Regulation of CD4 and CD8 surface expression on human thymocyte subpopulations by triggering through CD2 and the CD3-T cell receptor, J Immunol, vol.142, pp.374-802783435, 1989. ,
Cytofluorometric Identification of Two Populations of Double Positive (CD4+,CD8+) T Lymphocytes in Human Peripheral Blood, Biochemical and Biophysical Research Communications, vol.191, issue.2, pp.601-91260, 1993. ,
DOI : 10.1006/bbrc.1993.1260
Coexpression of T4 and T8 on peripheral blood T cells demonstrated by two-color fluorescence flow cytometry, J Immunol, vol.134, pp.2281-62982943, 1985. ,
Peripheral CD4+CD8+ T cells are differentiated effector memory cells with antiviral functions, Blood, vol.104, issue.2, pp.478-86, 2004. ,
DOI : 10.1182/blood-2003-12-4395
URL : http://www.bloodjournal.org/content/bloodjournal/104/2/478.full.pdf
CD4+ CD8+ double positive (DP) T cells in health and disease, Autoimmunity Reviews, vol.3, issue.3, pp.215-235, 2004. ,
DOI : 10.1016/j.autrev.2003.09.001
Multiple populations of T lymphocytes are distinguished by the level of CD4 and CD8 coexpression and require individual consideration, Journal of Leukocyte Biology, vol.82, issue.1, pp.4-6, 2006. ,
DOI : 10.1111/j.0818-9641.2004.01253.x
Premature escape of double-positive thymocytes to the periphery of young mice. Possible role in autoimmunity, J Immunol, vol.152, pp.1509-148120365, 1994. ,
Rat Peripheral CD4+CD8+ T Lymphocytes Are Partially Immunocompetent Thymus-Derived Cells That Undergo Post-Thymic Maturation to Become Functionally Mature CD4+ T Lymphocytes, The Journal of Immunology, vol.168, issue.10, pp.5005-5018, 2002. ,
DOI : 10.4049/jimmunol.168.10.5005
URL : http://www.jimmunol.org/content/jimmunol/168/10/5005.full.pdf
Interleukin-4 mediates CD8 induction on human CD4C T-cell clones, Nature, 1988. ,
DOI : 10.1038/335642a0
URL : http://www.nature.com/nature/journal/v335/n6191/pdf/335642a0.pdf
Upregulation of CD4 on CD8+ T cells: CD4dimCD8bright T cells constitute an activated phenotype of CD8+ T cells, Immunology, vol.11, issue.3, pp.270-80, 2001. ,
DOI : 10.1016/S0022-2143(98)90090-7
Increased CD4C/ CD8C double-positive T cells in chronic Chagasic patients, PLoS Negl Trop Dis, vol.5, 1294. ,
DOI : 10.1371/journal.pntd.0001294
URL : https://doi.org/10.1371/journal.pntd.0001294
Distinct CD4C CD8C double-positive T cells in the blood and liver of patients during chronic hepatitis B and C, PLoS One, vol.6, 2011. ,
T Lymphocytes that Express Cytotoxicity???Associated Molecules and Are Committed to Produce Interferon????? and Tumor Necrosis Factor?????, The Journal of Infectious Diseases, vol.178, issue.4, pp.1158-629806050, 1998. ,
DOI : 10.1086/515674
URL : https://academic.oup.com/jid/article-pdf/178/4/1158/2494074/178-4-1158.pdf
Potent HIV-specific responses are enriched in a unique subset of CD8+ T cells that coexpresses CD4 on its surface, Blood, vol.114, issue.18, pp.3841-53, 2009. ,
DOI : 10.1182/blood-2009-02-202481
Presence of CD4+CD8+ double-positive T cells with very high interleukin-4 production potential in lesional skin of patients with systemic sclerosis, Arthritis & Rheumatism, vol.46, issue.10, pp.3459-67, 2007. ,
DOI : 10.4049/jimmunol.168.7.3649
Peripheral CD4CD8 Double Positive T Cells with a Distinct Helper Cytokine Profile Are Increased in Rheumatoid Arthritis, PLoS ONE, vol.25, issue.5, 2014. ,
DOI : 10.1371/journal.pone.0093293.g006
