Sex-specific association between neighborhood characteristics and dementia: the Three-City cohort

Abstract : INTRODUCTION: The living environment affects general health and may influence cognitive aging; however, the relationships between neighborhood characteristics and dementia are still poorly understood. METHODS: We used data from a French population-based prospective study (the Three-City cohort) that included 7016 participants aged 65 years and older with a 12-year follow-up. We used principal components analysis of neighborhood composition indicators to construct the Three-City deprivation score. To study its impact on dementia incidence, we performed survival analyses using a marginal Cox model to take into account intraneighborhood correlations. As interaction with sex was significant, analyses were stratified by sex. RESULTS: Even after controlling on individual factors, women living in deprived neighborhoods were at higher risk of dementia (hazard ratio = 1.29, 95% confidence interval 1.00-1.67) and Alzheimer's disease (hazard ratio = 1.42, 95% confidence interval 1.09-1.84). No association was found for men. DISCUSSION: Living in a deprived neighborhood is associated with higher risk of dementia in women.
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Noémie Letellier, Laure-Anne Gutierrez, Isabelle Carrière, Audrey Gabelle, Jean-François Dartigues, et al.. Sex-specific association between neighborhood characteristics and dementia: the Three-City cohort. Alzheimer's and Dementia, Elsevier, 2017, Epub ahead of print. ⟨10.1016/j.jalz.2017.09.015⟩. ⟨inserm-01635833⟩

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