Abstract : INTRODUCTION:
The living environment affects general health and may influence cognitive aging; however, the relationships between neighborhood characteristics and dementia are still poorly understood.
METHODS:
We used data from a French population-based prospective study (the Three-City cohort) that included 7016 participants aged 65 years and older with a 12-year follow-up. We used principal components analysis of neighborhood composition indicators to construct the Three-City deprivation score. To study its impact on dementia incidence, we performed survival analyses using a marginal Cox model to take into account intraneighborhood correlations. As interaction with sex was significant, analyses were stratified by sex.
RESULTS:
Even after controlling on individual factors, women living in deprived neighborhoods were at higher risk of dementia (hazard ratio = 1.29, 95% confidence interval 1.00-1.67) and Alzheimer's disease (hazard ratio = 1.42, 95% confidence interval 1.09-1.84). No association was found for men.
DISCUSSION:
Living in a deprived neighborhood is associated with higher risk of dementia in women.
https://www.hal.inserm.fr/inserm-01635833
Contributeur : Claudine Berr
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Soumis le : mercredi 15 novembre 2017 - 17:28:59
Dernière modification le : jeudi 7 février 2019 - 17:54:50
Document(s) archivé(s) le : vendredi 16 février 2018 - 16:03:27
Noémie Letellier, Laure-Anne Gutierrez, Isabelle Carrière, Audrey Gabelle, Jean-François Dartigues, et al.. Sex-specific association between neighborhood characteristics and dementia: the Three-City cohort. Alzheimer's and Dementia, Elsevier, 2017, Epub ahead of print. 〈10.1016/j.jalz.2017.09.015〉. 〈inserm-01635833〉
