MicroRNA-based Drugs for Brain Tumours

Abstract : MicroRNAs (miRNAs) are key regulatory elements coded by the genome. A single miRNA can downregulate expression of multiple genes involved in diverse functions. As cancer is a disease with multiple gene aberrations, developing novel approaches to identify and modulate miRNA-pathways may result in a breakthrough for cancer treatment. With a special focus on glioblastoma, this review provides an up-to-date understanding of miRNA biogenesis, role of miRNA in cancer resistance, essential tools for modulating miRNA expression, emerging list of clinically promising RNAi delivery systems and how they can be adapted for therapy.
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Shubaash Anthiya, Audrey Griveau, Claire Loussouarn, Patrick Baril, Martin Garnett, et al.. MicroRNA-based Drugs for Brain Tumours. Trends in Cancer, Cell Press, 2018, 4 (3), pp.222-238. ⟨10.1016/j.trecan.2017.12.008⟩. ⟨inserm-01691531⟩

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