Skip to Main content Skip to Navigation
Journal articles

Atypical, non-standard functions of the microtubule associated Tau protein

Abstract : AbstractSince the discovery of the microtubule-associated protein Tau (MAPT) over 40 years ago, most studies have focused on Tau’s role in microtubule stability and regulation, as well as on the neuropathological consequences of Tau hyperphosphorylation and aggregation in Alzheimer’s disease (AD) brains. In recent years, however, research efforts identified new interaction partners and different sub-cellular localizations for Tau suggesting additional roles beyond its standard function as microtubule regulating protein. Moreover, despite the increasing research focus on AD over the last decades, Tau was only recently considered as a promising therapeutic target for the treatment and prevention of AD as well as for neurological pathologies beyond AD e.g. epilepsy, excitotoxicity, and environmental stress. This review will focus on atypical, non-standard roles of Tau on neuronal function and dysfunction in AD and other neurological pathologies providing novel insights about neuroplastic and neuropathological implications of Tau in both the central and the peripheral nervous system.
Document type :
Journal articles
Complete list of metadatas

Cited literature [154 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01654098
Contributor : Bmc Bmc <>
Submitted on : Sunday, December 3, 2017 - 5:24:09 AM
Last modification on : Thursday, January 16, 2020 - 10:20:07 AM
Document(s) archivé(s) le : Sunday, March 4, 2018 - 12:37:38 PM

File

40478_2017_Article_489.pdf
Publication funded by an institution

Identifiers

Collections

Citation

Ioannis Sotiropoulos, Marie-Christine Galas, Joana M. Silva, Efthimios Skoulakis, Susanne Wegmann, et al.. Atypical, non-standard functions of the microtubule associated Tau protein. Acta Neuropathologica Communications, BioMed Central part of Springer Science, 2016, 5 (1), pp.91. ⟨10.1186/s40478-017-0489-6⟩. ⟨inserm-01654098⟩

Share

Metrics

Record views

414

Files downloads

282