B. Liege, . Louis, I. Ap-hp, V. Paris, H. Ap-hp et al., 5 Department of Hematology, Institut Paoli Calmettes 6 Erasmus Medical Center-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands. 7 Department of Hematology, Hospital Saint Antoine CHU Nantes, vol.8, issue.2 4

M. Eapen, V. Rocha, G. Sanz, A. Scaradavou, M. Zhang et al., Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis, The Lancet Oncology, vol.11, issue.7, pp.653-60, 2010.
DOI : 10.1016/S1470-2045(10)70127-3

F. Baron, M. Labopin, A. Ruggeri, M. Mohty, G. Sanz et al., Unrelated cord blood transplantation for adult patients with acute myeloid leukemia: higher incidence of acute graft-versus-host disease and lower survival in male patients transplanted with female unrelated cord blood?a report from Eurocord, the Acute Leukemia Working Party, and the Cord Blood Committee of the Cellular Therapy and Immunobiology Working Party of the European Group for Blood and Marrow Transplantation, Journal of Hematology & Oncology, vol.18, issue.3, p.107, 2015.
DOI : 10.1097/00007890-197410000-00001

K. Ballen and L. H. , Cord blood transplant for acute myeloid leukaemia, British Journal of Haematology, vol.20, issue.Suppl 2, pp.25-36, 2016.
DOI : 10.1016/j.bbmt.2014.02.020

F. Milano, T. Gooley, B. Wood, A. Woolfrey, M. Flowers et al., Cord-Blood Transplantation in Patients with Minimal Residual Disease, New England Journal of Medicine, vol.375, issue.10, pp.944-53, 2016.
DOI : 10.1056/NEJMoa1602074

J. Barker, D. Weisdorf, T. Defor, B. Blazar, J. Miller et al., Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced-intensity conditioning, Blood, vol.102, issue.5, pp.1915-1924, 2003.
DOI : 10.1182/blood-2002-11-3337

C. Brunstein, E. Fuchs, S. Carter, C. Karanes, L. Costa et al., Alternative donor transplantation after reduced intensity conditioning: results of parallel phase 2 trials using partially HLA-mismatched related bone marrow or unrelated double umbilical cord blood grafts, Blood, vol.118, issue.2, pp.282-290, 2011.
DOI : 10.1182/blood-2011-03-344853

J. Somers, E. Braakman, B. Van-der-holt, E. Petersen, E. Marijt et al., Rapid induction of single donor chimerism after double umbilical cord blood transplantation preceded by reduced intensity conditioning: results of the HOVON 106 phase II study, Haematologica, vol.99, issue.11, pp.1753-61, 2014.
DOI : 10.3324/haematol.2014.106690

L. Tucunduva, A. Ruggeri, G. Sanz, S. Furst, G. Socie et al., Risk factors for outcomes after unrelated cord blood transplantation for adults with acute lymphoblastic leukemia: a report on behalf of Eurocord and the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation, Bone Marrow Transplantation, vol.90, issue.7, pp.887-94, 2014.
DOI : 10.1182/blood-2012-06-379040

B. Rio, S. Chevret, S. Vigouroux, P. Chevallier, S. Furst et al., Decreased Nonrelapse Mortality after Unrelated Cord Blood Transplantation for Acute Myeloid Leukemia Using Reduced-Intensity Conditioning: A Prospective Phase II Multicenter Trial, Biology of Blood and Marrow Transplantation, vol.21, issue.3, pp.445-53, 2015.
DOI : 10.1016/j.bbmt.2014.11.009

R. Devillier, S. Harbi, S. Furst, R. Crocchiolo, J. El-cheikh et al., Poor Outcome with Nonmyeloablative Conditioning Regimen before Cord Blood Transplantation for Patients with High-Risk Acute Myeloid Leukemia Compared with Matched Related or?Unrelated Donor Transplantation, Biology of Blood and Marrow Transplantation, vol.20, issue.10, pp.1560-1565, 2014.
DOI : 10.1016/j.bbmt.2014.06.006
URL : http://doi.org/10.1016/j.bbmt.2014.06.006

F. Baron, A. Ruggeri, E. Beohou, M. Labopin, G. Sanz et al., RIC <i>versus</i> MAC UCBT in adults with AML: A report from Eurocord, the ALWP and the CTIWP of the EBMT, Oncotarget, vol.7, pp.43027-43065, 2016.
DOI : 10.18632/oncotarget.9599

