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Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner.

Abstract : Lactate is an essential component of carbon metabolism in mammals. Recently, lactate was shown to signal through the G protein coupled receptor 81 (GPR81) and to thus modulate inflammatory processes. This study demonstrates that lactate inhibits pro-inflammatory signaling in a GPR81-independent fashion. While lipopolysaccharide (LPS) triggered expression of IL-6 and IL-12 p40, and CD40 in bone marrow-derived macrophages, lactate was able to abrogate these responses in a dose dependent manner in Gpr81-/- cells as well as in wild type cells. Macrophage activation was impaired when glycolysis was blocked by chemical inhibitors. Remarkably, lactate was found to inhibit LPS-induced glycolysis in wild type as well as in Gpr81-/- cells. In conclusion, our study suggests that lactate can induce GPR81-independent metabolic changes that modulate macrophage pro-inflammatory activation.
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https://www.hal.inserm.fr/inserm-01529298
Contributor : Jean-Claude Sirard <>
Submitted on : Tuesday, May 30, 2017 - 2:57:27 PM
Last modification on : Thursday, April 9, 2020 - 1:47:38 AM

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Agustina Errea, Delphine Cayet, Philippe Marchetti, Cong Tang, Jerome Kluza, et al.. Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner.. PLoS ONE, Public Library of Science, 2016, 11 (11), pp.e0163694. ⟨10.1371/journal.pone.0163694⟩. ⟨inserm-01529298⟩

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