Biology of bone sarcomas and new therapeutic developments

Abstract : Bone sarcomas are tumours belonging to the family of mesenchymal tumours and constitute a highly heterogeneous tumour group. The three main bone sarcomas are: osteosarcoma, Ewing sarcoma and chondrosarcoma each subdivided in diverse histological entities. They are clinically characterised by a relatively high morbidity and mortality, especially in children and adolescents. Although these tumours are histologically, molecularly and genetically heterogeneous, they share a common involvement of the local microenvironment in their pathogenesis. This review gives a brief overview of their specificities and summarises the main therapeutic advances in the field of bone sarcoma.
Liste complète des métadonnées

Littérature citée [106 références]  Voir  Masquer  Télécharger
Contributeur : Dominique Heymann <>
Soumis le : vendredi 1 décembre 2017 - 15:59:07
Dernière modification le : jeudi 5 avril 2018 - 10:37:03


  • HAL Id : inserm-01653600, version 1



Hannah Brown, Kristina Schiavone, François Gouin, Marie-Françoise Heymann, Dominique Heymann. Biology of bone sarcomas and new therapeutic developments . Calcified Tissue International, Springer Verlag, In press. 〈inserm-01653600〉



Consultations de la notice


Téléchargements de fichiers