Duchenne Muscular Dystrophy, 2015. ,
DOI : 10.1093/med/9780199681488.001.0001
Codon and mRNA Sequence Optimization of Microdystrophin Transgenes Improves Expression and Physiological Outcome in Dystrophic mdx Mice Following AAV2/8 Gene Transfer, Molecular Therapy, vol.16, issue.11, pp.1825-1832, 2008. ,
DOI : 10.1038/mt.2008.186
URL : https://doi.org/10.1038/mt.2008.186
Forelimb Treatment in a Large Cohort of Dystrophic Dogs Supports Delivery of a Recombinant AAV for Exon Skipping in Duchenne Patients, Molecular Therapy, vol.22, issue.11, pp.1923-1935, 2014. ,
DOI : 10.1038/mt.2014.151
AAV Genome Loss From Dystrophic Mouse Muscles During AAV-U7 snRNA-mediated Exon-skipping Therapy, Molecular Therapy, vol.21, issue.8, pp.1551-1558, 2013. ,
DOI : 10.1038/mt.2013.121
DNA Damage, Somatic Aneuploidy, and Malignant Sarcoma Susceptibility in Muscular Dystrophies, PLoS Genetics, vol.6, issue.4, p.1002042, 2011. ,
DOI : 10.1371/journal.pgen.1002042.s001
URL : http://doi.org/10.1371/journal.pgen.1002042
Nitric oxide deficiency determines global chromatin changes in Duchenne muscular dystrophy, The FASEB Journal, vol.23, issue.7, pp.2131-2141, 2009. ,
DOI : 10.1016/j.bbamcr.2006.09.018
HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment, Proceedings of the National Academy of Sciences, vol.192, issue.2, pp.19183-19187, 2008. ,
DOI : 10.1016/0003-2697(91)90534-Z
URL : http://www.pnas.org/content/105/49/19183.full.pdf
Oxidative Damage in Muscular Dystrophy Correlates with the Severity of the Pathology: Role of Glutathione Metabolism, Neurochemical Research, vol.33, issue.2, pp.885-898, 2012. ,
DOI : 10.1247/csf.08022
Adeno-Associated Virus Vector Genomes Persist as Episomal Chromatin in Primate Muscle, Journal of Virology, vol.82, issue.16, pp.7875-7885, 2008. ,
DOI : 10.1128/JVI.00649-08
URL : http://jvi.asm.org/content/82/16/7875.full.pdf
Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function, Genes & Development, vol.21, issue.15, pp.1833-1856, 2007. ,
DOI : 10.1101/gad.1566807
URL : http://genesdev.cshlp.org/content/21/15/1833.full.pdf
Regulation of cytoplasmic mRNA decay, Nature Reviews Genetics, vol.133, issue.4, pp.246-259, 2012. ,
DOI : 10.1016/j.cell.2008.02.031
URL : http://www.nature.com/nrg/journal/v13/n6/pdf/nrg3254.pdf
Oxidative stress in muscular dystrophy: from generic evidence to specific sources and targets, Journal of Muscle Research and Cell Motility, vol.71, issue.2, pp.23-36, 2014. ,
DOI : 10.1016/j.cardiores.2006.02.019
Patients with dystrophinopathy show evidence of increased oxidative stress, Free Radical Biology and Medicine, vol.34, issue.9, pp.1217-1220, 2003. ,
DOI : 10.1016/S0891-5849(03)00141-2
Sarcolemmal Damage in Dystrophin Deficiency Is Modulated by Synergistic Interactions between Mechanical and Oxidative/Nitrosative Stresses, The American Journal of Pathology, vol.168, issue.4, pp.1276-87, 2006. ,
DOI : 10.2353/ajpath.2006.050683
URL : http://europepmc.org/articles/pmc1606574?pdf=render
Long-term pharmacologically regulated expression of erythropoietin in primates following AAV-mediated gene transfer, Blood, vol.105, issue.4, pp.1424-1430, 2005. ,
DOI : 10.1182/blood-2004-06-2501
URL : http://www.bloodjournal.org/content/bloodjournal/105/4/1424.full.pdf
Relative persistence of AAV serotype 1 vector genomes in dystrophic muscle, Genetic Vaccines and Therapy, vol.6, issue.1, p.14, 2008. ,
DOI : 10.1186/1479-0556-6-14
URL : https://gvt-journal.biomedcentral.com/track/pdf/10.1186/1479-0556-6-14