K. Ballen, E. Gluckman, and H. Broxmeyer, Umbilical cord blood transplantation: the first 25 years and beyond, Blood, vol.122, issue.4, pp.491-499, 2013.
DOI : 10.1182/blood-2013-02-453175
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952633

J. Barker, D. Weisdorf, T. Defor, B. Blazar, P. Mcglave et al., Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy, Blood, vol.105, issue.3, pp.1343-1350, 2005.
DOI : 10.1182/blood-2004-07-2717

C. Brunstein, J. Gutman, D. Weisdorf, A. Woolfrey, T. Defor et al., Allogeneic hematopoietic cell transplantation for hematologic malignancy: relative risks and benefits of double umbilical cord blood, Blood, vol.116, issue.22, pp.4693-4702, 2010.
DOI : 10.1182/blood-2010-05-285304

M. Verneris, C. Brunstein, J. Barker, M. Macmillan, T. Defor et al., Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 units, Blood, vol.114, issue.19, pp.4293-4302, 2009.
DOI : 10.1182/blood-2009-05-220525

C. Lamers, R. Wijers, C. Van-bergen, J. Somers, E. Braakman et al., CD4+ T-cell alloreactivity toward mismatched HLA class II alleles early after double umbilical cord blood transplantation, Blood, vol.128, issue.17, pp.2165-74, 2016.
DOI : 10.1182/blood-2016-06-718619

A. Ruggeri, G. Sanz, H. Bittencourt, J. Sanz, A. Rambaldi et al., Comparison of outcomes after single or double cord blood transplantation in adults with acute leukemia using different types of myeloablative conditioning regimen, a retrospective study on behalf of Eurocord and the Acute Leukemia Working Party of EBMT, Leukemia, vol.100, issue.4, pp.779-86, 2014.
DOI : 10.1182/blood.V98.8.2332

W. Jr, J. Eapen, M. Carter, S. Wang, Y. Schultz et al., One-unit versus two-unit cord-blood transplantation for hematologic cancers, N Engl J Med, vol.371, pp.1685-94, 2014.

G. Michel, C. Galambrun, A. Sirvent, C. Pochon, B. Bruno et al., Single- vs double-unit cord blood transplantation for children and young adults with acute leukemia or myelodysplastic syndrome, Blood, vol.127, issue.26, pp.3450-3457, 2016.
DOI : 10.1182/blood-2016-01-694349
URL : https://hal.archives-ouvertes.fr/hal-01482531

O. Ringden, M. Labopin, G. Ehninger, D. Niederwieser, R. Olsson et al., Reduced Intensity Conditioning Compared With Myeloablative Conditioning Using Unrelated Donor Transplants in Patients With Acute Myeloid Leukemia, Journal of Clinical Oncology, vol.27, issue.27, pp.4570-4577, 2009.
DOI : 10.1200/JCO.2008.20.9692

F. Baron, M. Labopin, D. Niederwieser, S. Vigouroux, J. Cornelissen et al., Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation, Leukemia, vol.11, issue.12, pp.2462-2470, 2012.
DOI : 10.1056/NEJMoa1108188

S. Avery, W. Shi, M. Lubin, A. Gonzales, G. Heller et al., Influence of infused cell dose and HLA match on engraftment after double-unit cord blood allografts, Blood, vol.117, issue.12, pp.3277-85, 2011.
DOI : 10.1182/blood-2010-08-300491

H. Glucksberg, R. Storb, A. Fefer, C. Buckner, P. Neiman et al., CLINICAL MANIFESTATIONS OF GRAFT-VERSUS-HOST DISEASE IN HUMAN RECIPIENTS OF MARROW FROM HL-A-MATCHED SIBLING DONOR,S, Transplantation, vol.18, issue.4, pp.295-304, 1974.
DOI : 10.1097/00007890-197410000-00001

A. Ruggeri, M. Labopin, F. Ciceri, M. Mohty, and A. Nagler, Definition of GvHD-free, relapse-free survival for registry-based studies: an ALWP?EBMT analysis on patients with AML in remission, Bone Marrow Transplantation, vol.18, issue.4, pp.610-611, 2016.
DOI : 10.3324/haematol.2013.092254

S. Lewis and M. Clarke, Forest plots: trying to see the wood and the trees, BMJ, vol.322, issue.7300, pp.1479-80, 2001.
DOI : 10.1136/bmj.322.7300.1479
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1120528/pdf

J. Wagner, J. Rosenthal, R. Sweetman, X. Shu, S. Davies et al., Successful transplantation of HLAmatched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft-versus-host disease, Blood, vol.88, pp.795-802, 1996.

