P. Adams, P. Brissot, and L. Powell, EASL International Consensus Conference on Haemochromatosis, Journal of Hepatology, vol.33, issue.3, pp.485-504, 2000.
DOI : 10.1016/S0168-8278(01)80874-6

G. Anderson and G. Mclaren, Iron physiology and pathophysiology in humans, p.697, 2012.
DOI : 10.1007/978-1-60327-485-2

K. Bridle, D. Frazer, S. Wilkins, J. Dixon, D. Purdie et al., Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis, The Lancet, vol.361, issue.9358, pp.669-73, 2003.
DOI : 10.1016/S0140-6736(03)12602-5

E. Nemeth, M. Tuttle, J. Powelson, M. Vaughn, A. Donovan et al., Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization, Science, vol.306, issue.5704, pp.2090-2093, 2004.
DOI : 10.1126/science.1104742

A. Pietrangelo, Hemochromatosis: An endocrine liver disease, Hepatology, vol.128, issue.4, pp.1291-301, 2007.
DOI : 10.7326/0003-4819-138-8-200304150-00008
URL : http://onlinelibrary.wiley.com/doi/10.1002/hep.21886/pdf

J. Feder, A. Gnirke, W. Thomas, Z. Tsuchihashi, D. Ruddy et al., A novel MHC class I???like gene is mutated in patients with hereditary haemochromatosis, Nature Genetics, vol.88, issue.4, pp.399-408, 1996.
DOI : 10.1016/0888-7543(95)80219-C

B. Bacon and R. Britton, Clinical Penetrance of Hereditary Hemochromatosis, New England Journal of Medicine, vol.358, issue.3, pp.291-293, 2008.
DOI : 10.1056/NEJMe078215

E. Beutler, V. Felitti, J. Koziol, N. Ho, and T. Gelbart, Penetrance of 845G???A (C282Y) HFE hereditary haemochromatosis mutation in the USA, The Lancet, vol.359, issue.9302, pp.211-219, 2002.
DOI : 10.1016/S0140-6736(02)07447-0

A. Mccune and M. Worwood, Penetrance in hereditary hemochromatosis, Blood, vol.102, issue.7, p.2696, 2003.
DOI : 10.1182/blood-2003-05-1728

K. Allen, L. Gurrin, C. Constantine, N. Osborne, M. Delatycki et al., Hereditary Hemochromatosis, New England Journal of Medicine, vol.358, issue.3, pp.221-251, 2008.
DOI : 10.1056/NEJMoa073286

J. Rochette, L. Gac, G. Lassoued, K. Ferec, C. Robson et al., Factors influencing disease phenotype and penetrance in HFE haemochromatosis, Human Genetics, vol.41, issue.2, pp.233-281, 2010.
DOI : 10.7326/0003-4819-145-3-200608010-00009

Y. Deugnier, A. Jouanolle, J. Chaperon, R. Moirand, C. Pithois et al., Gender-specific phenotypic expression and screening strategies in C282Y-linked haemochromatosis: a study of 9396 French people, British Journal of Haematology, vol.41, issue.4, pp.1170-1178, 2002.
DOI : 10.1258/0007142991902628

R. Moirand, P. Adams, V. Bicheler, P. Brissot, and Y. Deugnier, Clinical Features of Genetic Hemochromatosis in Women Compared with Men, Annals of Internal Medicine, vol.127, issue.2, pp.105-115, 1997.
DOI : 10.7326/0003-4819-127-2-199707150-00002

B. Bacon, P. Adams, K. Kowdley, L. Powell, and A. Tavill, Diagnosis and management of hemochromatosis: 2011 Practice Guideline by the American Association for the Study of Liver Diseases, Hepatology, vol.23, issue.5 Suppl 1, pp.328-371, 2011.
DOI : 10.1155/2009/839308

E. Hanson, G. Imperatore, and W. Burke, HFE Gene and Hereditary Hemochromatosis: A HuGE Review, American Journal of Epidemiology, vol.154, issue.3, pp.193-206, 2001.
DOI : 10.1093/aje/154.3.193

M. Wood, L. Powell, and G. Ramm, Environmental and genetic modifiers of the progression to fibrosis and cirrhosis in hemochromatosis, Blood, vol.111, issue.9, pp.4456-62, 2008.
DOI : 10.1182/blood-2007-11-122374

N. Milman, Iron and pregnancy???a delicate balance, Annals of Hematology, vol.1, issue.9, pp.559-65, 2006.
DOI : 10.1136/bmj.310.6978.489

C. Latour, L. Kautz, C. Besson-fournier, M. Island, F. Canonne-hergaux et al., Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin, Hepatology, vol.281, issue.Spec No, pp.683-94, 2014.
DOI : 10.1074/jbc.M602098200

J. Neves, I. Olsson, G. Porto, and P. Rodrigues, ???/??? mouse are not reduced by multiple pregnancies, American Journal of Physiology-Gastrointestinal and Liver Physiology, vol.232, issue.4, pp.525-534, 2010.
DOI : 10.1006/prep.2000.1212
URL : http://ajpgi.physiology.org/content/ajpgi/298/4/G525.full.pdf

A. Jouanolle, P. Fergelot, M. Raoul, G. Gandon, M. Roussey et al., Prevalence of the C282Y mutation in Brittany: penetrance of genetic hemochromatosis?, Ann Genet, vol.41, pp.195-203, 1998.

