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Journal articles
Associations between residual depressive symptoms, cognition, and functioning in patients with euthymic bipolar disorder: results from the FACE-BD cohort
Paul Roux
1, 2
Aurélie Raust
3
Anne-Sophie Cannavo
Valérie Aubin
4
Bruno Aouizerate
5
Jean-Michel Azorin
6
Frank Bellivier
3
Raoul Belzeaux
6
Thierry Bougerol
4
Iréna Cussac
4
Philippe Courtet
7
Bruno Etain
3
Sébastien Gard
4
Sophie Job
8
Jean-Pierre Kahn
4
Marion Leboyer
9
Emilie Olié
10
Chantal Henry
3
Christine Passerieux
2, 1
Aurélie Raust Msc
Bruno Aouizerate 5
Author
Jean-Michel Azorin 6
Author
Frank Bellivier 3
Author
Raoul Belzeaux 6
Author
Sébastien Gard 4
Author
Sophie Job 8
Author
Jean-Pierre Kahn 4
Author Employer institution : Université de Lorraine
Marion Leboyer 9
Author
Emilie Olié 10
Author
Chantal Henry 3
Author
Christine Passerieux 2, 1
Author
Aurélie Raust Msc
Author
1
CHV - Centre Hospitalier de Versailles André Mignot (Versailles, Trappes, Andrésy et Bois d'Arcy, Chesnay - France)
2
HANDIReSP - Laboratoire de recherches cliniques et en santé publique sur les handicaps psychique, cognitif et moteur (Hôpital Mignot
177 rue de Versailles
78157 Le Chesnay - France)
- UVSQ - Université de Versailles Saint-Quentin-en-Yvelines : EA7405 (55 avenue de Paris - 78035 Versailles cedex - France)
3
Service de psychiatrie (Créteil - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- Hôpital Henri Mondor (France)
- Hôpital Albert Chenevier (France)
4
Fondation FondaMental [Créteil] (Hôpital Albert Chenevier, Pôle de Psychiatrie, 40 rue de Mesly, 94000 Créteil France - France)
5
Hôpital Charles Perrens (France)
6
Pôle de Psychiatrie Universitaire Solaris, Marseille (France)
- Hôpitaux Sud - Hôpital Sainte-Marguerite [CHU - APHM] (270, boulevard de Sainte-Marguerite 13274 Marseille cedex 9 - France)
7
Neuropsychiatrie : recherche épidémiologique et clinique (Hôpital La Colombière 39 AV Charles Flahault BP 34493 -Pav 42 Calixte Cavalier 34093 CEDEX 5 Montpellier - France)
- UM1 - Université Montpellier 1 (5, boulevard Henri IV - CS 19044 - 34967 Montpellier cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1061 (101, rue de Tolbiac, 75013 Paris - France)
- UM - Université de Montpellier (163 rue Auguste Broussonnet - 34090 Montpellier - France)
8
QUARTZ - Laboratoire QUARTZ (Supméca - 3 rue Fernand Hainaut - 93400 Saint-Ouen cedex - France)
- UP8 - Université Paris 8 Vincennes-Saint-Denis : EA7393 (2 rue de la Liberté - 93526 Saint-Denis cedex - France)
- SUPMECA - Institut supérieur de mécanique de Paris : EA7393 (3 rue Fernand Hainaut, 93400 Saint-Ouen - France)
- ENSEA - Ecole Nationale Supérieure de l'Electronique et de ses Applications : EA7393 (6 avenue du Ponceau - CS 20 707 Cergy - 95014 Cergy-Pontoise Cedex - France)
- EISTI - Ecole Internationale des Sciences du Traitement de l'Information : EA7393 (Avenue du Parc, 95000 Cergy - France)
9
IMRB - Institut Mondor de Recherche Biomédicale (8 rue du Général Sarrail 94010 Créteil - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U955 (101, rue de Tolbiac, 75013 Paris - France)
- UPEC UP12 - Université Paris-Est Créteil Val-de-Marne - Paris 12 : UMR955 (61 avenue du Général de Gaulle - 94010 Créteil cedex - France)
- IFR10 (France)
10
Urgence et post-urgence psychiatrique (371, avenue du Doyen Gaston Giraud 34295 Montpellier cedex 5 - France)
- CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier] (191 avenue du doyen Gaston Giraud 34295 Montpellier cedex 5 - France)
- Hôpital Lapeyronie (France)
Abstract : BackgroundThe relationship between residual depressive symptoms, cognition and functioning in patients with euthymic bipolar disorder is a subject of debate.AimsTo assess whether cognition mediates the association between residual depressive symptoms and functioning in patients with bipolar disorder who were euthymic.MethodWe included 241 adults with euthymic bipolar disorder in a multicentre cross-sectional study. We used a battery of tests to assess six cognition domains. A path analysis was then used to perform a mediation analysis of the relationship between residual depressive symptoms, cognitive components and functioning.ResultsOnly verbal and working memory were significantly associated with better functioning. Residual depressive symptoms were associated with poorer functioning. No significant relationship was found between residual depressive symptoms and any cognitive component.ConclusionsCognition and residual depressive symptoms appear to be two independent sources of variation in the functioning of people with euthymic bipolar disorder.
Document type :
Journal articles
Complete list of metadatas
https://www.hal.inserm.fr/inserm-01621507
Contributor : Paul Roux <>
Submitted on : Monday, October 23, 2017 - 3:39:28 PM
Last modification on : Friday, October 23, 2020 - 4:35:41 PM
Long-term archiving on: : Wednesday, January 24, 2018 - 3:02:36 PM
Contributor : Paul Roux <>
Submitted on : Monday, October 23, 2017 - 3:39:28 PM
Last modification on : Friday, October 23, 2020 - 4:35:41 PM
Long-term archiving on: : Wednesday, January 24, 2018 - 3:02:36 PM
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BJP-2017-201335-Roux (1).pdf
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Identifiers
- HAL Id : inserm-01621507, version 1
- PUBMED : 29051175
- DOI : 10.1192/bjp.bp.117.201335
Collections
IMRB | U1061 | UPEC-UPEM | SUPMECA | BS | UNIV-MONTPELLIER | UVSQ | QUARTZ | UPEC | UNIV-PARIS8 | UNIV-PARIS-LUMIERES
Citation
Paul Roux, Aurélie Raust, Anne-Sophie Cannavo, Valérie Aubin, Bruno Aouizerate, et al.. Associations between residual depressive symptoms, cognition, and functioning in patients with euthymic bipolar disorder: results from the FACE-BD cohort. British Journal of Psychiatry, Royal College of Psychiatrists, 2017, ⟨10.1192/bjp.bp.117.201335⟩. ⟨inserm-01621507⟩
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