Complement as a regulator of adaptive immunity

Abstract : The complement system is an ancient and evolutionarily conserved effector system comprising in mammals over 50 circulating and membrane bound proteins. Complement has long been described as belonging to the innate immune system; however, a number of recent studies have demonstrated its key role in the modulation of the adaptive immune response. This review does not set out to be an exhaustive list of the numerous interactions of the many complement components with adaptive immunity; rather, we will focus more precisely on the role of some complement molecules in the regulation of antigen presenting cells, as well as on their direct effect on the activation of the core adaptive immune cells, B and T lymphocytes. Recent reports on the local production and activation of complement proteins also suggest a major role in the control of effector responses. The crucial role of complement in adaptive immunity is further highlighted by several examples of dysregulation of these pathways in human diseases.
Type de document :
Article dans une revue
Seminars in Immunopathology, Springer Verlag, 2017, Epub ahead of print. 〈10.1007/s00281-017-0644-y〉
Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-01593213
Contributeur : Anne Astier <>
Soumis le : lundi 25 septembre 2017 - 20:52:52
Dernière modification le : mercredi 12 septembre 2018 - 17:32:03
Document(s) archivé(s) le : mardi 26 décembre 2017 - 14:29:35

Fichier

Astier - Sem in ImmuPat.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Justin Killick, Gregoire Morisse, Dirk Sieger, Anne Astier. Complement as a regulator of adaptive immunity. Seminars in Immunopathology, Springer Verlag, 2017, Epub ahead of print. 〈10.1007/s00281-017-0644-y〉. 〈inserm-01593213〉

Partager

Métriques

Consultations de la notice

97

Téléchargements de fichiers

50