Skip to Main content Skip to Navigation
Journal articles

Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages.

Abstract : Living in a microbe-rich environment reduces the risk of developing asthma. Exposure of humans or mice to unmethylated CpG DNA (CpG) from bacteria reproduces these protective effects, suggesting a major contribution of CpG to microbe-induced asthma resistance. However, how CpG confers protection remains elusive. We found that exposure to CpG expanded regulatory lung interstitial macrophages (IMs) from monocytes infiltrating the lung or mobilized from the spleen. Trafficking of IM precursors to the lung was independent of CCR2, a chemokine receptor required for monocyte mobilization from the bone marrow. Using a mouse model of allergic airway inflammation, we found that adoptive transfer of IMs isolated from CpG-treated mice recapitulated the protective effects of CpG when administered before allergen sensitization or challenge. IM-mediated protection was dependent on IL-10, given that Il10(-/-) CpG-induced IMs lacked regulatory effects. Thus, the expansion of regulatory lung IMs upon exposure to CpG might underlie the reduced risk of asthma development associated with a microbe-rich environment.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-01529380
Contributor : Jean-Claude Sirard <>
Submitted on : Tuesday, May 30, 2017 - 4:45:00 PM
Last modification on : Thursday, April 9, 2020 - 1:47:18 AM

Links full text

Identifiers

Collections

Citation

Catherine Sabatel, Coraline Radermecker, Laurence Fievez, Genevieve Paulissen, Svetoslav Chakarov, et al.. Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages.. Immunity, Elsevier, 2017, 46 (3), pp.457-473. ⟨10.1016/j.immuni.2017.02.016⟩. ⟨inserm-01529380⟩

Share

Metrics

Record views

725