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Journal articles
Prognostic value of FDG-PET indices for the assessment of histological response to neoadjuvant chemotherapy and outcome in pediatric patients with Ewing sarcoma and osteosarcoma
Abstract : Purpose The objective of this retrospective work was to evaluate the prognostic value on histological response and survival of quantitative indices derived from FDG-PET performed before and after chemotherapy (CHT), in a homogeneous pediatric Ewing sarcoma (EWS) and Osteo-sarcoma (OST) population. Methods Thirty-one patients with EWS and 31 with OST were included. All patients were treated with neoadjuvant CHT, and underwent surgery for local control. All patients had FDG-PET at diagnosis and after CHT, prior to surgery. Several parameters were evaluated: SUVmax, SUVpeak, SUVmean, metabolic tumor volume, total lesion glycolysis, 7 textural features and 3 shape features (SF). The segmentation was performed using an adaptive approach. Results were compared to histopathological regression of the resected tumor and to clinical follow-up for survival evaluation.
Cited literature [34 references]
https://www.hal.inserm.fr/inserm-01635467
Contributor : Elizabeth Bernardo <>
Submitted on : Wednesday, November 15, 2017 - 11:18:37 AM
Last modification on : Friday, June 19, 2020 - 3:08:51 AM
Long-term archiving on: : Friday, February 16, 2018 - 12:53:26 PM
Contributor : Elizabeth Bernardo <>
Submitted on : Wednesday, November 15, 2017 - 11:18:37 AM
Last modification on : Friday, June 19, 2020 - 3:08:51 AM
Long-term archiving on: : Friday, February 16, 2018 - 12:53:26 PM
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