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Journal articles
Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation
Bertrand Calippe
1
Sébastien Augustin
1
Fanny Beguier
1
Hugo Charles-Messance
1
Lucie Poupel
2, 3
Jean-Baptiste Conart
1
Shulong Hu
1
Sophie Lavalette
1
Alexandre Fauvet
1
Julie Rayes
4
Olivier Levy
1
William Raoul
1
Catherine Fitting
5
Thomas Denèfle
6, 3, 7
Matthew Pickering
8
Claire Harris
9
Sylvie Jorieux
10
Patrick Sullivan
11
José-Alain Sahel
1
Philippe Karoyan
6, 3, 7
Przemyslaw Sapieha
12
Xavier Guillonneau
1
Emmanuel Gautier
2, 3
Florian Sennlaub
1, *
*
Corresponding author
Bertrand Calippe 1
Author
Sébastien Augustin 1
Author
Fanny Beguier 1
Author
Hugo Charles-Messance 1
Author
Lucie Poupel 2, 3
Author
Jean-Baptiste Conart 1
Author IdHAL : jean-baptiste-conart
Shulong J. Hu 1
Author
Sophie Lavalette 1
Author
Alexandre Fauvet 1
Author
Julie Rayes 4
Author
Olivier Levy 1
Author
William Raoul 1
Author IdHAL : william-raoul
Catherine Fitting 5
Author
Thomas Denèfle 6, 3, 7
Author
Matthew C Pickering 8
Author
Claire Harris 9
Author
Sylvie Jorieux 10
Author
Patrick Sullivan 11
Author
José-Alain Sahel 1
Author
Philippe Karoyan 6, 3, 7
Author
Przemyslaw Sapieha 12
Author
Xavier Guillonneau 1
Author
Emmanuel Gautier 2, 3
Author
Florian Sennlaub 1
Correspondent author
1
Institut de la Vision (17 Rue Moreau, 75012 Paris - France)
- UPMC - Université Pierre et Marie Curie - Paris 6 : UM80 (4 place Jussieu - 75005 Paris - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U968 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7210 (France)
2
ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (Faculté de Médecine - 91 boulevard de l'Hôpital 75634 Paris Cedex 13 - France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1166 (101, rue de Tolbiac, 75013 Paris - France)
- CHU Pitié-Salpêtrière [AP-HP] (47-83 Boulevard de l'Hôpital, 75013 Paris - France)
- Sorbonne Université (France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
3
Sorbonne Université (France)
4
CRC (UMR_S 872) - Centre de Recherche des Cordeliers (CRBM des Cordeliers 15, rue de l'ecole de medecine batiment E 75270 Paris cedex 06 - France)
- UPD5 - Université Paris Descartes - Paris 5 : U872 (12, rue de l'École de Médecine - 75270 Paris cedex 06 - France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U872 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR 872 (France)
5
Cytokines et Inflammation (Département Infection et épidémiologie, 25-28 rue du Docteur Roux, F-75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
6
LBM UMR 7203 - Laboratoire des biomolécules (ENS - Laboratoire des BioMolécules
24 rue Lhomond
75005 Paris - )
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
- Département de Chimie - ENS Paris (24 rue Lhomond
75132 Paris Cedex 05 - France)
- ENS Paris - École normale supérieure - Paris (45, Rue d'Ulm - 75230 Paris cedex 05 - France)
- PSL - Université Paris sciences et lettres (60 rue Mazarine 75006 Paris - France)
- ENS Paris - École normale supérieure - Paris (45, Rue d'Ulm - 75230 Paris cedex 05 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR 7203 (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale (101, rue de Tolbiac, 75013 Paris - France)
7
FR 2769 - Chimie Moléculaire de Paris Centre (4 place Jussieu, Bâtiment F/74 - 2ème étage 75252 Paris Cedex 05, - France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
- ESPCI Paris - Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (10 rue Vauquelin, 75231 Paris cedex 05 - France)
- PSL - Université Paris sciences et lettres (60 rue Mazarine 75006 Paris - France)
- ENSCP - Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (11, rue Pierre et Marie Curie
