Skip to Main content Skip to Navigation
Journal articles

Virus-induced double-membrane vesicles: Virus-induced DMVs

Abstract : Many viruses that replicate in the cytoplasm compartmentalise their genome replication and transcription in specific subcellular microenvironments or organelle-like structures, to increase replication efficiency and protect against host cell defences. Recent studies have investigated the complex membrane rearrangements induced by diverse positive-strand RNA viruses, which are of two morphotypes : membrane invagination towards the lumen of the endoplasmic reticulum (ER) or other specifically targeted organelles and double-membrane vesicles (DMVs) formed by extrusion of the ER membrane. DMVs resemble small autophagosomes and the viruses inducing these intriguing organelles are known to promote autophagy, suggesting a potential link between DMVs and the autophagic pathway. In this review, we summarise recent findings concerning the biogenesis, architecture and role of DMVs in the life cycle of viruses from different families, and discuss their possible connection to autophagy or other related pathways.
Document type :
Journal articles
Complete list of metadatas

Cited literature [40 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01575078
Contributor : Philippe Roingeard <>
Submitted on : Thursday, August 17, 2017 - 5:13:33 PM
Last modification on : Thursday, July 11, 2019 - 4:04:02 PM

Files

CMI_2015.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Emmanuelle Blanchard, Philippe Roingeard. Virus-induced double-membrane vesicles: Virus-induced DMVs. Cellular Microbiology, Wiley, 2014, 17 (1), pp.45-50. ⟨10.4161/auto.4782⟩. ⟨inserm-01575078⟩

Share

Metrics

Record views

219

Files downloads

653