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Sex-specific metabolic alterations induced by environmental pollutants

Abstract : Diabetes and obesity are the biggest public health challenge and the current prevalence of these chronic diseases has reached epidemic proportions worldwide. Apart from genetic alterations and lifestyle, exposure to environmental chemicals has emerged as a new cause of metabolic diseases. Notably, several compounds that mimic or oppose hormone activity defined as endocrine disruptors (EDs), may exert metabolic disturbances through interfering with the regulatory roles of the sex steroids (among other hormones) in energy homeostasis. However, most studies to date have investigated the metabolic impact of EDs on males and there is a lack of information regarding the metabolic impact of endocrine disruptors in females. There is as well a paucity of data for both sexes related to the metabolic impact resulting from the exposure to a mixture of EDs which is a more realistic scenario than the exposure to chemicals individually. Hopefully, conducting studies on both sexes in situations of multi-exposure to chemicals will help at better understanding the sex-biased mechanisms linked to endocrine disruption that could be helpful to improve and personalize treatments of diseases for which obesity is a risk factor, such as the metabolic syndrome and the hormono-dependent cancers.
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Submitted on : Monday, March 26, 2018 - 4:50:09 PM
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Brigitte Le Magueresse-Battistoni, Hubert Vidal, Danielle Naville. Sex-specific metabolic alterations induced by environmental pollutants. Current Opinion in Toxicology, [Amsterdam] : Elsevier B.V., [2016]-, 2018, 8, pp.1 - 7. ⟨10.1016/j.cotox.2017.11.007⟩. ⟨inserm-01743795⟩



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