Glioblastoma: From Molecular Pathology to Targeted Treatment, Annual Review of Pathology: Mechanisms of Disease, vol.9, issue.1, pp.1-25, 2014. ,
DOI : 10.1146/annurev-pathol-011110-130324
Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma, New England Journal of Medicine, vol.352, issue.10, pp.987-996, 2005. ,
DOI : 10.1056/NEJMoa043330
Isolation of cancer stem cells from adult glioblastoma multiforme, Oncogene, vol.23, issue.58, pp.9392-9400, 2004. ,
DOI : 10.1038/sj.onc.1208311
Cancer stem cells in glioblastoma, Genes & Development, vol.29, issue.12, pp.1203-1217, 2015. ,
DOI : 10.1101/gad.261982.115
Evolution of the Cancer Stem Cell Model, Cell Stem Cell, vol.14, issue.3, pp.275-291, 2014. ,
DOI : 10.1016/j.stem.2014.02.006
A Perivascular Niche for Brain Tumor Stem Cells, Cancer Cell, vol.11, issue.1, pp.69-82, 2007. ,
DOI : 10.1016/j.ccr.2006.11.020
Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway, EMBO reports, vol.19, issue.5, pp.470-476, 2011. ,
DOI : 10.1038/sj.onc.1208311
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090013
Endothelial Secreted Factors Suppress Mitogen Deprivation-Induced Autophagy and Apoptosis in Glioblastoma Stem-Like Cells, PLoS ONE, vol.13, issue.3, p.93505, 2014. ,
DOI : 10.1371/journal.pone.0093505.g004
URL : https://hal.archives-ouvertes.fr/inserm-01075054
Endothelial cells induce cancer stem cell features in differentiated glioblastoma cells via bFGF, Molecular Cancer, vol.9, issue.1, p.157, 2015. ,
DOI : 10.1016/j.ccr.2006.02.019
Bevacizumab plus Radiotherapy???Temozolomide for Newly Diagnosed Glioblastoma, New England Journal of Medicine, vol.370, issue.8, pp.709-722, 2014. ,
DOI : 10.1056/NEJMoa1308345
URL : http://umu.diva-portal.org/smash/get/diva2:725879/FULLTEXT01
A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma, New England Journal of Medicine, vol.370, issue.8, pp.699-708, 2014. ,
DOI : 10.1056/NEJMoa1308573
Antiangiogenic Therapy for Glioblastoma: Current Status and Future Prospects, Clinical Cancer Research, vol.20, issue.22, pp.5612-5619, 2014. ,
DOI : 10.1158/1078-0432.CCR-14-0834
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234180
Stem Cell???like Glioma Cells Promote Tumor Angiogenesis through Vascular Endothelial Growth Factor, Cancer Research, vol.66, issue.16, pp.7843-7848, 2006. ,
DOI : 10.1158/0008-5472.CAN-06-1010
Glioma Tumor Stem-Like Cells Promote Tumor Angiogenesis and Vasculogenesis via Vascular Endothelial Growth Factor and Stromal-Derived Factor 1, Cancer Research, vol.69, issue.18, pp.7243-7251, 2009. ,
DOI : 10.1158/0008-5472.CAN-09-0167
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409689
Extracellular vesicle-transported Semaphorin3A promotes vascular permeability in glioblastoma, Oncogene, vol.119, issue.20, pp.2615-2623, 2016. ,
DOI : 10.1038/ncomms7999
URL : https://hal.archives-ouvertes.fr/inserm-01406334
Semaphorin 3A elevates endothelial cell permeability through PP2A inactivation, Journal of Cell Science, vol.125, issue.17, pp.4137-4146, 2012. ,
DOI : 10.1242/jcs.108282
URL : https://hal.archives-ouvertes.fr/hal-01541442
Biological properties of extracellular vesicles and their physiological functions, Journal of Extracellular Vesicles, vol.40, issue.1, p.27066, 2015. ,
DOI : 10.1093/nar/gks658
Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles, Annual Review of Cell and Developmental Biology, vol.30, issue.1, pp.255-289, 2014. ,
