L. Torre, F. Bray, R. Siegel, J. Ferlay, J. Lortet-tieulent et al., Global cancer statistics, 2012, Global cancer statistics, pp.87-108, 2012.
DOI : 10.1038/nrc1948

M. Janssen-heijnen and J. Coebergh, Trends in incidence and prognosis of the histological subtypes of lung cancer in North America, Lung cancer, vol.31, pp.2-3, 2001.

D. Lewis, D. Check, N. Caporaso, W. Travis, and S. Devesa, US lung cancer trends by histologic type, Cancer, vol.369, issue.suppl 5, pp.2883-92, 2014.
DOI : 10.1056/NEJMoa1301851

URL : http://onlinelibrary.wiley.com/doi/10.1002/cncr.28749/pdf

D. Youlden, S. Cramb, and P. Baade, The International Epidemiology of Lung Cancer: Geographical Distribution and Secular Trends, Journal of Thoracic Oncology, vol.3, issue.8, pp.819-850, 2008.
DOI : 10.1097/JTO.0b013e31818020eb

F. Bray and E. Weiderpass, Lung cancer mortality trends in 36 European countries: secular trends and birth cohort patterns by sex and region 1970??????2007, International Journal of Cancer, vol.101, issue.6, pp.1454-66, 2010.
DOI : 10.1016/S0140-6736(00)82038-3

M. Thun, R. Peto, J. Boreham, and A. Lopez, Stages of the cigarette epidemic on entering its second century, Tobacco Control, vol.21, issue.2, pp.96-101, 2012.
DOI : 10.1136/tobaccocontrol-2011-050294

S. Devesa, F. Bray, A. Vizcaino, and D. Parkin, International lung cancer trends by histologic type: Male:Female differences diminishing and adenocarcinoma rates rising, International Journal of Cancer, vol.15, issue.2, pp.294-303, 2005.
DOI : 10.1093/acprof:oso/9780198508564.001.0001

URL : http://onlinelibrary.wiley.com/doi/10.1002/ijc.21183/pdf

K. Straif, A. Cohen, and J. Samet, Air Pollution and Cancer: IARC Scientific Publication No. 161, International Agency for Research on Cancer, 2013.

P. Duan, C. Quan, C. Hu, J. Zhang, F. Xie et al., Nonlinear dose???response relationship between radon exposure and the risk of lung cancer, European Journal of Cancer Prevention, vol.24, issue.4, pp.267-77, 2015.
DOI : 10.1097/CEJ.0000000000000066

Y. Wang, F. Li, Z. Wang, T. Qiu, Y. Shen et al., Fruit and vegetable consumption and risk of lung cancer: A dose???response meta-analysis of prospective cohort studies, Lung Cancer, vol.88, issue.2, pp.124-154, 2015.
DOI : 10.1016/j.lungcan.2015.02.015

A. Vieira, L. Abar, S. Vingeliene, D. Chan, D. Aune et al., Fruits, vegetables and lung cancer risk: a systematic review and meta-analysis, Annals of Oncology, vol.129, issue.(5), pp.81-96, 2016.
DOI : 10.1158/1055-9965.EPI-05-0236

K. Basen-engquist and M. Chang, Obesity and Cancer Risk: Recent Review and Evidence, Current Oncology Reports, vol.13, issue.1, pp.71-77, 2011.
DOI : 10.7326/0003-4819-142-6-200503150-00008

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786180/pdf

L. Machova, L. Cizek, D. Horakova, J. Koutna, J. Lorenc et al., Association between obesity and cancer incidence in the population of the district Sumperk, Czech Republic, Onkologie, vol.30, issue.11, pp.538-580, 2007.

H. Kollarova, L. Machova, D. Horakova, L. Cizek, G. Janoutova et al., Is obesity a preventive factor for lung cancer?, Neoplasma, vol.55, issue.1, pp.71-74, 2008.

