C. Andreu-agullo, J. Morante-redolat, A. Delgado, and I. Farinas, Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone, Nature Neuroscience, vol.2, issue.12, pp.1514-1537, 2009.
DOI : 10.1242/jcs.00062

S. Bao, Q. Wu, R. Mclendon, Y. Hao, Q. Shi et al., Glioma stem cells promote radioresistance by preferential activation of the DNA damage response, Nature, vol.8, issue.7120, pp.756-60, 2006.
DOI : 10.1038/nature05236

B. Beck, G. Driessens, S. Goossens, K. Youssef, A. Kuchnio et al., A vascular niche and a VEGF???Nrp1 loop regulate the initiation and stemness of skin tumours, Nature, vol.126, issue.7369, pp.399-403, 2011.
DOI : 10.1038/nprot.2009.120

A. Brame, J. Maguire, P. Yang, A. Dyson, R. Torella et al., Design, Characterization, and First-In-Human Study of the Vascular Actions of a Novel Biased Apelin Receptor Agonist, Hypertension, vol.65, issue.4, pp.834-874, 2015.
DOI : 10.1161/HYPERTENSIONAHA.114.05099

R. Bowman, Q. Wang, A. Carro, R. Verhaak, and M. Squatrito, GlioVis data portal for visualization and analysis of brain tumor expression datasets, Neuro-Oncology, vol.19, issue.1, pp.139-180, 2017.
DOI : 10.1093/neuonc/now247

C. Brown, D. Alizadeh, R. Starr, L. Weng, J. Wagner et al., Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy, New England Journal of Medicine, vol.375, issue.26, pp.2561-2570, 2016.
DOI : 10.1056/NEJMoa1610497

C. Calabrese, H. Poppleton, M. Kocak, T. Hogg, C. Fuller et al., A Perivascular Niche for Brain Tumor Stem Cells, Cancer Cell, vol.11, issue.1, pp.69-82, 2007.
DOI : 10.1016/j.ccr.2006.11.020

Z. Cao, B. Ding, P. Guo, S. Lee, J. Butler et al., Angiocrine Factors Deployed by Tumor Vascular Niche Induce B Cell Lymphoma Invasiveness and Chemoresistance, Cancer Cell, vol.25, issue.3, pp.350-65, 2014.
DOI : 10.1016/j.ccr.2014.02.005

Z. Cao, J. Scandura, G. Inghirami, K. Shido, B. Ding et al., Molecular Checkpoint Decisions Made by Subverted Vascular Niche Transform Indolent Tumor Cells into Chemoresistant Cancer Stem Cells, Cancer Cell, vol.31, issue.1, pp.110-136, 2017.
DOI : 10.1016/j.ccell.2016.11.010

J. Chen, Y. Li, T. Yu, R. Mckay, D. Burns et al., A restricted cell population propagates glioblastoma growth after chemotherapy, Nature, vol.2, issue.7412, pp.522-528, 2012.
DOI : 10.1038/nature11287

O. Chinot, W. Wick, W. Mason, R. Henriksson, F. Saran et al., Bevacizumab plus Radiotherapy???Temozolomide for Newly Diagnosed Glioblastoma, New England Journal of Medicine, vol.370, issue.8, pp.709-731, 2014.
DOI : 10.1056/NEJMoa1308345

T. Chou, Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method, Cancer Research, vol.70, issue.2, pp.440-446, 2010.
DOI : 10.1158/0008-5472.CAN-09-1947

S. Dubois, A. C. Wu, Y. Leclair, H. Leveau, C. Schol et al., A catalytic-independent role for the LUBAC in NF-??B activation upon antigen receptor engagement and in lymphoma cells, Blood, vol.123, issue.14, pp.2199-203, 2014.
DOI : 10.1182/blood-2013-05-504019

P. Evers, P. Lee, J. Demarco, N. Agazaryan, J. Sayre et al., Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma, BMC Cancer, vol.105, issue.1, p.384, 2010.
DOI : 10.1002/ijc.11033

C. Folkins, S. Man, P. Xu, Y. Shaked, D. Hicklin et al., Anticancer Therapies Combining Antiangiogenic and Tumor Cell Cytotoxic Effects Reduce the Tumor Stem-Like Cell Fraction in Glioma Xenograft Tumors, Cancer Research, vol.67, issue.8, pp.3560-3564, 2007.
DOI : 10.1158/0008-5472.CAN-06-4238

A. Fournel, A. Drougard, T. Duparc, M. A. Brierley, S. Castro et al., Apelin targets gut contraction to control glucose metabolism via the brain, Gut, vol.25, issue.2, pp.258-69, 2015.
DOI : 10.1111/nmo.12152

E. Galan-moya, L. Guelte, A. , L. Fernandes, E. Thirant et al., Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway, EMBO reports, vol.19, issue.5, pp.470-476, 2011.
DOI : 10.1038/sj.onc.1208311

E. Galan-moya, L. Treps, L. Oliver, H. Chneiweiss, F. Vallette et al., Endothelial Secreted Factors Suppress Mitogen Deprivation-Induced Autophagy and Apoptosis in Glioblastoma Stem-Like Cells, PLoS ONE, vol.13, issue.3, p.93505, 2014.
DOI : 10.1371/journal.pone.0093505.g004

URL : https://hal.archives-ouvertes.fr/inserm-01075054

M. Garcia-barros, F. Paris, C. Cordon-cardo, D. Lyden, S. Rafii et al., Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis, Science, vol.300, issue.5622, pp.1155-1164, 2003.
DOI : 10.1126/science.1082504

