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Journal articles
E2F1 interacts with BCL‐xL and regulates its subcellular localization dynamics to trigger cell death
Abstract : E2F1 is the main pro-apoptotic effector of the pRB-regulated tumor suppressor pathway by promoting the transcription of various pro-apoptotic proteins. We report here that E2F1 partly localizes to mitochondria, where it favors mitochondrial outer membrane permeabilization. E2F1 interacts with BCL-xL independently from its BH3 binding interface and induces a stabilization of BCL-xL at mitochondrial membranes. This prevents efficient control of BCL-xL over its binding partners, in particular over BAK resulting in the induction of cell death. We thus identify a new, non-BH3-binding regulator of BCL-xL localization dynamics that influences its anti-apoptotic activity.
Cited literature [32 references]
https://www.hal.inserm.fr/inserm-01669957
Contributor : Elizabeth Bernardo <>
Submitted on : Thursday, December 21, 2017 - 9:08:26 AM
Last modification on : Friday, June 19, 2020 - 1:42:02 AM
Contributor : Elizabeth Bernardo <>
Submitted on : Thursday, December 21, 2017 - 9:08:26 AM
Last modification on : Friday, June 19, 2020 - 1:42:02 AM
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2017-Vuillier_et_al-2017-EMBO_...
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