DOI : 10.1146/annurev-cellbio-101512-122326
Extracellular Vesicles and MicroRNAs: Their Role in Tumorigenicity and Therapy for Brain Tumors, Cellular and Molecular Neurobiology, vol.19, issue.3, pp.361-376, 2016. ,
DOI : 10.1038/mt.2011.164
Extracellular vesicles shed by glioma cells: pathogenic role and clinical value, Tumor Biology, vol.119, issue.2, pp.8425-8438, 2014. ,
DOI : 10.3171/2013.3.JNS122226
Spitting out the demons: Extracellular vesicles in glioblastoma, Cell Adhesion & Migration, vol.6, issue.2, pp.1-9, 2016. ,
DOI : 10.1093/neuonc/nov170
URL : https://hal.archives-ouvertes.fr/inserm-01382405
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers, Nature Cell Biology, vol.94, issue.12, pp.1470-1476, 2008. ,
DOI : 10.1371/journal.pone.0000571
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423894
Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development, Proceedings of the National Academy of Sciences, vol.12, issue.1, pp.7312-7317, 2013. ,
DOI : 10.1038/ncb2000
Extracellular Vesicles from Metastatic Rat Prostate Tumors Prime the Normal Prostate Tissue to Facilitate Tumor Growth, Scientific Reports, vol.30, issue.1, p.31805, 2016. ,
DOI : 10.1093/nar/30.9.e36
Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-?B. Sci Rep, p.5750, 2015. ,
The role of extracellular vesicles in mediating progression, metastasis and potential treatment of hepatocellular carcinoma, Oncotarget, vol.8, pp.3683-3695, 2017. ,
DOI : 10.18632/oncotarget.12465
Communication by Extracellular Vesicles: Where We Are and Where We Need to Go, Cell, vol.164, issue.6, pp.1226-1232, 2016. ,
DOI : 10.1016/j.cell.2016.01.043
Standardization of sample collection, isolation and analysis methods in extracellular vesicle research, Journal of Extracellular Vesicles, vol.117, issue.1, 2013. ,
DOI : 10.1182/blood-2010-11-318691
Comparative marker analysis of extracellular vesicles in different human cancer types, Journal of Extracellular Vesicles, vol.57, issue.1, 2013. ,
DOI : 10.1016/j.lungcan.2007.01.032
Blood-brain barrier-specific properties of a human adult brain endothelial cell line, The FASEB Journal, vol.19, issue.13, pp.1872-1874, 2005. ,
DOI : 10.1096/fj.04-3458fje
In vitro assays of angiogenesis for assessment of angiogenic and anti-angiogenic agents, Microvascular Research, vol.74, issue.2-3, pp.2-3172, 2007. ,
DOI : 10.1016/j.mvr.2007.05.006
Jumping the barrier: VE-cadherin, VEGF and other angiogenic modifiers in cancer, Biology of the Cell, vol.63, issue.12, pp.593-605, 2011. ,
DOI : 10.1158/1078-0432.CCR-10-0839
Exosomes isolated from plasma of glioma patients enrolled in a vaccination trial reflect antitumor immune activity and might predict survival, OncoImmunology, vol.52, issue.6, p.1008347, 2015. ,
DOI : 10.1373/clinchem.2013.213850
Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA, proteins, and metabolites, Oncotarget, vol.6, issue.7, pp.4953-4967, 2015. ,
DOI : 10.18632/oncotarget.3211
URL : https://hal.archives-ouvertes.fr/inserm-01179843
Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity, Matrix Biology, vol.31, issue.4, pp.229-233, 2012. ,
DOI : 10.1016/j.matbio.2012.02.005
Vascular Permeability Factor/Vascular Endothelial Growth Factor and the Significance of Microvascular Hyperpermeability in Angiogenesis ,
DOI : 10.1007/978-3-642-59953-8_6
Vascular permeability, vascular hyperpermeability and angiogenesis, Angiogenesis, vol.237, issue.Pt 6, pp.109-119, 2008. ,
