Gaining Insights Into Multiple Sclerosis Lesion Characteristics from Brain Tissue Microstructure Information: A Multi-Compartment T2 Relaxometry Approach - Archive ouverte HAL Access content directly
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Gaining Insights Into Multiple Sclerosis Lesion Characteristics from Brain Tissue Microstructure Information: A Multi-Compartment T2 Relaxometry Approach

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Abstract

Clinical trends and pathogenetic ways of onset and progression of Multiple Sclerosis (MS) in patients suggest that MS is a highly heterogeneous disease. MS is predominantly a White Matter (WM) disease, which is mainly composed of myelinated axons and neuroglia type cells. Demyelination and axonal loss characterize the condition of MS in a patient. However, they follow varying trends in patients. In this work, we propose a method in which T2 relaxometry data is used to obtain a quantitative brain tissue microstructure information. This information is then studied to check its corroborations with pathogenetic understanding of MS in literature.
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Dates and versions

inserm-01543061 , version 1 (20-06-2017)

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  • HAL Id : inserm-01543061 , version 1

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Sudhanya Chatterjee, Olivier Commowick, Simon K. Warfield, Christian Barillot. Gaining Insights Into Multiple Sclerosis Lesion Characteristics from Brain Tissue Microstructure Information: A Multi-Compartment T2 Relaxometry Approach. ISMRM 25TH ANNUAL MEETING & EXHIBITION, Apr 2017, Honolulu, Hawaii, USA, United States. ⟨inserm-01543061⟩
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