C. Ober and T. Yao, The genetics of asthma and allergic disease: a 21st century perspective, Immunological Reviews, vol.127, issue.Suppl, pp.10-30, 2011.
DOI : 10.1038/sj.jid.5700739

D. Welter, J. Macarthur, J. Morales, T. Burdett, P. Hall et al., The NHGRI GWAS Catalog, a curated resource of SNP-trait associations, Nucleic Acids Research, vol.42, issue.D1, pp.1001-1007, 2014.
DOI : 10.1093/nar/gkt1229

K. Bonnelykke, R. Sparks, J. Waage, and J. Milner, Genetics of allergy and allergic sensitization: common variants, rare mutations, Current Opinion in Immunology, vol.36, pp.115-141, 2015.
DOI : 10.1016/j.coi.2015.08.002

H. Los, P. Postmus, and D. Boomsma, Asthma Genetics and Intermediate Phenotypes: A Review From Twin Studies, Twin Research, vol.4, issue.2, pp.81-93, 2001.
DOI : 10.1375/1369052012191
URL : http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.78.1809&rep=rep1&type=pdf

S. Thomsen, C. Ulrik, K. Kyvik, M. Ferreira, and V. Backer, Multivariate genetic analysis of atopy phenotypes in a selected sample of twins, Clinical & Experimental Allergy, vol.40, issue.3, pp.1382-90, 2006.
DOI : 10.1046/j.1365-2222.2001.01161.x

D. Vercelli, Discovering susceptibility genes for asthma and allergy, Nature Reviews Immunology, vol.114, issue.3, pp.169-82, 2008.
DOI : 10.4049/jimmunol.169.4.1893

F. Castro-giner, M. Bustamante, R. Gonzalez, J. Kogevinas, M. Jarvis et al., A 459 pooling-based genome-wide analysis identifies new potential candidate genes for atopy in the European 460

A. Ramasamy, I. Curjuric, L. Coin, A. Kumar, W. Mcardle et al., A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order, Journal of Allergy and Clinical Immunology, vol.128, issue.5, pp.996-1005, 2011.
DOI : 10.1016/j.jaci.2011.08.030

X. Sun, Q. Lu, S. Mukherjee, P. Crane, R. Elston et al., Analysis pipeline for the epistasis search 477 -statistical versus biological filtering, Front Genet, vol.5, pp.106-478, 2014.

Y. Luo, G. Riedlinger, and P. Szolovits, Text mining in cancer gene and pathway prioritization. Cancer 482, Inform, vol.13, pp.69-79, 2014.
DOI : 10.4137/cin.s13874
URL : http://insights.sagepub.com/redirect_file.php?fileId=5911&filename=4428-CIN-Text-Mining-in-Cancer-Gene-and-Pathway-Prioritization.pdf&fileType=pdf

F. Kauffmann, M. Dizier, I. Annesi-maesano, J. Bousquet, D. Charpin et al., EGEA 487 (Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness 488 and atopy)--descriptive characteristics, Clin Exp Allergy, vol.29, issue.4, pp.17-21, 1999.

E. Bouzigon, R. Nadif, L. Moual, N. Dizier, M. Aschard et al., Genetic and 493 environmental factors of asthma and allergy: Results of the EGEA study], Rev Mal Respir, vol.494, issue.32, pp.822-862, 2015.

C. Laprise, The Saguenay-Lac-Saint-Jean asthma familial collection: the genetics of asthma in a young founder population, Genes and Immunity, vol.26, issue.4, pp.247-55, 2014.
DOI : 10.1093/bioinformatics/btq419

M. Moffatt, M. Kabesch, L. Liang, A. Dixon, D. Strachan et al., Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma, Nature, vol.16, issue.7152, pp.470-473, 2007.
DOI : 10.1164/ajrccm/136.1.225

M. Moffatt, I. Gut, F. Demenais, D. Strachan, E. Bouzigon et al., A Large-Scale, Consortium-Based Genomewide Association Study of Asthma, New England Journal of Medicine, vol.363, issue.13, pp.1211-1232, 2010.
DOI : 10.1056/NEJMoa0906312
URL : https://hal.archives-ouvertes.fr/inserm-00748663

C. Sarnowski, P. Sugier, R. Granell, D. Jarvis, M. Dizier et al., Identification of a new locus at 502 16q12 associated with time to asthma onset, J Allergy Clin Immunol, p.503, 2016.

