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Argan oil prevents down-regulation induced by endotoxin on liver fatty acid oxidation and gluconeogenesis and on peroxisome proliferator-activated receptor gamma coactivator-1 alpha, (PGC-1alpha), peroxisome proliferator-activated receptor gamma (PPARgamma) and estrogen related receptor alpha (ERRalpha)

Abstract : In patients with sepsis, liver metabolism and its capacity to provide other organs with energetic substrates are impaired. This and many other pathophysiological changes seen in human patients are reproduced in mice injected with purified endotoxin (lipopolysaccharide, LPS). In the present study, down-regulation of genes involved in hepatic fatty acid oxidation (FAOx) and gluconeogenesis in mice exposed to LPS was challenged by nutritional intervention with argan oil. Mice given a standard chow supplemented or not with either 6% (w/w) argan oil (AO) or 6% (w/w) olive oil (OO) prior to exposure to LPS were explored for liver gene expressions and enzyme activities. LPS-treated mice were protected by nutritional AO or OO supplementations against down-regulations of hepatic FAOx and gluconeogenesis. Underlying mechanisms lied in a prevention of sepsis-associated drops in hepatic expressions of nuclear receptors PPARα and ERRα and coactivator PGC-1α. These preventive mechanisms conveyed by AO against LPS-induced metabolic dysregulation might add new therapeutic potentialities in the management of human sepsis.
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Riad Kebbaj, Pierre Andreoletti, Hammam El Hajj, Youssef El Kharrassi, Joseph Vamecq, et al.. Argan oil prevents down-regulation induced by endotoxin on liver fatty acid oxidation and gluconeogenesis and on peroxisome proliferator-activated receptor gamma coactivator-1 alpha, (PGC-1alpha), peroxisome proliferator-activated receptor gamma (PPARgamma) and estrogen related receptor alpha (ERRalpha). Biochimie Open, Elsevier, 2015, 1, pp.51-59. ⟨10.1016/j.biopen.2015.10.002⟩. ⟨inserm-01534672⟩

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