C. Tarnaud, F. Guida, A. Papadopoulos, S. Cenee, D. Cyr et al., Body mass index and lung cancer risk: results from the ICARE study, a large, population-based case???control study, Cancer Causes & Control, vol.100, issue.3, pp.1113-1139, 2012.
DOI : 10.1017/S0007114508911600

M. El-zein, M. Parent, B. Nicolau, A. Koushik, J. Siemiatycki et al., Body mass index, lifetime smoking intensity and lung cancer risk, International Journal of Cancer, vol.105, issue.7, pp.1721-1752, 2013.
DOI : 10.1038/bjc.2011.254

URL : https://hal.archives-ouvertes.fr/pasteur-01130942

E. Calle, C. Rodriguez, K. Walker-thurmond, and M. Thun, Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults, New England Journal of Medicine, vol.348, issue.17, pp.1625-1663, 2003.
DOI : 10.1056/NEJMoa021423

G. Kabat, A. Miller, and T. Rohan, Body Mass Index and Lung Cancer Risk in Women, Epidemiology, vol.18, issue.5, pp.607-619, 2007.
DOI : 10.1097/EDE.0b013e31812713d1

G. Kabat, M. Kim, J. Hunt, R. Chlebowski, and T. Rohan, Body Mass Index and Waist Circumference in Relation to Lung Cancer Risk in the Women's Health Initiative, American Journal of Epidemiology, vol.122, issue.7, pp.158-69, 2008.
DOI : 10.1002/ijc.23198

L. Smith, L. Brinton, M. Spitz, T. Lam, Y. Park et al., Body Mass Index and Risk of Lung Cancer Among Never, Former, and Current Smokers, JNCI: Journal of the National Cancer Institute, vol.125, issue.1, pp.778-89, 2012.
DOI : 10.1093/oxfordjournals.aje.a114494

T. Bethea, L. Rosenberg, C. M. , O. Connor, G. Adams-campbell et al., Obesity in relation to lung cancer incidence in African American women, Cancer Causes & Control, vol.15, issue.7, pp.1695-703, 2013.
DOI : 10.1093/jnci/djs381

R. Everatt, D. Virviciute, I. Kuzmickiene, and A. Tamosiunas, Body mass index, cholesterol level and risk of lung cancer in Lithuanian men, Lung Cancer, vol.85, issue.3, pp.361-366, 2014.
DOI : 10.1016/j.lungcan.2014.07.009

L. Guo, N. Li, G. Wang, K. Su, F. Li et al., Body mass index and cancer incidence:a prospective cohort study in northern China, Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 2014, pp.231-236

P. Knekt, M. Heliovaara, A. Rissanen, A. Aromaa, R. Seppanen et al., Leanness and lung-cancer risk, International Journal of Cancer, vol.299, issue.2, pp.208-221, 1991.
DOI : 10.1159/000387586

W. Koh, J. Yuan, R. Wang, H. Lee, and M. Yu, Body mass index and smoking-related lung cancer risk in the Singapore Chinese Health Study, British Journal of Cancer, vol.12, issue.3, pp.610-614, 2010.
DOI : 10.1158/0008-5472.CAN-08-4330

Y. Yang, J. Dong, K. Sun, L. Zhao, F. Zhao et al., Obesity and incidence of lung cancer: A meta-analysis, International Journal of Cancer, vol.115, issue.5, pp.1162-1171, 2013.
DOI : 10.1093/oxfordjournals.aje.a113294

P. Duan, C. Hu, C. Quan, X. Yi, W. Zhou et al., Body mass index and risk of lung cancer: systematic review and doseresponse meta-analysis. Sci Rep, p.16938, 2015.

D. Jacobs, . Jr, and S. Gottenborg, Smoking and weight: the Minnesota Lipid Research Clinic., American Journal of Public Health, vol.71, issue.4, pp.391-397, 1981.
DOI : 10.2105/AJPH.71.4.391

S. Wannamethee, A. Shaper, and M. Walker, Weight change, body weight and mortality: the impact of smoking and ill health, International Journal of Epidemiology, vol.30, issue.4, pp.777-86, 2001.
DOI : 10.1093/aje/141.4.312

S. Henley, W. Flanders, A. Manatunga, and M. Thun, Leanness and Lung Cancer Risk: Fact or Artifact?, Epidemiology, vol.13, issue.3, pp.268-76, 2002.
DOI : 10.1097/00001648-200205000-00006

URL : http://pdfs.journals.lww.com/epidem/2002/05000/Leanness_and_Lung_Cancer_Risk__Fact_or_Artifact_.6.pdf?token=method|ExpireAbsolute;source|Journals;ttl|1503287724914;payload|mY8D3u1TCCsNvP5E421JYK6N6XICDamxByyYpaNzk7FKjTaa1Yz22MivkHZqjGP4kdS2v0J76WGAnHACH69s21Csk0OpQi3YbjEMdSoz2UhVybFqQxA7lKwSUlA502zQZr96TQRwhVlocEp/sJ586aVbcBFlltKNKo+tbuMfL73hiPqJliudqs17cHeLcLbV/CqjlP3IO0jGHlHQtJWcICDdAyGJMnpi6RlbEJaRheGeh5z5uvqz3FLHgPKVXJzdwDZp1SIHq/Hx9d3XeFlYNkbSdSvQN82sphAuHhzaLSM=;hash|ijw3d8ePmgqqRS3kdlRGYA==