double-positive T cells in blood, cerebrospinal fluid and multiple sclerosis lesions, Clinical & Experimental Immunology, vol.87, issue.2, pp.404-415, 2014. ,
DOI : 10.1128/JVI.00131-13
URL : http://onlinelibrary.wiley.com/doi/10.1111/cei.12345/pdf
CD4+CD8+ human small intestinal T cells are decreased in coeliac patients, with CD8 expression downregulated on intra-epithelial T cells in the active disease, European Journal of Gastroenterology & Hepatology, vol.16, issue.10, pp.961-969, 2004. ,
DOI : 10.1097/00042737-200410000-00003
CD4CD8alphaalpha lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease, PLoS Biol, vol.12, 2014. ,
Coexpression of CD4 and CD8 on peripheral blood T cells and lamina propria T cells in inflammatory bowel disease by two colour immunofluorescence and flow cytometric analysis., Gut, vol.32, issue.8, pp.918-940, 1991. ,
DOI : 10.1136/gut.32.8.918
Isolation of tumor-specific cytotoxic CD4C and CD4CCD8dimC T-cell clones infiltrating a cutaneous T-cell lymphoma, Blood, vol.91, pp.4331-419596682, 1998. ,
Increased frequency of nonconventional double positive CD4CD8 ???? T cells in human breast pleural effusions, International Journal of Cancer, vol.179, issue.2, pp.374-80, 2009. ,
DOI : 10.4049/jimmunol.179.6.3452
Double positive CD4CD8 alphabeta T cells: a new tumor-reactive population in human melanomas, PLoS One, vol.5, 2010. ,
A Double-Positive CD4+CD8+ T-Cell Population Is Commonly Found in Nodular Lymphocyte Predominant Hodgkin Lymphoma, American Journal of Clinical Pathology, vol.126, issue.5, pp.805-819, 2006. ,
DOI : 10.1309/Y8KD32QGRYFN1XQX
Tumor-reactive CD4+CD8????+ CD103+ ????T cells: A prevalent tumor-reactive T-cell subset in metastatic colorectal cancers, International Journal of Cancer, vol.4, issue.suppl 1, pp.2923-2955, 2011. ,
DOI : 10.1038/nri1309
double-positive T cells: more than just a developmental stage?, Journal of Leukocyte Biology, vol.53, issue.1, pp.31-81, 2015. ,
DOI : 10.1007/s00262-003-0445-0
URL : http://www.jleukbio.org/content/97/1/31.full.pdf
double-positive T??cells, European Journal of Immunology, vol.6, issue.7, pp.1770-82, 2016. ,
DOI : 10.1517/14712598.2010.480971
URL : https://hal.archives-ouvertes.fr/inserm-01319366
CD40-CD40 ligand, Journal of Leukocyte Biology, vol.67, issue.1, pp.2-1710647992, 2000. ,
DOI : 10.1002/jlb.67.1.2
CD40L expression permits CD8+ T cells to execute immunologic helper functions, Blood, vol.122, issue.3, pp.405-417, 2013. ,
DOI : 10.1182/blood-2013-02-483586
URL : http://www.bloodjournal.org/content/bloodjournal/122/3/405.full.pdf
CD40 ligand-positive CD8+ T cell clones allow B cell growth and differentiation, European Journal of Immunology, vol.180, issue.10, pp.2972-77589100, 1995. ,
DOI : 10.1146/annurev.iy.11.040193.001555
Activated human T cells express a ligand for the human B cell-associated antigen CD40 which participates in T cell-dependent activation of B lymphocytes, European Journal of Immunology, vol.9, issue.10, pp.2573-2581, 1992. ,
DOI : 10.1002/eji.1830221016
Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells, The Journal of Experimental Medicine, vol.154, issue.9, pp.1679-89, 1998. ,
DOI : 10.1038/ng0193-88
Signalling through TEC kinases regulates conventional versus innate CD8+ T-cell development, Nature Reviews Immunology, vol.8, issue.6, pp.479-85, 2007. ,
DOI : 10.4049/jimmunol.170.12.6090
CD4 CTL: Living up to the challenge, Seminars in Immunology, vol.25, issue.4, pp.273-81, 2013. ,
