Iterative fecal microbiota transplantations for eradicating digestive colonization with carbapenemase-producing Enterobacteriaceae: is it worth it?

Abstract : Carbapenemase-producing Enterobacteriaceae (CPE) have emerged as a major source of bacterial resistance and their dissemination is a serious public health threat.1 It has also been demonstrated that those bacteria could disseminate outside the hospital setting. A large study including 34 hospitals in Spain demonstrated that a significant proportion of patients identified as colonized or infected with CPE during hospitalization probably acquired this multi-resistant organism in a nursing home during the period preceding their hospital admission.2 In addition, a recent review of the literature demonstrated that according to US-based studies, the percentage of CPE isolates that could be associated with the community ranged from 5.6 to 10.8%.3