Prognostic value of FDG-PET indices for the assessment of histological response to neoadjuvant chemotherapy and outcome in pediatric patients with Ewing sarcoma and osteosarcoma

Clément Bailly 1, 2 Rodolphe Leforestier 2 Loïc Campion 3 Estelle Thébaud 4 Anne Moreau 5 Françoise Kraeber-Bodéré 1, 2 Thomas Carlier 1, 2 Caroline Bodet-Milin 1, 2, *
* Auteur correspondant
1 CRCNA - Centre de Recherche en Cancérologie / Nantes - Angers
2 NANTES - Médecine Nucléaire - Département de Médecine Nucléaire
3 Département de Biométrie [Saint Herblain]
4 Département d'Oncologie Pédiatrique [CHU Nantes]
5 Département de Pathologie [CHU Nantes]
Abstract : Purpose The objective of this retrospective work was to evaluate the prognostic value on histological response and survival of quantitative indices derived from FDG-PET performed before and after chemotherapy (CHT), in a homogeneous pediatric Ewing sarcoma (EWS) and Osteo-sarcoma (OST) population. Methods Thirty-one patients with EWS and 31 with OST were included. All patients were treated with neoadjuvant CHT, and underwent surgery for local control. All patients had FDG-PET at diagnosis and after CHT, prior to surgery. Several parameters were evaluated: SUVmax, SUVpeak, SUVmean, metabolic tumor volume, total lesion glycolysis, 7 textural features and 3 shape features (SF). The segmentation was performed using an adaptive approach. Results were compared to histopathological regression of the resected tumor and to clinical follow-up for survival evaluation.
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Article dans une revue
PLoS ONE, Public Library of Science, 2017, 12 (8), pp.e0183841. 〈10.1371/journal.pone.0183841〉
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Clément Bailly, Rodolphe Leforestier, Loïc Campion, Estelle Thébaud, Anne Moreau, et al.. Prognostic value of FDG-PET indices for the assessment of histological response to neoadjuvant chemotherapy and outcome in pediatric patients with Ewing sarcoma and osteosarcoma. PLoS ONE, Public Library of Science, 2017, 12 (8), pp.e0183841. 〈10.1371/journal.pone.0183841〉. 〈inserm-01635467〉

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