Cognitive and imaging markers in non-demented subjects attending a memory clinic: study design and baseline findings of the MEMENTO cohort - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Alzheimer's Research and Therapy Année : 2017

Cognitive and imaging markers in non-demented subjects attending a memory clinic: study design and baseline findings of the MEMENTO cohort

1 ISPED - Institut de Santé Publique, d'Epidémiologie et de Développement
2 ICM - Institut du Cerveau = Paris Brain Institute
3 LEASP - Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps
4 Hématopoïèse normale et pathologique
5 LPMC - Laboratoire de physique de la matière condensée
6 Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
7 Groupe hospitalier Broca
8 CHU Bordeaux
9 Département de neurologie [Montpellier]
10 Service de neurologie et de neuropsychologie
11 LPPL - Laboratoire de Psychologie des Pays de la Loire
12 HCL - Hospices Civils de Lyon
13 CMRR Nice - Centre Mémoire de Ressources et de Recherche [Nice]
14 GEPEA - Laboratoire de génie des procédés - environnement - agroalimentaire
15 CHU Amiens-Picardie
16 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
17 SNA - EPIS - Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé
18 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
19 CHU Rouen
20 DCAC - Défaillance Cardiovasculaire Aiguë et Chronique
21 ToNIC - Toulouse NeuroImaging Center
22 CHU de Poitiers - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
23 LPNC - Laboratoire de Psychologie et NeuroCognition
24 iBraiN - Imaging, Brain & Neuropsychiatry
25 Service de Neurologie [Strasbourg]
26 Service de neurologie [Nantes]
27 NPsy-Sydo - Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux
28 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
29 CATI - Centre d'Acquisition et de Traitement des Images [Paris] = CATI Multicenter Neuroimaging Platform
30 BPH - Bordeaux population health
31 NEUROSPIN - Service NEUROSPIN
32 LIB - Laboratoire d'Imagerie Biomédicale [Paris]
33 LNAO - Laboratoire de Neuroimagerie Assistée par Ordinateur
34 UB - Université de Bordeaux
Bruno Dubois
  • Fonction : Auteur
  • PersonId : 893169
Sandrine Harston
  • Fonction : Auteur
Olivier Godefroy
David Wallon
Jérémie Pariente
  • Fonction : Auteur
  • PersonId : 960621
Caroline Hommet
  • Fonction : Auteur
  • PersonId : 946617
Claire Boutoleau-Bretonnière
  • Fonction : Auteur
  • PersonId : 1290711
  • IdRef : 073681458
Grégory Operto

Résumé

Background The natural history and disease mechanisms of Alzheimer’s disease and related disorders (ADRD) are still poorly understood. Very few resources are available to scrutinise patients as early as needed and to use integrative approaches combining standardised, repeated clinical investigations and cutting-edge biomarker measurements. Methods In the nationwide French MEMENTO cohort study, participants were recruited in memory clinics and screened for either isolated subjective cognitive complaints (SCCs) or mild cognitive impairment (MCI; defined as test performance 1.5 SD below age, sex and education-level norms) while not demented (Clinical Dementia Rating [CDR] <1). Baseline data collection included neurological and physical examinations as well as extensive neuropsychological testing. To be included in the MEMENTO cohort, participants had to agree to undergo both brain magnetic resonance imaging (MRI) and blood sampling. Cerebral 18F-fluorodeoxyglucose positon emission tomography and lumbar puncture were optional. Automated analyses of cerebral MRI included assessments of volumes of whole-brain, hippocampal and white matter lesions. Results The 2323 participants, recruited from April 2011 to June 2014, were aged 71 years, on average (SD 8.7), and 62% were women. CDR was 0 in 40% of participants, and 30% carried at least one apolipoprotein E ε4 allele. We observed that more than half (52%) of participants had amnestic mild cognitive impairment (17% single-domain aMCI), 32% had non-amnestic mild cognitive impairment (16.9% single-domain naMCI) and 16% had isolated SCCs. Multivariable analyses of neuroimaging markers associations with cognitive categories showed that participants with aMCI had worse levels of imaging biomarkers than the others, whereas participants with naMCI had markers at intermediate levels between SCC and aMCI. The burden of white matter lesions tended to be larger in participants with aMCI. Independently of CDR, all neuroimaging and neuropsychological markers worsened with age, whereas differences were not consistent according to sex. Conclusions MEMENTO is a large cohort with extensive clinical, neuropsychological and neuroimaging data and represents a platform for studying the natural history of ADRD in a large group of participants with different subtypes of MCI (amnestic or not amnestic) or isolated SCCs.
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Dates et versions

inserm-01580853 , version 2 (03-09-2017)
inserm-01580853 , version 1 (25-05-2021)

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Carole Dufouil, Bruno Dubois, Bruno Vellas, Florence Pasquier, Frédéric Blanc, et al.. Cognitive and imaging markers in non-demented subjects attending a memory clinic: study design and baseline findings of the MEMENTO cohort. Alzheimer's Research and Therapy, 2017, 9 (1), pp.67. ⟨10.1186/s13195-017-0288-0⟩. ⟨inserm-01580853v1⟩
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