Y. Li and G. Abecasis, Mach 1.0: Rapid haplotype reconstruction and missing genotype inference, Am. J, p.507

Y. Li, C. Willer, S. Sanna, and G. Abecasis, Genotype Imputation, Annual Review of Genomics and Human Genetics, vol.10, issue.1, pp.387-406, 2009.
DOI : 10.1146/annurev.genom.9.081307.164242

M. Li, J. Yeung, S. Cherny, and P. Sham, Evaluating the effective numbers of independent tests and significant p-value thresholds in commercial genotyping arrays and public imputation reference datasets, Human Genetics, vol.271, issue.5254, pp.747-56, 2012.
DOI : 10.1126/science.271.5254.1380

C. Herold, M. Steffens, F. Brockschmidt, M. Baur, and T. Becker, INTERSNP: genome-wide interaction analysis guided by a priori information, Bioinformatics, vol.25, issue.24, pp.3275-81, 2009.
DOI : 10.1093/bioinformatics/btp596
URL : https://academic.oup.com/bioinformatics/article-pdf/25/24/3275/647157/btp596.pdf

J. Li and J. L. , Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix, Heredity, vol.62, issue.3, pp.221-228, 2005.
DOI : 10.1002/1098-2272(200012)19:4<323::AID-GEPI4>3.0.CO;2-5

W. Cochran, THE COMPARISON OF PERCENTAGES IN MATCHED SAMPLES, Biometrika, vol.37, issue.3-4, pp.256-66, 1950.
DOI : 10.1093/biomet/37.3-4.256

L. Ward and M. Kellis, HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants, Nucleic Acids Research, vol.40, issue.D1, pp.930-934, 2012.
DOI : 10.1093/nar/gkr917

M. Fliegauf, T. Benzing, and H. Omran, When cilia go bad: cilia defects and ciliopathies, Nat Rev Mol Cell, vol.523
DOI : 10.1038/nrm2317
URL : http://www.nature.com/nrm/journal/v9/n1/pdf/nrm2317.pdf

T. Besnard, C. Vache, D. Baux, L. Larrieu, C. Abadie et al., Non-USH2A mutations in USH2 patients, Human Mutation, vol.11, issue.3, pp.504-514, 2012.
DOI : 10.1089/1066527041410418
URL : https://hal.archives-ouvertes.fr/inserm-00650795

M. Leigh, M. Zariwala, and M. Knowles, Primary ciliary dyskinesia: improving the diagnostic approach, Current Opinion in Pediatrics, vol.21, issue.3, pp.320-325, 2009.
DOI : 10.1097/MOP.0b013e328329cddb
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665363/pdf

M. Armengot, D. Salom, M. Diaz-llopis, J. Millan, J. Milara et al., Nasal Ciliary Beat Frequency and Beat Pattern in Retinal Ciliopathies, Investigative Opthalmology & Visual Science, vol.53, issue.4, pp.2076-2085, 2012.
DOI : 10.1167/iovs.11-8666
URL : http://iovs.arvojournals.org/data/journals/iovs/933465/i1552-5783-53-4-2076.pdf

D. Bonneau, R. F. Kremer, C. Klossek, J. Kaplan, J. Patte et al., Usher syndrome type I associated with bronchiectasis and immotile nasal cilia in two brothers., Journal of Medical Genetics, vol.30, issue.3, pp.253-257, 1993.
DOI : 10.1136/jmg.30.3.253
URL : http://jmg.bmj.com/content/jmedgenet/30/3/253.full.pdf

J. Lee, M. Mcdonald, M. Cho, E. Wan, P. Castaldi et al., DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease, Respiratory Research, vol.137, issue.1, pp.97-540, 2014.
DOI : 10.1378/chest.09-1504

M. Kovacic, J. Myers, N. Wang, L. Martin, M. Lindsey et al., Identification of KIF3A as a Novel Candidate Gene for Childhood Asthma Using RNA Expression and Population Allelic Frequencies Differences, PLoS ONE, vol.31, issue.8, pp.23714-543, 2011.
DOI : 10.1371/journal.pone.0023714.t005

M. Dizier, R. Nadif, P. Margaritte-jeannin, S. Barton, C. Sarnowski et al., gene and early smoke exposure in bronchial hyperresponsiveness, European Respiratory Journal, vol.47, issue.4, pp.1072-81, 2016.
DOI : 10.1183/13993003.00849-2015