
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Dates et versions

inserm-01804663 , version 1 (01-06-2018)

Identifiants

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Pedro J Esteves, Joana Abrantes, Hanna-Mari Baldauf, Lbachir Benmohamed, Yuxing Chen, et al.. The wide utility of rabbits as models of human diseases. Experimental & Molecular Medicine, 2018, 50 (5), pp.66. ⟨10.1038/s12276-018-0094-1⟩. ⟨inserm-01804663⟩
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