DOI : 10.1016/S0002-9440(10)64337-4
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2480489
SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types, Cancer Res, vol.59, issue.1, pp.99-106, 1999. ,
Safety, Pharmacokinetic, and Antitumor Activity of SU11248, a Novel Oral Multitarget Tyrosine Kinase Inhibitor, in Patients With Cancer, Journal of Clinical Oncology, vol.24, issue.1, pp.25-35, 2006. ,
DOI : 10.1200/JCO.2005.02.2194
The Prognostic Significance of Combining VEGFA, FLT1 and KDR mRNA Expressions in Brain Tumors, Journal of Cancer, vol.6, issue.9, pp.812-818, 2015. ,
DOI : 10.7150/jca.11975
Autocrine VEGF???VEGFR2???Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth, The Journal of Experimental Medicine, vol.63, issue.3, pp.507-520, 2012. ,
DOI : 10.1038/sj.cr.7310126
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302235/pdf
Intracrine VEGF Signaling Mediates the Activity of Prosurvival Pathways in Human Colorectal Cancer Cells, Cancer Research, vol.76, issue.10, pp.3014-3024, 2016. ,
DOI : 10.1158/0008-5472.CAN-15-1605
Autocrine VEGF Signaling Synergizes with EGFR in Tumor Cells to Promote Epithelial Cancer Development, Cell, vol.140, issue.2, pp.268-279, 2010. ,
DOI : 10.1016/j.cell.2009.12.046
VEGF contributes to mammary tumor growth in transgenic mice through paracrine and autocrine mechanisms, Laboratory Investigation, vol.349, issue.5, pp.608-623, 2005. ,
DOI : 10.1128/MCB.12.3.954
Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells, Cancer Res, vol.61, issue.15, pp.5736-5740, 2001. ,
VEGF Exerts an Angiogenesis-Independent Function in Cancer Cells to Promote Their Malignant Progression, Cancer Research, vol.72, issue.16, pp.3912-3918, 2012. ,
DOI : 10.1158/0008-5472.CAN-11-4058
A novel association of neuropilin-1 and MUC1 in pancreatic ductal adenocarcinoma: role in induction of VEGF signaling and angiogenesis, Oncogene, vol.265, issue.43, pp.5608-5618, 2016. ,
DOI : 10.3390/cancers3044102
VEGF targets the tumour cell, Nature Reviews Cancer, vol.73, issue.12, pp.871-882, 2013. ,
DOI : 10.1158/0008-5472.CAN-13-0529
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011842
DNA sequences within glioma-derived extracellular vesicles can cross the intact Blood-Brain Barrier and be detected in peripheral blood of patients, Oncotarget, 2016. ,
DOI : 10.18632/oncotarget.13635
Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy, Nature Medicine, vol.52, issue.12, pp.1835-1840, 2012. ,
DOI : 10.1002/anie.201100101
Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth, Oncotarget, vol.6, issue.31, pp.31413-31427, 2015. ,
DOI : 10.18632/oncotarget.5105
From glioblastoma to endothelial cells through extracellular vesicles: messages for angiogenesis, Tumor Biology, vol.453, issue.3, pp.12743-12753, 2016. ,
DOI : 10.1016/j.bbrc.2014.09.068
Bioavailability of VEGF in Tumor-Shed Vesicles Depends on Vesicle Burst Induced by Acidic pH, Neoplasia, vol.8, issue.2, pp.96-103, 2006. ,
DOI : 10.1593/neo.05583
Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells, Journal of Biological Chemistry, vol.265, issue.49, pp.34211-34222, 2009. ,
DOI : 10.1016/j.tcb.2008.03.002
Extracellular Vesicles from Neural Stem Cells Transfer IFN-?? via Ifngr1 to Activate Stat1 Signaling in Target Cells, Molecular Cell, vol.56, issue.2, pp.193-204, 2014. ,
DOI : 10.1016/j.molcel.2014.08.020
