PD-1 immunor- 630 eceptor inhibits B cell receptor-mediated signaling by recruiting src homol- 631 ogy 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine, p.632 ,
DOI : 10.1073/pnas.231486598
URL : http://www.pnas.org/content/98/24/13866.full.pdf
PD-1 634 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta 635 signalosome and downstream signaling to PKCtheta, FEBS Lett, vol.636574, pp.37-41, 2004. ,
Programmed death-1 upregulation is correlated with dysfunction of tumor-infiltrating CD8+ T lymphocytes in human non-small cell lung cancer, Cellular and Molecular Immunology, vol.173, issue.5, pp.389-95, 2010. ,
DOI : 10.1128/JVI.77.8.4911-4927.2003
PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors, Journal of Clinical Investigation, vol.124, issue.5, pp.2246-59, 2014. ,
DOI : 10.1172/JCI73639DS1
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001555/pdf
Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients, Nature Medicine, vol.22, issue.4, pp.433-441, 2016. ,
DOI : 10.4049/jimmunol.1103020
CTLA-4 and PD-1/PD-L1 Blockade: New Immunotherapeutic Modalities with Durable Clinical Benefit in Melanoma Patients, Clinical Cancer Research, vol.19, issue.19, pp.5300-5309, 2013. ,
DOI : 10.1158/1078-0432.CCR-13-0143
URL : http://clincancerres.aacrjournals.org/content/clincanres/19/19/5300.full.pdf
Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens, Nature, vol.102, issue.7528, pp.577-81, 2014. ,
DOI : 10.1073/pnas.0506580102
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279952/pdf
PD-1 684 blockade in tumors with mismatch-repair deficiency, N Engl J Med, vol.685372, pp.2509-2529, 2015. ,
High-throughput epitope discovery reveals frequent recognition 691 of neo-antigens by CD4þ T cells in human melanoma Cancer genome landscapes, Nat Med Science, vol.69021339, issue.692, pp.81-86, 2013. ,
Chronic Virus Infection Enforces Demethylation of the Locus that Encodes PD-1 in Antigen-Specific CD8+ T Cells, Immunity, vol.35, issue.3, pp.400-412, 2011. ,
DOI : 10.1016/j.immuni.2011.06.015
Cutting Edge: Prolonged Exposure to HIV Reinforces a Poised Epigenetic Program for PD-1 Expression in Virus-Specific CD8 T Cells, The Journal of Immunology, vol.191, issue.2, pp.540-544, 2013. ,
DOI : 10.4049/jimmunol.1203161
ABSTRACT, Journal of Virology, vol.90, issue.19, pp.8934-8980, 2016. ,
DOI : 10.1128/JVI.00798-16
MART-1-specific CD8 T cells: from thymus to tumor. Trends 707, Immunol, vol.23, pp.325-333, 2002. ,
Functional T cells targeting NY-ESO-1 or Melan-A are 713 predictive for survival of patients with distant melanoma metastasis, J Clin Oncol, vol.71430, pp.1835-1876, 2012. ,
Knol 716 AC, et al. Treatment of metastatic melanoma with autologous Melan-A/ 717 MART-1-specific cytotoxic T lymphocyte clones, J Invest Dermatol, vol.718129, pp.2835-2877, 2009. ,
Adoptive transfer of tumor-reactive Melan-A-specific CTL clones in 721 melanoma patients is followed by increased frequencies of additional 722 ,
PD-1 expression conditions T cell avidity within an antigen-specific repertoire, OncoImmunology, vol.6, issue.1, pp.1104448-726, 2016. ,
DOI : 10.1097/CJI.0b013e3181fad2b0
URL : https://hal.archives-ouvertes.fr/inserm-01280886
A full 727 GMP process to select and amplify epitope-specific T lymphocytes for 728 adoptive immunotherapy of metastatic melanoma 731 Improved endpoints for cancer immunotherapy trials, Clin Dev Immunol J Natl Cancer Inst, vol.7292013102, issue.732, pp.1388-97, 2010. ,
734 et al. Efficient detection and immunomagnetic sorting of specific T cells 735 using multimers of MHC class I and peptide with reduced CD8 binding, p.736 ,
738 et al. A fast and efficient HLA multimer-based sorting procedure 740 that induces little apoptosis to isolate clinical grade human tumor 741 specific T lymphocytes, Cancer Immunol Immunother, vol.58, pp.742-553, 2009. ,
TIGIT and PD-1 impair tumor antigen???specific CD8+ T cells in melanoma patients, Journal of Clinical Investigation, vol.125, issue.5, pp.2046-58, 2015. ,
DOI : 10.1172/JCI80445DS1
URL : http://www.jci.org/articles/view/80445/files/pdf
CD137 Accurately Identifies and Enriches for Naturally Occurring Tumor-Reactive T Cells in Tumor, Clinical Cancer Research, vol.20, issue.1, pp.44-55, 2014. ,
DOI : 10.1158/1078-0432.CCR-13-0945
URL : http://clincancerres.aacrjournals.org/content/clincanres/20/1/44.full.pdf
Anti-CTLA-4 therapy broadens the melanoma-reactive 764 ,
Neoantigens in cancer immunotherapy, Science, vol.43, issue.D1, p.769 ,
DOI : 10.1093/nar/gku1075
T-cell invigoration to tumour burden ratio associated with anti-PD-1 response, Nature, vol.29, issue.7652, pp.60-65, 2017. ,
DOI : 10.1038/nbt.1991
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554367/pdf
The response of autologous T cells to a human melanoma is dominated by mutated neoantigens, Proceedings of the National Academy of Sciences, vol.36, issue.4, pp.16013-16021, 2005. ,
DOI : 10.2174/1566524013363447