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Journal articles
Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages.
Catherine Sabatel
1, 2
Coraline Radermecker
1, 2
Laurence Fievez
1
Genevieve Paulissen
1
Svetoslav Chakarov
3
Claudia Fernandes
1
Sabine Olivier
1
Marie Toussaint
4
Dimitri Pirottin
1, 2
Xue Xiao
2, 5
Pascale Quatresooz
6
Jean-Claude Sirard
7
Didier Cataldo
1
Laurent Gillet
2, 5
Hicham Bouabe
8
Christophe J Desmet
1
Florent Ginhoux
3
Thomas Marichal
1, 2, *
Fabrice Bureau
9, 1, 2
*
Corresponding author
5
FARAH - Fundamental and Applied Research for Animals & Health
Faculté de Médecine Vétérinaire [Liège]
Catherine Sabatel 1, 2
Author
Coraline Radermecker 1, 2
Author
Laurence Fievez 1
Author
Genevieve Paulissen 1
Author
Svetoslav Chakarov 3
Author
Claudia Fernandes 1
Author
Sabine Olivier 1
Author
Marie Toussaint 4
Author
Dimitri Pirottin 1, 2
Author
Xue Xiao 2, 5
Author
Pascale Quatresooz 6
Author
Jean-Claude Sirard 7
Author IdHAL : jean-claude-sirard ResearcherId : http://www.researcherid.com/rid/B-5932-2011 IdRef : https://www.idref.fr/124317901 ORCID : https://orcid.org/0000-0001-9854-4652
Didier Cataldo 1
Author
Laurent Gillet 2, 5
Author
Hicham Bouabe 8
Author
Christophe J Desmet 1
Author
1
GIGA-Research - Groupe Interdisciplinaire de Génoprotéomique Appliquée (Avenue de l'Hôpital 1, 4000 Sart-Tilman - Belgium)
- Université de Liège (Place du 20-Août, 7 4000 Liège - Belgium)
2
Faculté de Médecine Vétérinaire [Liège] (
Faculté de Médecine Vétérinaire
Bâtiment B42
Quartier Vallée 2
Avenue de Cureghem 7A-7D
4000 Liège - Belgium)
3
SIgN - Singapore Immunology Network ( Agency for Science, Technology and Research (A*STAR) - 8A Biomedical Grove, Immunos Building, Level 4
Singapore 138648 - Singapore)
- BMSI - Biomedical Sciences Institute (20 Biopolis Way, Singapore 138668 - Singapore)
4
NHLI - National Heart and Lung Institute [London, UK] (Faculty of Medicine - Imperial College London.
Guy Scadding Building,
Cale Street, London, SW3 6LY - United Kingdom)
- Imperial College London (South Kensington Campus, London SW7 2AZ - United Kingdom)
5
FARAH - Fundamental and Applied Research for Animals & Health (Bâtiment B42 - Quartier Vallée 2,
Avenue de Cureghem 7A-7D,
4000 Liège (Belgique) - Belgium)
- Faculté de Médecine Vétérinaire [Liège] ( Faculté de Médecine Vétérinaire Bâtiment B42 Quartier Vallée 2 Avenue de Cureghem 7A-7D 4000 Liège - Belgium)
6
CRPP - Centre de recherche sur les protéines prions [Liège, Belgique] (Prion Proteins Resaerch Center - Faculté de médecine de Liège - Belgium)
- Université de Liège (Place du 20-Août, 7 4000 Liège - Belgium)
7
CIIL - Centre d’Infection et d’Immunité de Lille - INSERM U1019 - UMR 9017 (1 Rue du Professeur Calmette - Lille Cedex - 59019 - BP 245 - France)
- Institut Pasteur de Lille : UMR8204 (1 Rue du Professeur Calmette - Lille Cedex - 59019 - France)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR9017 (France)
- CHRU Lille - Centre Hospitalier Régional Universitaire [Lille] : U1019 (2, avenue Oscar Lambret - 59037 Lille Cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1019 (101, rue de Tolbiac, 75013 Paris - France)
- Université de Lille : UMR9017 (Lille - France)
8
The Babraham Institute [Cambridge, UK] (Babraham Hall, Babraham, Cambridge CB22 3AT - United Kingdom)
9
WELBIO - Walloon Excellence in Life sciences and BIOtechnology [Liège] (Avenue de l'Hôpital, 1
4000 Liège - Belgium)
Abstract : Living in a microbe-rich environment reduces the risk of developing asthma. Exposure of humans or mice to unmethylated CpG DNA (CpG) from bacteria reproduces these protective effects, suggesting a major contribution of CpG to microbe-induced asthma resistance. However, how CpG confers protection remains elusive. We found that exposure to CpG expanded regulatory lung interstitial macrophages (IMs) from monocytes infiltrating the lung or mobilized from the spleen. Trafficking of IM precursors to the lung was independent of CCR2, a chemokine receptor required for monocyte mobilization from the bone marrow. Using a mouse model of allergic airway inflammation, we found that adoptive transfer of IMs isolated from CpG-treated mice recapitulated the protective effects of CpG when administered before allergen sensitization or challenge. IM-mediated protection was dependent on IL-10, given that Il10(-/-) CpG-induced IMs lacked regulatory effects. Thus, the expansion of regulatory lung IMs upon exposure to CpG might underlie the reduced risk of asthma development associated with a microbe-rich environment.
Document type :
Journal articles
Domain :
Complete list of metadatas
https://www.hal.inserm.fr/inserm-01529380
Contributor : Jean-Claude Sirard <>
Submitted on : Tuesday, May 30, 2017 - 4:45:00 PM
Last modification on : Monday, December 14, 2020 - 11:06:04 AM
Contributor : Jean-Claude Sirard <>
Submitted on : Tuesday, May 30, 2017 - 4:45:00 PM
Last modification on : Monday, December 14, 2020 - 11:06:04 AM
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Identifiers
- HAL Id : inserm-01529380, version 1
- DOI : 10.1016/j.immuni.2017.02.016
- PUBMED : 28329706
Collections
INSERM | CNRS | RIIP_LILLE | RIIP | UNIV-LILLE | CIIL
Citation
Catherine Sabatel, Coraline Radermecker, Laurence Fievez, Genevieve Paulissen, Svetoslav Chakarov, et al.. Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages.. Immunity, Elsevier, 2017, 46 (3), pp.457-473. ⟨10.1016/j.immuni.2017.02.016⟩. ⟨inserm-01529380⟩
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