Skip to Main content Skip to Navigation
Journal articles

Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion

Abstract : Glucagon-like peptide 1 (GLP-1) is a hormone released from enteroendocrine L cells. Although first described as a glucoregulatory incretin hormone, GLP-1 also suppresses inflammation and promotes mucosal integrity. Here, we demonstrate that plasma GLP-1 levels are rapidly increased by lipopolysaccharide (LPS) administration in mice via a Toll-like receptor 4 (TLR4)-dependent mechanism. Experimental manipulation of gut barrier integrity after dextran sodium sulfate treatment, or via ischemia/reperfusion experiments in mice, triggered a rapid rise in circulating GLP-1. This phenomenon was detected prior to measurable changes in inflammatory status and plasma cytokine and LPS levels. In human subjects, LPS administration also induced GLP-1 secretion. Furthermore, GLP-1 levels were rapidly increased following the induction of ischemia in the human intestine. These findings expand traditional concepts of enteroendocrine L cell biology to encompass the sensing of inflammatory stimuli and compromised mucosal integrity, linking glucagon-like peptide secretion to gut inflammation.
Document type :
Journal articles
Complete list of metadatas

Cited literature [40 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01628611
Contributor : Stéphane Mandard <>
Submitted on : Friday, November 3, 2017 - 5:39:25 PM
Last modification on : Tuesday, September 1, 2020 - 3:46:09 PM
Long-term archiving on: : Sunday, February 4, 2018 - 2:41:20 PM

File

Lebrun L Cell Reports 2017.pdf
Files produced by the author(s)

Identifiers

Citation

Lorène J Lebrun, Kaatje Lenaerts, Dorien Kiers, Jean-Paul Pais de Barros, Naïg Le Guern, et al.. Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion. Cell Reports, Elsevier Inc, 2017, 21 (5), pp.1160-1168. ⟨10.1016/j.celrep.2017.10.008⟩. ⟨inserm-01628611⟩

Share

Metrics

Record views

273

Files downloads

366