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Sublingual flagellin protects against acute pneumococcal pneumonia in a TLR5-dependent and NLRC4-independent fashion.

Résumé : AIM: To evaluate efficacy of sublingual flagellin to treat acute pneumonia. MATERIALS & METHODS: Mice were treated sublingually with flagellin and challenged intranasally with a lethal dose of pneumococcus. Flagellins lacking TLR5 or NLRC4 activation domains were used to assess their contribution to protection. RESULTS: Sublingual flagellin protected mice in a TLR5-dependent, NLRC4-independent fashion. Neutrophils were required for protection. Flagellin-stimulated lung epithelial cells recapitulated the lung's transcriptional profile suggesting they could be targeted by flagellin in vivo. CONCLUSION: Ligation of TLR5, a pathogen recognition receptor not naturally engaged by pneumococcus, protects mice from invasive pneumonia when administered via sublingual route. This can be a highly cost-effective alternative therapy against pneumonia.
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https://www.hal.inserm.fr/inserm-01529275
Contributor : Jean-Claude Sirard <>
Submitted on : Tuesday, May 30, 2017 - 2:38:41 PM
Last modification on : Wednesday, September 30, 2020 - 4:28:02 PM

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Natalia Muñoz-Wolf, Analía Rial, Delphine Fougeron, Julien Tabareau, Jean-Claude Sirard, et al.. Sublingual flagellin protects against acute pneumococcal pneumonia in a TLR5-dependent and NLRC4-independent fashion.. Future Microbiology, Future Medicine, 2016, 11 (9), pp.1167-77. ⟨10.2217/fmb-2016-0045⟩. ⟨inserm-01529275⟩

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