E. Gluckman, V. Rocha, A. Boyer-chammard, F. Locatelli, W. Arcese et al., Outcome of Cord-Blood Transplantation from Related and Unrelated Donors, New England Journal of Medicine, vol.337, issue.6, pp.373-81, 1997.
DOI : 10.1056/NEJM199708073370602

J. Wagner, J. Barker, T. Defor, K. Baker, B. Blazar et al., Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatmentrelated mortality and survival, Blood, vol.100, pp.1611-1619, 2002.

A. Stanevsky, A. Shimoni, R. Yerushalmi, and A. Nagler, Double umbilical cord blood transplant: more than a cell dose? Leuk Lymphoma, pp.975-82, 2010.
DOI : 10.3109/10428191003699886

A. Scaradavou, C. Brunstein, M. Eapen, J. Le-rademacher, J. Barker et al., Double unit grafts successfully extend the application of umbilical cord blood transplantation in adults with acute leukemia, Blood, vol.121, issue.5, pp.752-760, 2013.
DOI : 10.1182/blood-2012-08-449108

F. Baron and R. Storb, Hematopoietic cell transplantation after reduced-intensity conditioning for older adults with acute myeloid leukemia in complete remission, Current Opinion in Hematology, vol.14, issue.2, pp.145-51, 2007.
DOI : 10.1097/MOH.0b013e3280168462

A. Shimoni, M. Labopin, B. Savani, L. Volin, G. Ehninger et al., Long-term survival and late events after allogeneic stem cell transplantation from HLA-matched siblings for acute myeloid leukemia with myeloablative compared to reduced-intensity conditioning: a report on behalf of the acute leukemia working party of European group for blood and marrow transplantation, Journal of Hematology & Oncology, vol.48, issue.9, p.118, 2016.
DOI : 10.1038/bmt.2012.258

J. Sanz, J. Wagner, M. Sanz, T. Defor, P. Montesinos et al., Myeloablative Cord Blood Transplantation in Adults with Acute Leukemia: Comparison of Two Different Transplant Platforms, Biology of Blood and Marrow Transplantation, vol.19, issue.12, pp.1725-1755, 2013.
DOI : 10.1016/j.bbmt.2013.09.015

C. Saygin and H. Carraway, Emerging therapies for acute myeloid leukemia, Journal of Hematology & Oncology, vol.2, issue.5, p.93, 2017.
DOI : 10.1038/bcj.2012.14

G. Ehx, G. Fransolet, L. De-leval, D. Hondt, S. Lucas et al., Azacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects, OncoImmunology, vol.133, issue.5, p.1314425, 2017.
DOI : 10.1073/pnas.1000475107

G. Fransolet, G. Ehx, J. Somja, L. Delens, M. Hannon et al., Azacytidine mitigates experimental sclerodermic chronic graft-versus-host disease, Journal of Hematology & Oncology, vol.400, issue.1, p.53, 2016.
DOI : 10.1038/23287
URL : http://doi.org/10.1186/s13045-016-0281-2

J. Liu, J. Zhong, X. Zhang, and C. Zhang, Allogeneic CD19-CAR-T cell infusion after allogeneic hematopoietic stem cell transplantation in B cell malignancies, Journal of Hematology & Oncology, vol.9, issue.1, p.35, 2017.
DOI : 10.1186/s13045-016-0299-5
URL : http://doi.org/10.1186/s13045-017-0405-3

J. Sanz and R. Gale, One or two umbilical cord blood cell units? Caveat emptor, Bone Marrow Transplantation, vol.3, issue.3, pp.341-344, 2017.
DOI : 10.1038/bmt.2012.163

L. Pascal, M. Mohty, A. Ruggeri, L. Tucunduva, N. Milpied et al., Impact of rabbit ATG-containing myeloablative conditioning regimens on the outcome of patients undergoing unrelated single-unit cord blood transplantation for hematological malignancies, Bone Marrow Transplantation, vol.96, issue.1, pp.45-50, 2015.
DOI : 10.1016/S1083-8791(03)00127-7

