Circadian control of metabolism and pathological consequences of clock perturbations.

Alicia Mayeuf-Louchart 1 Mathilde Zecchin 1 Bart Staels 1, * Hélène Duez 1, *
* Auteur correspondant
1 Récepteurs nucléaires, maladies cardiovasculaires et diabète EGID FR 3508
Institut Pasteur de Lille, INSERM - Institut National de la Santé et de la Recherche Médicale : U1011, Université de Lille, Droit et Santé, CHRU Lille - Centre Hospitalier Régional Universitaire [Lille]
Abstract : Most organisms have developed an autonomous time-keeping system that generates self-sustained daily fluctuations in behavior and physiological processes. These biological clocks are reset every day by light to adjust physiology to the day/night cycle generated by the rotation of the Earth. Clocks present in organs involved in glucose and lipid metabolism such as the liver, muscle, adipose tissue and pancreas are also reset by feeding cues which permits the local integration of systemic and nutritional signals to switch fuel production and utilization according to the feeding/fasting cycle. However, derangements in this finely tuned system can be induced by extending light exposure, 24/7 food availability and altered food intake patterns, repeated jet-lag and shift-working, promoting metabolic imbalances ranging from body weight gain to the development of insulin resistance and liver diseases. Here, we review recent findings on the link between the clock and metabolic fluxes to maintain whole-body homeostasis, and what clock disruption in mice has revealed about the role of the clock in metabolic regulation.
Type de document :
Article dans une revue
Biochimie, Elsevier, 2017, Epub ahead of print. 〈10.1016/j.biochi.2017.07.017〉
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Contributeur : Marie-Hélène Derudas <>
Soumis le : lundi 7 août 2017 - 08:45:04
Dernière modification le : lundi 8 octobre 2018 - 17:44:09




Alicia Mayeuf-Louchart, Mathilde Zecchin, Bart Staels, Hélène Duez. Circadian control of metabolism and pathological consequences of clock perturbations.. Biochimie, Elsevier, 2017, Epub ahead of print. 〈10.1016/j.biochi.2017.07.017〉. 〈inserm-01572343〉



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