Differential Effects of DNA Double-Strand Break Repair Pathways on Single-Strand and Self-Complementary Adeno-Associated Virus Vector Genomes, Journal of Virology, vol.84, issue.17, pp.8673-8682, 2010. ,
DOI : 10.1128/JVI.00641-10
URL : http://jvi.asm.org/content/84/17/8673.full.pdf
Processing of recombinant AAV genomes occurs in specific nuclear structures that overlap with foci of DNA-damage-response proteins, Journal of Cell Science, vol.121, issue.3, pp.349-357, 2008. ,
DOI : 10.1242/jcs.003632
Terminal Differentiation of Cardiac and Skeletal Myocytes Induces Permissivity to AAV Transduction by Relieving Inhibition Imposed by DNA Damage Response Proteins, Molecular Therapy, vol.20, issue.11, pp.2087-2097, 2012. ,
DOI : 10.1038/mt.2012.144
URL : https://doi.org/10.1038/mt.2012.144
Hairpin-end conformation of adeno-associated virus genome determines interactions with DNA-repair pathways, Gene Therapy, vol.68, issue.6, pp.686-693, 2013. ,
DOI : 10.1016/j.ymeth.2006.06.010
URL : http://europepmc.org/articles/pmc3578132?pdf=render
TNF Inhibits Notch-1 in Skeletal Muscle Cells by Ezh2 and DNA Methylation Mediated Repression: Implications in Duchenne Muscular Dystrophy, PLoS ONE, vol.68, issue.3, p.12479, 2010. ,
DOI : 10.1371/journal.pone.0012479.g005
URL : https://doi.org/10.1371/journal.pone.0012479
DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin, Proceedings of the National Academy of Sciences, vol.18, issue.7, pp.9169-9174, 2014. ,
DOI : 10.1038/nsmb.2077
URL : http://www.pnas.org/content/111/25/9169.full.pdf
Mechanistic Links Between ATM and Histone Methylation Codes During DNA Repair, Prog Mol Biol Transl Sci, vol.110, pp.263-288, 2012. ,
DOI : 10.1016/B978-0-12-387665-2.00010-9
Oxidative stress and predominant Abeta42(43) deposition in myopathies with rimmed vacuoles, Acta Neuropathol, vol.105, pp.581-585, 2003. ,
The Identification and Characterization of Oxidized RNAs in Alzheimer's Disease, The Journal of Neuroscience, vol.23, issue.12, pp.4913-4921, 2003. ,
DOI : 10.1523/JNEUROSCI.23-12-04913.2003
RNA modifications by oxidation: A novel disease mechanism?, Free Radical Biology and Medicine, vol.52, issue.8, pp.1353-1361, 2012. ,
DOI : 10.1016/j.freeradbiomed.2012.01.009
Direct Strand Scission from a Nucleobase Radical in RNA, Journal of the American Chemical Society, vol.132, issue.11, pp.3668-3669, 2010. ,
DOI : 10.1021/ja100281x
URL : http://europepmc.org/articles/pmc2845440?pdf=render
Oxidized messenger RNA induces translation errors, Proceedings of the National Academy of Sciences, vol.85, issue.1-2, pp.66-71, 2007. ,
DOI : 10.1016/S0169-328X(00)00250-3
URL : http://www.pnas.org/content/104/1/66.full.pdf
Messenger RNA oxidation is an early event preceding cell death and causes reduced protein expression, The FASEB Journal, vol.21, issue.11, pp.2753-2764, 2007. ,
DOI : 10.1016/S0959-437X(02)00297-6
URL : http://www.fasebj.org/content/21/11/2753.full.pdf
Messenger RNA Oxidation Occurs Early in Disease Pathogenesis and Promotes Motor Neuron Degeneration in ALS, PLoS ONE, vol.21, issue.2, p.2849, 2008. ,
DOI : 10.1371/journal.pone.0002849.t001
URL : https://doi.org/10.1371/journal.pone.0002849
The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments, Clinical Chemistry, vol.55, issue.4, pp.611-622, 2009. ,
DOI : 10.1373/clinchem.2008.112797
URL : http://clinchem.aaccjnls.org/content/clinchem/55/4/611.full.pdf
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