Abstract : Bone sarcomas are tumours belonging to the family of mesenchymal tumours and constitute a highly heterogeneous tumour group. The three main bone sarcomas are: osteosarcoma, Ewing sarcoma and chondrosarcoma each subdivided in diverse histological entities. They are clinically characterised by a relatively high morbidity and mortality, especially in children and adolescents. Although these tumours are histologically, molecularly and genetically heterogeneous, they share a common involvement of the local microenvironment in their pathogenesis. This review gives a brief overview of their specificities and summarises the main therapeutic advances in the field of bone sarcoma.
http://www.hal.inserm.fr/inserm-01653600
Contributeur : Dominique Heymann
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Soumis le : vendredi 1 décembre 2017 - 15:59:07
Dernière modification le : jeudi 5 avril 2018 - 10:37:03
Hannah Brown, Kristina Schiavone, François Gouin, Marie-Françoise Heymann, Dominique Heymann. Biology of bone sarcomas and new therapeutic developments . Calcified Tissue International, Springer Verlag, In press. 〈inserm-01653600〉