T. Lam, S. Moore, L. Brinton, L. Smith, A. Hollenbeck et al., Anthropometric Measures and Physical Activity and the Risk of Lung Cancer in Never-Smokers: A Prospective Cohort Study, PLoS ONE, vol.15, issue.8, p.70672, 2013.
DOI : 10.1371/journal.pone.0070672.s001

K. Flegal, B. Graubard, D. Williamson, and R. Cooper, Reverse Causation and Illness-related Weight Loss in Observational Studies of Body Weight and Mortality, American Journal of Epidemiology, vol.146, issue.1, pp.1-9, 2011.
DOI : 10.1093/oxfordjournals.aje.a009185

P. Brennan, J. Mckay, L. Moore, D. Zaridze, A. Mukeria et al., Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype, International Journal of Epidemiology, vol.16, issue.1, pp.971-976, 2009.
DOI : 10.1093/hmg/ddl436

C. Gao, C. Patel, K. Michailidou, U. Peters, J. Gong et al., Mendelian randomization study of adiposity-related traits and risk of breast, ovarian, prostate, lung and colorectal cancer, International Journal of Epidemiology, vol.45, issue.3, pp.896-908, 2016.
DOI : 10.1079/PHN2001322

R. Carreras-torres, P. Haycock, C. Relton, R. Martin, G. Smith et al., The causal relevance of body mass index in different histological types of lung cancer: A Mendelian randomization study, Scientific Reports, vol.15, issue.1, p.31121, 2016.
DOI : 10.1038/nrc3967

M. Kanashiki, T. Sairenchi, Y. Saito, H. Ishikawa, H. Satoh et al., Body Mass Index and Lung Cancer, Chest, vol.128, issue.3, pp.1490-1496, 2005.
DOI : 10.1378/chest.128.3.1490

S. Jee, J. Yun, E. Park, E. Cho, I. Park et al., Body mass index and cancer risk in Korean men and women, International Journal of Cancer, vol.118, issue.8, pp.1892-1898, 2008.
DOI : 10.1002/ijc.23719

J. Olson, P. Yang, K. Schmitz, R. Vierkant, J. Cerhan et al., Differential Association of Body Mass Index and Fat Distribution with Three Major Histologic Types of Lung Cancer: Evidence from a Cohort of Older Women, American Journal of Epidemiology, vol.156, issue.7
DOI : 10.1093/aje/kwf084

S. Oh, Y. Yoon, and S. Shin, Effects of Excess Weight on Cancer Incidences Depending on Cancer Sites and Histologic Findings Among Men: Korea National Health Insurance Corporation Study, Journal of Clinical Oncology, vol.23, issue.21, pp.4742-54, 2005.
DOI : 10.1200/JCO.2005.11.726

E. Riboli and R. Kaaks, The EPIC Project: rationale and study design. European Prospective Investigation into Cancer and Nutrition, International Journal of Epidemiology, vol.26, issue.90001, pp.6-14, 1997.
DOI : 10.1093/ije/26.suppl_1.S6

URL : https://academic.oup.com/ije/article-pdf/26/suppl_1/S6/11434256/2600s6.pdf

E. Riboli, K. Hunt, N. Slimani, P. Ferrari, T. Norat et al., European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection, Public Health Nutrition, vol.59, issue.6b, pp.1113-1137, 2002.
DOI : 10.1093/ije/26.suppl_1.S1

URL : https://www.cambridge.org/core/services/aop-cambridge-core/content/view/54B10DAB1C70CE6A666E82122D2421D8/S1368980002001350a.pdf/div-class-title-european-prospective-investigation-into-cancer-and-nutrition-epic-study-populations-and-data-collection-div.pdf

M. Thornquist, G. Omenn, G. Goodman, J. Grizzle, L. Rosenstock et al., Statistical design and monitoring of the carotene and retinol efficacy trial (CARET), Controlled Clinical Trials, vol.14, issue.4, pp.308-332, 1993.
DOI : 10.1016/0197-2456(93)90228-6

G. Omenn, G. Goodman, M. Thornquist, J. Balmes, M. Cullen et al., Effects of a Combination of Beta Carotene and Vitamin A on Lung Cancer and Cardiovascular Disease, New England Journal of Medicine, vol.334, issue.18, pp.1150-1155, 1996.
DOI : 10.1056/NEJM199605023341802