DOI : 10.1016/j.smim.2013.10.022
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886800/pdf
A Role for CD40 Expression on CD8+ T Cells in the Generation of CD8+ T Cell Memory, Science, vol.297, issue.5589, pp.2060-2063, 2002. ,
DOI : 10.1126/science.1072615
The CD40/CD154 receptor/ligand dyad, Cell Mol Life Sci, vol.58, pp.4-43, 2001. ,
Toll-like receptor stimulation as a third signal required for activation of human naive B cells, European Journal of Immunology, vol.20, issue.4, pp.810-816, 2006. ,
DOI : 10.4049/jimmunol.170.2.686
IL-2 Requirement for Human Plasma Cell Generation: Coupling Differentiation and Proliferation by Enhancing MAPK-ERK Signaling, The Journal of Immunology, vol.189, issue.1, pp.161-73, 2012. ,
DOI : 10.4049/jimmunol.1200301
URL : https://hal.archives-ouvertes.fr/inserm-00869090
Human interleukin-2 promotes proliferation of activated B cells via surface receptors similar to those of activated T cells, Nature, vol.227, issue.5995, pp.641-36438535, 1984. ,
DOI : 10.1038/312641a0
Identification of a T cell-derived b cell growth factor distinct from interleukin 2, Journal of Experimental Medicine, vol.155, issue.3, pp.914-236977612, 1982. ,
DOI : 10.1084/jem.155.3.914
Memory, but not naive, peripheral blood B lymphocytes differentiate into Ig-secreting cells after CD40 ligation and costimulation with IL-4 and the differentiation factors IL-2, IL- 10, and IL-3, J Immunol, vol.159, pp.2085-909278293, 1997. ,
Generation of memory B cells and plasma cells in vitro, Science, vol.1, issue.5, pp.720-27537388, 1995. ,
DOI : 10.1016/1074-7613(94)90073-6
IL-10 interrupts memory B cell expansion in the germinal center by inducing differentiation into plasma cells, 02%3c508::AID-IMMU508%3e3.0.CO, pp.508-151521, 1998. ,
DOI : 10.1002/art.1780381210
IL-13 induces proliferation and differentiation of human B cells activated by the CD40 ligand, International Immunology, vol.5, issue.6, pp.657-637688562, 1993. ,
DOI : 10.1093/intimm/5.6.657
Kinetics of Human B Cell Behavior and Amplification of Proliferative Responses following Stimulation with IL-21, The Journal of Immunology, vol.177, issue.8, pp.5236-5283, 2006. ,
DOI : 10.4049/jimmunol.177.8.5236
Essential Role of IL-21 in B Cell Activation, Expansion, and Plasma Cell Generation during CD4+ T Cell-B Cell Collaboration, The Journal of Immunology, vol.179, issue.9, pp.5886-96, 2007. ,
DOI : 10.4049/jimmunol.179.9.5886
Origin and Function of Circulating Plasmablasts during Acute Viral Infections PMID:22566959, Front Immunol, vol.3, p.78, 2012. ,
Positive and negative functions of B lymphocytes in tumors PMID:27331871, Oncotarget, vol.http, 2016. ,
IgG4 subclass antibodies impair antitumor immunity in melanoma, Journal of Clinical Investigation, vol.123, issue.4, pp.1457-74, 2013. ,
DOI : 10.1172/JCI65579DS1
URL : http://www.jci.org/articles/view/65579/files/pdf
Elevated IgG4 in patient circulation is associated with the risk of disease progression in melanoma, OncoImmunology, vol.7, issue.11, 2015. ,
DOI : 10.4161/mabs.27029
Anti- CD40 monoclonal antibodies or CD4C T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signaling pathways, J Immunol, vol.147, pp.8-131711085, 1991. ,
Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells., Proceedings of the National Academy of Sciences, vol.90, issue.8, pp.3730-3734, 1993. ,
DOI : 10.1073/pnas.90.8.3730
