Context. – In 2012, the French Infectious Diseases Society (French acronym SPILF) initiated the “Coordination of epidemic and biological risk”(SPILF-COREB - Emergences [SCE]) group to support the readiness and response of healthcare workers (HCWs) to new alerts.Objective. – To present the SCE group, its functioning, and the main support it provided for frontline HCWs.Methods. – A multidisciplinary group of heads of infectious disease departments from reference hospitals was created to build a network ofclinical expertise for care, training, and research in the field of epidemic and biological risk (EBR). The network developed a set of standardizedoperational procedures (SOPs) to guide interventions to manage EBR-suspect patients.Results. – A working group created the SOP aimed at frontline HCWs taking care of patients. Priority was given to the development of a genericprocedure, which was then adapted according to the current alert. Five key steps were identified and hierarchized: detecting, protecting, caringfor, alerting, and referring the EBR patient. The interaction between clinicians and those responsible for the protection of the community wascrucial. The SOPs validated by the SPILF and its affiliates were disseminated to a wide range of key stakeholders through various media includingworkshops and the SPILF’s website.