R. Ross, J. Yuan, M. Yu, G. Wogan, G. Qian et al., Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma, The Lancet, vol.339, issue.8799, pp.943-949, 1992.
DOI : 10.1016/0140-6736(92)91528-G

J. Yuan, R. Ross, X. Wang, Y. Gao, and B. Henderson, Morbidity and Mortality in Relation to Cigarette Smoking in Shanghai, China, JAMA, vol.275, issue.21, pp.1646-50, 1996.
DOI : 10.1001/jama.1996.03530450036029

J. Hankin, D. Stram, K. Arakawa, S. Park, S. Low et al., Singapore Chinese Health Study: Development, Validation, and Calibration of the Quantitative Food Frequency Questionnaire, Nutrition and Cancer, vol.39, issue.2, pp.187-95, 2001.
DOI : 10.1207/S15327914nc392_5

J. Higgins, S. Thompson, J. Deeks, and D. Altman, Measuring inconsistency in meta-analyses, BMJ, vol.327, issue.7414, pp.557-60, 2003.
DOI : 10.1136/bmj.327.7414.557

L. Desquilbet and F. Mariotti, Dose-response analyses using restricted cubic spline functions in public health research, Statistics in Medicine, vol.50, issue.9, pp.1037-57, 2010.
DOI : 10.1002/sim.3841

K. Bhaskaran, I. Douglas, H. Forbes, I. Dos-santos-silva, D. Leon et al., Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5??24 million UK adults, The Lancet, vol.384, issue.9945, pp.755-65, 2014.
DOI : 10.1016/S0140-6736(14)60892-8

K. Kim, S. Jahan, E. Kabir, and R. Brown, A review of airborne polycyclic aromatic hydrocarbons (PAHs) and their human health effects, Environment International, vol.60, pp.71-80, 2013.
DOI : 10.1016/j.envint.2013.07.019

S. Hecht, Tobacco Smoke Carcinogens and Lung Cancer, JNCI Journal of the National Cancer Institute, vol.12, issue.5, pp.1194-210, 1999.
DOI : 10.1016/S0889-8588(05)70040-X

R. Godschalk, D. Feldker, P. Borm, E. Wouters, and F. Van-schooten, Body mass index modulates aromatic DNA adduct levels and their persistence in smokers. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, American Society of Preventive Oncology, vol.11, issue.8, pp.790-793, 2002.

A. Rundle, A. Madsen, M. Orjuela, L. Mooney, D. Tang et al., The association between benzo[a]pyrene-DNA adducts and body mass index, calorie intake and physical activity. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, pp.123-155, 2007.

T. Mizoue, S. Tokunaga, H. Kasai, K. Kawai, M. Sato et al., Body mass index and oxidative DNA damage: A longitudinal study, Cancer Science, vol.11, issue.8, pp.1254-1262, 2007.
DOI : 10.1016/0026-0495(91)90225-L

X. Li, Y. Bai, S. Wang, S. Nyamathira, X. Zhang et al., Association of Body Mass Index with Chromosome Damage Levels and Lung Cancer Risk among Males, Scientific Reports, vol.7, issue.1, p.9458, 2015.
DOI : 10.1016/0197-2456(86)90046-2

K. Dick, C. Nelson, L. Tsaprouni, J. Sandling, D. Aissi et al., DNA methylation and body-mass index: a genome-wide analysis, The Lancet, vol.383, issue.9933, pp.1990-1998, 2014.
DOI : 10.1016/S0140-6736(13)62674-4

S. Greer, J. Metcalf, Y. Wang, and M. Ohh, The updated biology of hypoxia-inducible factor, The EMBO Journal, vol.19, issue.11, pp.2448-60, 2012.
DOI : 10.1016/j.ccr.2011.02.014

A. Pasanen, M. Heikkila, K. Rautavuoma, M. Hirsila, K. Kivirikko et al., Hypoxia-inducible factor (HIF)-3?? is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2, The International Journal of Biochemistry & Cell Biology, vol.42, issue.7, pp.1189-200, 2010.
DOI : 10.1016/j.biocel.2010.04.008

M. Heikkila, A. Pasanen, K. Kivirikko, and J. Myllyharju, Roles of the human hypoxia-inducible factor (HIF)-3?? variants in the hypoxia response, Cellular and Molecular Life Sciences, vol.278, issue.23, pp.3885-901, 2011.
DOI : 10.1074/jbc.M209939200