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Molecular and Functional Characterization of Lymphoid Progenitor Subsets Reveals a Bipartite Architecture of Human Lymphopoiesis.

Abstract : The classical model of hematopoiesis established in the mouse postulates that lymphoid cells originate from a founder population of common lymphoid progenitors. Here, using a modeling approach in humanized mice, we showed that human lymphoid development stemmed from distinct populations of CD127- and CD127+ early lymphoid progenitors (ELPs). Combining molecular analyses with in vitro and in vivo functional assays, we demonstrated that CD127- and CD127+ ELPs emerged independently from lympho-mono-dendritic progenitors, responded differently to Notch1 signals, underwent divergent modes of lineage restriction, and displayed both common and specific differentiation potentials. Whereas CD127- ELPs comprised precursors of T cells, marginal zone B cells, and natural killer (NK) and innate lymphoid cells (ILCs), CD127+ ELPs supported production of all NK cell, ILC, and B cell populations but lacked T potential. On the basis of these results, we propose a "two-family" model of human lymphoid development that differs from the prevailing model of hematopoiesis.
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https://www.hal.inserm.fr/inserm-01624830
Contributor : Kutaiba Alhaj Hussen <>
Submitted on : Thursday, October 26, 2017 - 5:45:52 PM
Last modification on : Friday, October 16, 2020 - 3:21:18 AM

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Kutaiba Alhaj Hussen, Thien-Phong Manh, Fabien Guimiot, Elisabeth Nelson, Emna Chabaane, et al.. Molecular and Functional Characterization of Lymphoid Progenitor Subsets Reveals a Bipartite Architecture of Human Lymphopoiesis.. Immunity, Elsevier, 2017, 47 ((4)), pp.680-696.e8. ⟨10.1016/j.immuni.2017.09.009⟩. ⟨inserm-01624830⟩

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