URL : http://www.pnas.org/content/90/8/3730.full.pdf
B cell regulation of the anti-tumor response and role in carcinogenesis, Journal for ImmunoTherapy of Cancer, vol.18, issue.12, p.4027437104, 2016. ,
DOI : 10.1158/1078-0432.CCR-12-0234
Human T cells induce their own regulation through activation of B cells, Journal of Autoimmunity, vol.36, issue.3-4, pp.228-266, 2011. ,
DOI : 10.1016/j.jaut.2011.01.005
URL : https://hal.archives-ouvertes.fr/hal-00771265
T Follicular Helper Cell Differentiation, Function, and Roles in Disease, Immunity, vol.41, issue.4, pp.529-571, 2014. ,
DOI : 10.1016/j.immuni.2014.10.004
URL : https://doi.org/10.1016/j.immuni.2014.10.004
T Cell-Dependent Activation of Dendritic Cells Requires IL-12 and IFN-?? Signaling in T Cells, The Journal of Immunology, vol.177, issue.6, pp.3625-3659, 2006. ,
DOI : 10.4049/jimmunol.177.6.3625
Human dendritic cells sequentially matured with CD4+ T cells as a secondary signal favor CTL and long-term T memory cell responses, Biological Research, vol.45, issue.1, pp.33-43, 2012. ,
DOI : 10.4067/S0716-97602012000100005
DC for IL-12p70 production, European Journal of Immunology, vol.194, issue.8, pp.2251-62, 2008. ,
DOI : 10.4049/jimmunol.177.4.2131
URL : http://onlinelibrary.wiley.com/doi/10.1002/eji.200838199/pdf
CD40-CD40 Ligand Interaction between Dendritic Cells and CD8+ T Cells Is Needed to Stimulate Maximal T Cell Responses in the Absence of CD4+ T Cell Help, The Journal of Immunology, vol.178, issue.5, pp.2844-52, 2007. ,
DOI : 10.4049/jimmunol.178.5.2844
Helper cell-independent antitumor activity of potent CD8C T cell epitope peptide vaccines is dependent upon CD40L, Oncoimmunology, vol.2, 2013. ,
T cells, European Journal of Immunology, vol.11, issue.6, pp.1511-1518, 2013. ,
DOI : 10.1038/nm1292
CD20+ B Cells: The Other Tumor-Infiltrating Lymphocytes, The Journal of Immunology, vol.185, issue.9, pp.4977-82, 2010. ,
DOI : 10.4049/jimmunol.1001323
URL : http://www.jimmunol.org/content/jimmunol/185/9/4977.full.pdf
Long-Term Survival for Patients With Non???Small-Cell Lung Cancer With Intratumoral Lymphoid Structures, Journal of Clinical Oncology, vol.26, issue.27, pp.4410-4417, 2008. ,
DOI : 10.1200/JCO.2007.15.0284
Systematic analysis of immune infiltrates in highgrade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors, PLoS One, vol.4, 2009. ,
A comparative study of the cellular immune response in patients with stage IB cervical squamous cell carcinoma. Low numbers of several immune cell subtypes are strongly associated with relapse of disease within 5??years, Gynecologic Oncology, vol.108, issue.1, pp.106-117, 2008. ,
DOI : 10.1016/j.ygyno.2007.08.089
High avidity melanoma-reactive cytotoxic T lymphocytes are efficiently induced from peripheral blood lymphocytes on stimulation by peptide-pulsed melanoma cells, Clin Cancer Res, vol.6, pp.1459-6710778978, 2000. ,
HLA Anchor Optimization of the Melan-A-HLA-A2 Epitope within a Long Peptide Is Required for Efficient Cross-Priming of Human Tumor-Reactive T Cells, The Journal of Immunology, vol.188, issue.5, pp.2102-2112, 2012. ,
DOI : 10.4049/jimmunol.1101807
PBMC are as good a source of tumor-reactive T lymphocytes as TIL after selection by Melan-A/A2 multimer immunomagnetic sorting, Cancer Immunology, Immunotherapy, vol.162, issue.2, pp.185-95, 2008. ,
DOI : 10.4049/jimmunol.175.7.4797
URL : https://hal.archives-ouvertes.fr/inserm-00167752