ORTHOPAEDIC IMPLANT FAILURE Aseptic implant loosening: contributions and future challenges of mouse models in translational research

Luis Alberto Córdova 1, 2 Verena Stresing 2 Bérengère Gobin 2 Philippe Rosset 2, 3, 4 Norbert Passuti 2, 5 François Gouin 2, 5 Valérie Trichet 2 Pierre Layrolle 2 Dominique Heymann 6, 2, 5
1 Department of Oral and Maxillofacial Surgery [Santiago, Chile]
2 Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives
3 Université de Tours
4 CHU Tours
5 CHU Nantes - Centre hospitalier universitaire de Nantes
6 Department of Oncology and Metabolism [Sheffield, UK]
Abstract : Aseptic loosening as a result of wear debris is considered to be the main cause of long-term implant failure in orthopaedic surgery and improved biomaterials for bearing surfaces decreases significantly the release of micrometric wear particles. Increasingly, in-depth knowledge of osteoimmunology highlights the role of nanoparticles and ions released from some of these new bearing couples, opening up a new era in the comprehension of aseptic loosening. Mouse models have been essential in the progress made in the early comprehension of pathophysiology and in testing new therapeutic agents for particle-induced osteolysis. However, despite this encouraging progress, there is still no valid clinical alternative to revision surgery. The present review provides an update of the most commonly used bearing couples, the current concepts regarding particle-cell interactions and the approaches used to study the biology of periprosthetic osteolysis. It also discusses the contribution and future challenges of mouse models for successful translation of the preclinical progress into clinical applications.
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Article dans une revue
Acta Biomaterialia, Elsevier, 2015, 13, pp.150 - 158. 〈10.1042/CS20130338〉
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Soumis le : mercredi 22 novembre 2017 - 15:43:46
Dernière modification le : jeudi 5 avril 2018 - 10:36:48

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Luis Alberto Córdova, Verena Stresing, Bérengère Gobin, Philippe Rosset, Norbert Passuti, et al.. ORTHOPAEDIC IMPLANT FAILURE Aseptic implant loosening: contributions and future challenges of mouse models in translational research. Acta Biomaterialia, Elsevier, 2015, 13, pp.150 - 158. 〈10.1042/CS20130338〉. 〈inserm-01644792〉

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