P. Saliou, L. Gac, G. Mercier, A. Chanu, B. Gueguen et al., Evidence for the High Importance of Co-Morbid Factors in HFE C282Y/H63D Patients Cared by Phlebotomies: Results from an Observational Prospective Study, PLoS ONE, vol.94, issue.12, p.81128, 2013.
DOI : 10.1371/journal.pone.0081128.t003

D. Haskins, A. Stevens, . Jr, S. Finch, and C. Finch, IRON METABOLISM. IRON STORES IN MAN AS MEASURED BY PHLEBOTOMY 1, Journal of Clinical Investigation, vol.31, issue.6, pp.543-550, 1952.
DOI : 10.1172/JCI102639

L. Fletcher, J. Dixon, D. Purdie, L. Powell, and D. Crawford, Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis, Gastroenterology, vol.122, issue.2, pp.281-290, 2002.
DOI : 10.1053/gast.2002.30992

V. Scotet, M. Merour, A. Mercier, B. Chanu, L. Faou et al., Hereditary Hemochromatosis: Effect of Excessive Alcohol Consumption on Disease Expression in Patients Homozygous for the C282Y Mutation, American Journal of Epidemiology, vol.158, issue.2, pp.129-163, 2003.
DOI : 10.1093/aje/kwg123

P. Brissot, M. Bourel, D. Herry, J. Verger, M. Messner et al., Assessment of liver iron content in 271 patients: a reevaluation of direct and indirect methods, Gastroenterology, vol.80, pp.557-65, 1981.

Y. Deugnier, E. Bardou-jacquet, L. Lan, C. Brissot, and P. , Hyperferritin??mies non h??mochromatosiques, Gastroent??rologie Clinique et Biologique, vol.33, issue.4, pp.323-329, 2009.
DOI : 10.1016/j.gcb.2009.02.009

R. Blanco-rojo, L. Toxqui, A. Lopez-parra, C. Baeza-richer, A. Perez-granados et al., Influence of Diet, Menstruation and Genetic Factors on Iron Status: A Cross-Sectional Study in Spanish Women of Childbearing Age, International Journal of Molecular Sciences, vol.15, issue.12, pp.4077-87, 2014.
DOI : 10.1089/gtmb.2010.0140

R. Desgrippes, F. Laine, J. Morcet, M. Perrin, G. Manet et al., Decreased iron burden in overweight C282Y homozygous women: Putative role of increased hepcidin production, Hepatology, vol.281, issue.Suppl 1, pp.1784-92, 2013.
DOI : 10.1074/jbc.M513276200
URL : https://hal.archives-ouvertes.fr/inserm-00834268

F. Viteri, The consequences of iron deficiency and anaemia in pregnancy on maternal health, the foetus and the infant, SCN News, vol.11, pp.14-22, 1994.

W. Leong, Iron Nutrition, pp.81-99, 2012.
DOI : 10.1007/978-1-60327-485-2_5

C. Cao, O. Brien, and K. , Pregnancy and iron homeostasis: an update, Nutrition Reviews, vol.104, issue.2, pp.35-51, 2013.
DOI : 10.1097/00006250-200410000-00046

F. Who, Requirements of vitamin a, iron, folate and vitamin B12 In: FAO food and nutrition series, pp.246-78, 2004.

K. Millard, D. Frazer, S. Wilkins, and G. Anderson, Changes in the expression of intestinal iron transport and hepatic regulatory molecules explain the enhanced iron absorption associated with pregnancy in the rat, Gut, vol.53, issue.5, pp.655-60, 2004.
DOI : 10.1136/gut.2003.031153

L. Harvey, C. Armah, J. Dainty, R. Foxall, J. Lewis et al., Impact of menstrual blood loss and diet on iron deficiency among women in the UK, British Journal of Nutrition, vol.78, issue.04, pp.557-64, 2005.
DOI : 10.1016/S0015-0282(16)36070-8

M. Napolitano, A. Dolce, G. Celenza, E. Grandone, M. Perilli et al., Iron-dependent erythropoiesis in women with excessive menstrual blood losses and women with normal menses, Annals of Hematology, vol.45, issue.Suppl 8, pp.557-63, 2014.
DOI : 10.3109/00016346609158460

S. Dasharathy, S. Mumford, A. Pollack, N. Perkins, D. Mattison et al., Menstrual Bleeding Patterns Among Regularly Menstruating Women, American Journal of Epidemiology, vol.96, issue.1, pp.536-581, 2012.
DOI : 10.1210/jc.2010-1709
URL : https://academic.oup.com/aje/article-pdf/175/6/536/192373/kwr356.pdf

G. Nicolas, L. Viatte, D. Lou, M. Bennoun, C. Beaumont et al., Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis, Nature Genetics, vol.1, issue.1, pp.97-101, 2003.
DOI : 10.1074/jbc.M202653200

B. Andriopoulos, . Jr, E. Corradini, Y. Xia, S. Faasse et al., BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism, Nature Genetics, vol.41, issue.4, pp.482-489, 2009.
DOI : 10.1073/pnas.0409409102

J. Goodnough, E. Ramos, E. Nemeth, and T. Ganz, Inhibition of hepcidin transcription by growth factors, Hepatology, vol.99, issue.1, pp.291-300, 2012.
DOI : 10.1073/pnas.072632499