Guillain-Barré Syndrome and Chikungunya: Description of All Cases Diagnosed during the 2014 Outbreak in the French West Indies

Stephanie Balavoine; Mathilde Pircher; Bruno Hoen; Cecile Herrmann-Storck; Fatiha Najioullah; Benjamin Madeux; Aissatou Signate; Ruddy Valentino; Annie Lannuzel; Magali Saint Louis; Sylvie Cassadou; André Cabié; Kinda Schepers

doi:10.4269/ajtmh.15-0753

Guillain-Barré Syndrome and Chikungunya: Description of All Cases Diagnosed during the 2014 Outbreak in the French West Indies

Stephanie Balavoine ¹ Mathilde Pircher ² Bruno Hoen ^{1, 3, 4} Cecile Herrmann-Storck ⁵ Fatiha Najioullah ⁶ Benjamin Madeux ⁷ Aissatou Signate ⁸ Ruddy Valentino ⁹ Annie Lannuzel ^{10, 11, 4} Magali Saint Louis ¹² Sylvie Cassadou ¹³ André Cabié ^{2, 3, 4} Kinda Schepers ¹

1 Service des Maladies Infectieuses et Tropicales [Point-à-Pitre, Guadeloupe]

2 Service de Maladies Infectieuses et Tropicales [Fort-de-France, Martinique]

3 CIC - Antilles Guyane - Centre d'investigation clinique Antilles-Guyane

4 Faculté de médecine Hacynthe Bastaraud [Pointe-à-Pitre, Guadeloupe]

5 Laboratoire de virologie [Point-à-Pitre, Guadeloupe]

6 Laboratoire de Virologie [Fort-de-France, Martinique]

7 Service de réanimation [Point-à-Pitre, Guadeloupe]

8 Service de neurologie [Fort-de-France, Martinique]

9 Service de réanimation [Fort-de-France, Martinique]

10 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute

11 Service de Neurologie [Pointe-à-Pitre, Guadeloupe]

12 Service de Soins de Suite et Réadaptation [Pointe-à-Pitre, Guadeloupe]

13 Santé publique France

Abstract : The Guillain–Barré syndrome (GBS) has been reported as a possible complication of acute chikungunya infection. The chikungunya epidemics, which occurred in Martinique and Guadeloupe in 2014, affected 308,000 people in these two islands. GBS occurred during or immediately after acute chikungunya infection in 13 patients (10 men, three women; mean age: 61 years). Median time from acute chikungunya to GBS onset was 9 days. Twelve patients were treated with intravenous polyvalent immunoglobulins, nine of whom improved within 7 days. Five of 13 patients required mechanical ventilation. Two patients with severe GBS died. At 6 months of follow-up, 7/13 achieved a good functional recovery with no or minor residual symptoms. A 2-fold increase in incidence was observed during the year of chikungunya outbreak. This study supports prior reports suggesting that GBS may be a complication of chikungunya.

Type de document :

Article dans une revue

American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2017, 97 (2), pp.356 - 360. 〈10.4269/ajtmh.15-0753〉

Domaine :

Sciences du Vivant [q-bio] / Santé publique et épidémiologie

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https://www.hal.inserm.fr/inserm-01572511
Contributeur : Inserm Cic1424 Centre d'Investigation Clinique Antilles Guyane <>
Soumis le : lundi 7 août 2017 - 16:26:37
Dernière modification le : jeudi 7 février 2019 - 16:07:14

Guillain-Barré Syndrome and Chikungunya: Description of All Cases Diagnosed during the 2014 Outbreak in the French West Indies

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Guillain-Barré Syndrome and Chikungunya: Description of All Cases Diagnosed during the 2014 Outbreak in the French West Indies

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