Skip to Main content Skip to Navigation
Journal articles

Surfactant protein D, a clinical biomarker for chronic obstructive pulmonary disease with excellent discriminant values: AKIKI et al: SP-D, a clinical biomarker for COPD with excellent discriminant values

Abstract : Biological markers can help to better identify a disease or refine its diagnosis. In the present study, the association between surfactant protein D (SP-D) and chronic obstructive pulmonary disease (COPD) was studied among subjects consulting for respiratory diseases or symptoms and was compared with C-reactive protein (CRP) and fibrinogen. A further aim of this study was to identify the optimal cut-off point of SP-D able to discriminate COPD patients. A case-control study including 90 COPD patients, 124 asthma patients and 180 controls was conducted. Standardized questionnaires were administered and lung function tests were performed. Biological markers were measured in blood samples according to standardized procedures. The association between SP-D and COPD was investigated using logistic regression models. Receiver-operating characteristic curves were used for threshold identification. SP-D levels above the median value were positively associated with COPD [adjusted odds ratio (OR)=3.86, 95% confidence interval (CI): 1.51-9.85, P=0.005). No associations with COPD or asthma were found for CRP or fibrinogen levels. Scores for COPD diagnosis in all COPD patients or ever-smoker COPD patients were identified (sensitivity, 76.4 and 77.8%; specificity, 89.3 and 88.5%, respectively). The results indicate that SP-D can differentiate COPD from other respiratory symptoms or diseases. Used with socio-demographic characteristics and respiratory symptoms, SP-D is able to discriminate COPD patients from controls, particularly among smokers.
Document type :
Journal articles
Complete list of metadatas

Cited literature [35 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01764320
Contributor : Beatrice Faraldo <>
Submitted on : Wednesday, April 11, 2018 - 6:30:47 PM
Last modification on : Wednesday, July 15, 2020 - 11:52:04 AM

File

akiki_Manuscript_SPD (1).pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Zeina Akiki, Dalia Fakih, Rania Jounblat, Soulaima Chamat, Mirna Waked, et al.. Surfactant protein D, a clinical biomarker for chronic obstructive pulmonary disease with excellent discriminant values: AKIKI et al: SP-D, a clinical biomarker for COPD with excellent discriminant values. Experimental and Therapeutic Medicine, [Athens : Spandidos Pub.], 2016, 11 (3), pp.723 - 730. ⟨10.3892/etm.2016.2986⟩. ⟨inserm-01764320⟩

Share

Metrics

Record views

161

Files downloads

272