J. Hale, M. Sinyuk, J. Rich, and J. Lathia, Decoding the cancer stem cell hypothesis in glioblastoma, CNS Oncology, vol.28, issue.4, pp.319-349, 2013.
DOI : 10.1002/stem.542

E. Harford-wright, N. Bidere, and J. Gavard, β-escin selectively targets the glioblastoma-initiating cell population and reduces cell viability, Oncotarget, vol.7, issue.41, pp.66865-79, 2016.
DOI : 10.18632/oncotarget.11784

Y. Hu and G. Smyth, ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays, Journal of Immunological Methods, vol.347, issue.1-2, pp.70-78, 2009.
DOI : 10.1016/j.jim.2009.06.008

R. Kaelin, M. Kretz, A. Meyer, A. Kispert, F. Heppner et al., Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis, Developmental Biology, vol.305, issue.2, pp.599-614, 2007.
DOI : 10.1016/j.ydbio.2007.03.004

M. Kleinz and A. Davenport, Emerging roles of apelin in biology and medicine, Pharmacology & Therapeutics, vol.107, issue.2, pp.198-211, 2005.
DOI : 10.1016/j.pharmthera.2005.04.001

J. Lathia, S. Mack, E. Mulkearns-hubert, C. Valentim, and J. Rich, Cancer stem cells in glioblastoma, Genes & Development, vol.29, issue.12, pp.1203-1220, 2015.
DOI : 10.1101/gad.261982.115

A. Luissint, C. Federici, F. Guillonneau, F. Chretien, L. Camoin et al., Guanine Nucleotide-Binding Protein G??i2: A New Partner of Claudin-5 that Regulates Tight Junction Integrity in Human Brain Endothelial Cells, Journal of Cerebral Blood Flow & Metabolism, vol.31, issue.3, pp.860-73, 2012.
DOI : 10.1038/jcbfm.2010.121

N. Macaluso, S. Pitkin, J. Maguire, A. Davenport, and R. Glen, Discovery of a Competitive Apelin Receptor (APJ) Antagonist, ChemMedChem, vol.306, issue.6, pp.1017-1040, 2011.
DOI : 10.1038/sj.bjp.0703939

J. Maguire, M. Kleinz, S. Pitkin, and A. Davenport, [Pyr1]Apelin-13 Identified as the Predominant Apelin Isoform in the Human Heart: Vasoactive Mechanisms and Inotropic Action in Disease, Hypertension, vol.54, issue.3, pp.598-604, 2009.
DOI : 10.1161/HYPERTENSIONAHA.109.134619

A. Schafer, J. Teufel, F. Ringel, M. Bettstetter, I. Hoepner et al., Aldehyde dehydrogenase 1A1???a new mediator of resistance to temozolomide in glioblastoma, Neuro-Oncology, vol.14, issue.12, pp.1452-64, 2012.
DOI : 10.1093/neuonc/nos270

M. Scimia, C. Hurtado, S. Ray, S. Metzler, K. Wei et al., APJ acts as a dual receptor in cardiac hypertrophy, Nature, vol.96, issue.7411, pp.394-402, 2012.
DOI : 10.1161/01.CIR.96.9.3053

T. Shingu, A. Ho, L. Yuan, X. Zhou, C. Dai et al., Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation, Nature Genetics, vol.24, issue.1, pp.75-86, 2017.
DOI : 10.1016/j.ccr.2013.08.001

S. Singh, C. Hawkins, I. Clarke, J. Squire, J. Bayani et al., Identification of human brain tumour initiating cells, Nature, vol.64, issue.7015, pp.396-401, 2004.
DOI : 10.1093/jnen/61.3.215

R. Stupp, M. Hegi, W. Mason, M. Van-den-bent, M. Taphoorn et al., Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial, The Lancet Oncology, vol.10, issue.5, pp.459-66, 2009.
DOI : 10.1016/S1470-2045(09)70025-7

R. Stupp, S. Taillibert, A. Kanner, S. Kesari, D. Steinberg et al., Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma, JAMA, vol.314, issue.23, pp.2535-2578, 2015.
DOI : 10.1001/jama.2015.16669

L. Treps, S. Edmond, E. Harford-wright, E. Galan-moya, A. Schmitt et al., Extracellular vesicle-transported Semaphorin3A promotes vascular permeability in glioblastoma, Oncogene, vol.119, issue.20, pp.2615-2638, 2016.
DOI : 10.1038/ncomms7999

URL : https://hal.archives-ouvertes.fr/inserm-01406334

V. Tropepe, M. Sibilia, B. Ciruna, J. Rossant, E. Wagner et al., Distinct Neural Stem Cells Proliferate in Response to EGF and FGF in the Developing Mouse Telencephalon, Developmental Biology, vol.208, issue.1, pp.166-88, 1999.
DOI : 10.1006/dbio.1998.9192

K. Yan, K. Yang, and J. Rich, The evolving landscape of glioblastoma stem cells, Current Opinion in Neurology, vol.26, issue.6, pp.701-708, 2013.
DOI : 10.1097/WCO.0000000000000032

L. Zhang, K. Takara, D. Yamakawa, H. Kidoya, and N. Takakura, Apelin as a marker for monitoring the tumor vessel normalization window during antiangiogenic therapy, Cancer Science, vol.8, issue.8, pp.36-44, 2016.
DOI : 10.1016/j.ejheart.2005.10.007