A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis, Nature Communications, vol.45, p.14450, 2017. ,
DOI : 10.1021/bi0606795
VEGF Promotes Proliferation of Human Glioblastoma Multiforme Stem-Like Cells through VEGF Receptor 2, The Scientific World Journal, vol.13, issue.5, p.417413, 2013. ,
DOI : 10.3390/ijms13056424
Downregulation of VEGF expression attenuates malignant biological behavior of C6 glioma stem cells, International Journal of Oncology, vol.44, issue.5, pp.1581-1588, 2014. ,
DOI : 10.3892/ijo.2014.2331
VEGF-A acts via neuropilin-1 to enhance epidermal cancer stem cell survival and formation of aggressive and highly vascularized tumors, Oncogene, vol.492, issue.33, pp.4379-4387, 2016. ,
DOI : 10.1038/nature11606
Glioblastoma microvesicles promote endothelial cell proliferation through Akt/beta-catenin pathway, Int J Clin Exp Pathol, vol.7, issue.8, pp.4857-4866, 2014. ,
IKK/ NF-kappaB signaling contributes to glioblastoma stem cell maintenance, Oncotarget, 2016. ,
DOI : 10.18632/oncotarget.12507
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342468
Blockade of TGF-?? Signaling by the TGF??R-I Kinase Inhibitor LY2109761 Enhances Radiation Response and Prolongs Survival in Glioblastoma, Cancer Research, vol.71, issue.23, pp.7155-7167, 2011. ,
DOI : 10.1158/0008-5472.CAN-11-1212
Expansive growth of two glioblastoma stem-like cell lines is mediated by bFGF and not by EGF, Radiology and Oncology, vol.47, issue.4, pp.330-337, 2013. ,
DOI : 10.2478/raon-2013-0063
Circulating endothelial progenitor cells in malignant gliomas, Journal of Neurosurgery, vol.112, issue.1, pp.43-49, 2010. ,
DOI : 10.3171/2009.5.JNS081074
A new mosaic pattern in glioma vascularization: exogenous endothelial progenitor cells integrating into the vessels containing tumor-derived endothelial cells, Oncotarget, vol.5, issue.7, pp.1955-1968, 2014. ,
DOI : 10.18632/oncotarget.1885
Elevated circulating levels of tissue factor-positive microvesicles are associated with distant metastasis in lung cancer, Journal of Cancer Research and Clinical Oncology, vol.125, issue.7, pp.61-67, 2014. ,
DOI : 10.1002/ijc.24479
Extracellular vesicles swarm the cancer microenvironment: from tumor???stroma communication to drug intervention, Oncogene, vol.10, issue.7, pp.877-884, 2017. ,
DOI : 10.15252/embj.201592484
Circulating biomarkers for gliomas, Nature Reviews Neurology, vol.24, issue.10, pp.556-566, 2015. ,
DOI : 10.1097/WCO.0b013e32834cd415
Desert Hedgehog/Patch2 Axis Contributes to Vascular Permeability and Angiogenesis in Glioblastoma, Frontiers in Pharmacology, vol.44, issue.Pt 17, p.281, 2015. ,
DOI : 10.1097/MPA.0000000000000532
URL : https://hal.archives-ouvertes.fr/inserm-01247505
The guanine exchange factor SWAP70 mediates vGPCR-induced endothelial plasticity, Cell Communication and Signaling, vol.13, issue.1, p.11, 2015. ,
DOI : 10.1593/tlo.09172
URL : https://hal.archives-ouvertes.fr/inserm-01264495
Assaying the Action of Secreted Semaphorins on Vascular Permeability, Methods Mol Biol, vol.144, issue.2, pp.417-427, 2017. ,
DOI : 10.1038/onc.2015.317
The E3 ubiquitin ligase MARCH3 controls the endothelial barrier, FEBS Letters, vol.28, issue.20, pp.3660-3668, 2016. ,
DOI : 10.1016/j.ccell.2015.10.004
URL : https://hal.archives-ouvertes.fr/inserm-01385212
GlioVis data portal for visualization and analysis of brain tumor expression datasets, Neuro-Oncology, vol.19, issue.1, pp.139-141, 2017. ,
DOI : 10.1093/neuonc/now247