L. Pascal, L. Tucunduva, A. Ruggeri, D. Blaise, P. Ceballos et al., Impact of ATG-containing reduced-intensity conditioning after single- or double-unit allogeneic cord blood transplantation, Blood, vol.126, issue.8, pp.1027-1059, 2015.
DOI : 10.1182/blood-2014-09-599241

O. Shimony, A. Nagler, Y. Gellman, E. Refaeli, N. Rosenblum et al., Anti-T Lymphocyte Globulin (ATG) Induces Generation of Regulatory T Cells, at Least Part of Them Express Activated CD44, Journal of Clinical Immunology, vol.96, issue.1, pp.173-88, 2012.
DOI : 10.1210/jc.2010-1424

G. Ehx, M. Hannon, Y. Beguin, S. Humblet-baron, and F. Baron, Validation of a multicolor staining to monitor phosphoSTAT5 levels in regulatory T-cell subsets, Oncotarget, vol.6, pp.43255-66, 2015.

F. Baron, P. Zachee, J. Maertens, T. Kerre, A. Ory et al., Non-myeloablative allogeneic hematopoietic cell transplantation following fludarabine plus 2?Gy TBI or ATG plus 8?Gy TLI: a phase II randomized study from the Belgian Hematological Society, Journal of Hematology & Oncology, vol.8, issue.1, p.4, 2015.
DOI : 10.1016/j.bbmt.2005.09.004

G. Socie, C. Schmoor, W. Bethge, H. Ottinger, M. Stelljes et al., Chronic graft-versus-host disease: long-term results from a randomized trial on graft-versus-host disease prophylaxis with or without anti-T-cell globulin ATG-Fresenius, Blood, vol.117, issue.23, pp.6375-82, 2011.
DOI : 10.1182/blood-2011-01-329821

M. Rubio, D. Aveni-piney, M. Labopin, M. Hamladji, R. Sanz et al., Impact of in vivo T cell depletion in HLA-identical allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission conditioned with a fludarabine iv-busulfan myeloablative regimen: a report from the EBMT Acute Leukemia Working Party, Journal of Hematology & Oncology, vol.17, issue.2, p.31, 2017.
DOI : 10.1016/S1470-2045(15)00462-3
URL : https://hal.archives-ouvertes.fr/inserm-01444368

R. Admiraal, C. Lindemans, C. Van-kesteren, M. Bierings, A. Versluijs et al., Excellent T-cell reconstitution and survival depend on low ATG exposure after pediatric cord blood transplantation, Blood, vol.128, issue.23, pp.2734-2775, 2016.
DOI : 10.1182/blood-2016-06-721936

M. Rubio, B. Savani, M. Labopin, S. Piemontese, E. Polge et al., Impact of conditioning intensity in T-replete haplo-identical stem cell transplantation for acute leukemia: a report from the acute leukemia working party of the EBMT, Journal of Hematology & Oncology, vol.69, issue.2, p.25, 2016.
DOI : 10.1016/0002-9343(80)90380-0
URL : https://hal.archives-ouvertes.fr/hal-01297485

S. Piemontese, F. Ciceri, M. Labopin, W. Arcese, S. Kyrcz-krzemien et al., A comparison between allogeneic stem cell transplantation from unmanipulated haploidentical and unrelated donors in acute leukemia, Journal of Hematology & Oncology, vol.33, issue.9, p.24, 2017.
DOI : 10.3324/haematol.2016.151779
URL : https://hal.archives-ouvertes.fr/hal-01501594

Y. Chang, L. Luznik, E. Fuchs, and X. Huang, How do we choose the best donor for T-cell-replete, HLA-haploidentical transplantation?, Journal of Hematology & Oncology, vol.121, issue.20, p.35, 2016.
DOI : 10.1182/blood-2012-11-468348
URL : http://doi.org/10.1186/s13045-016-0265-2

F. Baron, A. Ruggeri, and A. Nagler, expansion of human cord blood cells: challenges, successes and clinical implications, Expert Review of Hematology, vol.9, issue.3, pp.297-314, 2016.
DOI : 10.1586/17474086.2016.1128321