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Survey of diagnostic and treatment practices for multiple sclerosis in Europe

O. Fernández 1, * M. Delvecchio 2 Gilles Edan 3, 4 S. Fredrikson 5 G. Gionvannoni 6 P. Hartung 7 E. Havrdova 8 L. Kappos 9 C. Pozzilli 10 P. Soerensen 11 B. Tackenberg 12 Patrick Vermersch 13, 14 G. Comi 15
* Corresponding author
1 Hospital Regional Universitario Carlos Haya
2 SDA Bocconi Scuola di Direzione Aziendale
3 Service de Neurologie [Rennes]
4 VisAGeS - Vision, Action et Gestion d'informations en Santé
INSERM - Institut National de la Santé et de la Recherche Médicale : U1228, Inria Rennes – Bretagne Atlantique , IRISA-D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE
5 Department of Clinical Neurosciences, Neurology Division, Karolinska Institutet
6 Queen Mary's School of Medicine and Dentistry
7 departmet of Neurology
8 Department of neurology
9 Department of Neurology [Suisse]
10 Department of Neurological Sciences
11 Danish Multiple Sclerosis Research Centre
12 Department of Neurology
13 CHU Lille
14 Inflammation: mécanismes et régulation et interactions avec la nutrition et les candidoses
15 Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute,
Abstract : Background and purpose - Up-to-date information is needed on the extent to which neurologists treating multiple sclerosis (MS) in Europe are integrating rapidly evolving diagnostic criteria, disease-modifying therapies and recommendations for monitoring disease activity into their clinical practice. Methods - A steering committee of MS neurologists used a modified Delphi process to develop case- and practice-based questions for two sequential surveys distributed to MS neurologists throughout Europe. Case-based questions were developed for radiologically isolated syndrome (RIS), clinically isolated syndrome (CIS), relapsing-remitting MS (RRMS) and RRMS with breakthrough disease. Results - Multiple sclerosis neurologists from 11 European countries responded to survey 1 (n = 233) and survey 2 (n = 171). Respondents agreed that they would not treat the patients in the RIS or CIS cases but would treat a patient with a relatively mild form of RRMS. Choice of treatment was evenly distributed among first-line injectables and oral treatments for mild RRMS, and moved to second-line treatment as the RRMS case increased in severity. Additional results on RRMS with breakthrough disease are presented. Conclusions - Although there was general agreement on some aspects of treatment, responses to other management and clinical practice questions varied considerably. These results, which reflect current clinical practice patterns, highlight the need for additional MS treatment education and awareness and may help inform the development of MS practice guidelines in Europe.
Keywords : radiologically isolated syndrome clinically isolated syndrome relapsing−remitting
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https://www.hal.inserm.fr/inserm-01576518
Contributor : Christian Barillot <>
Submitted on : Wednesday, August 23, 2017 - 12:28:21 PM
Last modification on : Wednesday, March 17, 2021 - 10:30:50 AM

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INSERM | CNRS | UNIV-RENNES1 | IRISA | INRIA | UR1-UFR-ISTIC | UNIV-RENNES | UNIV-LILLE | INSA-RENNES | CENTRALESUPELEC

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O. Fernández, M. Delvecchio, Gilles Edan, S. Fredrikson, G. Gionvannoni, et al.. Survey of diagnostic and treatment practices for multiple sclerosis in Europe. European Journal of Neurology, Wiley, 2017, 24 (3), pp.516 - 522. ⟨10.1111/ene.13236⟩. ⟨inserm-01576518⟩

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