75231 Paris Cedex 05 - France)
- PSL - Université Paris sciences et lettres (60 rue Mazarine 75006 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : FR2769 (France)
- ENS Paris - École normale supérieure - Paris (45, Rue d'Ulm - 75230 Paris cedex 05 - France)
- PSL - Université Paris sciences et lettres (60 rue Mazarine 75006 Paris - France)
8
Department of Medicine - Centre for Complement and Inflammation Research [London, UK] (London W12 0NN. - United Kingdom)
- Imperial College London (South Kensington Campus, London SW7 2AZ - United Kingdom)
9
Institute of Infection & Immunity [Cardiff, UK] ( School of Medicine - Cardiff CF10 3XQ - United Kingdom)
- Cardiff University (Cardiff Wales CF10 3AT - United Kingdom)
10
Laboratoire Français du fractionnement et des Biotechnologies [Lille] (59000 Lille. - France)
- LFB Biotechnologies (France)
11
Centers for Aging and Geriatric Research Education and Clinical Center - Department of Medicine [Durham, NC, USA] (Durham, NC 27710. - United States)
- Duke University [Durham] (Durham, NC 27708 - United States)
- Durham Veteran Affairs Medical Center [Durham, NC, USA] (Durham, NC 27710. - United States)
12
Department of Ophthalmology [Montreal, QC, Canada] (Montreal, QC H3T 1J4. - Canada)
- University of Montreal [Canada] (Montreal, QC H3T 1J4. - Canada)
- Maisonneuve-Rosemont Hospital Research Centre [Montreal, QC, Canada] (Montreal, QC H3T 1J4. - Canada)
Abstract : Variants of the CFH gene, encoding complement factor H (CFH), show strong association with age-related macular degeneration (AMD), a major cause of blindness. Here, we used murine models of AMD to examine the contribution of CFH to disease etiology. Cfh deletion protected the mice from the pathogenic subretinal accumulation of mononuclear phagocytes (MP) that characterize AMD and showed accelerated resolution of inflammation. MP persistence arose secondary to binding of CFH to CD11b, which obstructed the homeostatic elimination of MPs from the subretinal space mediated by thrombospsondin-1 (TSP-1) activation of CD47. The AMD-associated CFH(H402) variant markedly increased this inhibitory effect on microglial cells, supporting a causal link to disease etiology. This mechanism is not restricted to the eye, as similar results were observed in a model of acute sterile peritonitis. Pharmacological activation of CD47 accelerated resolution of both subretinal and peritoneal inflammation, with implications for the treatment of chronic inflammatory disease.
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Journal articles
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https://www.hal.inserm.fr/inserm-01755551
Contributor : William Raoul <>
Submitted on : Friday, March 30, 2018 - 4:36:23 PM
Last modification on : Saturday, April 24, 2021 - 6:40:05 PM
Contributor : William Raoul <>
Submitted on : Friday, March 30, 2018 - 4:36:23 PM
Last modification on : Saturday, April 24, 2021 - 6:40:05 PM
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Identifiers
- HAL Id : inserm-01755551, version 1
- DOI : 10.1016/j.immuni.2017.01.006
- PUBMED : 28228282
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INSERM | PASTEUR | CNRS | UPMC | ENS-PARIS | ICAN | CORDELIERS | LBM | U968 | USPC | UNIV-PARIS5 | LBM-E1 | MICHEM | SORBONNE-UNIVERSITE | ENSCP | INC-CNRS | PARISTECH | SU-MEDECINE | SU-SCIENCES | UNIV-PARIS | ESPCI-PSL | PSL | ESPCI | SU-TI
Citation
Bertrand Calippe, Sébastien Augustin, Fanny Beguier, Hugo Charles-Messance, Lucie Poupel, et al.. Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation. Immunity, Elsevier, 2017, 46 (2), pp.261 - 272. ⟨10.1016/j.immuni.2017.01.006⟩. ⟨inserm-01755551⟩
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