Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer's disease in older adults

Catherine Feart 1, * Catherine Helmer 1 Bénédicte Merle 1 François Herrmann 2 Cédric Annweiler 3, 4 Jean François Dartigues 1 Cecile Delcourt 1 Cecilia Samieri 1
* Auteur correspondant
1 BPH - Bordeaux population health
2 Department of Rehabilitation and Geriatrics [Geneva, Switzerland]
3 Robarts Research Institute [Canada]
4 Pôle de Neurosciences - Service de Gériatrie [Angers]
Abstract : INTRODUCTION: Hypovitaminosis D has been associated with several chronic conditions; yet, its association with cognitive decline and the risk of dementia and Alzheimer's disease (AD) has been inconsistent. METHODS: The study population consisted of 916 participants from the Three-City Bordeaux cohort aged 65+, nondemented at baseline, with assessment of vitamin D status and who were followed for up to 12 years. RESULTS: In multivariate analysis, compared with individuals with 25(OH)D sufficiency (n = 151), participants with 25(OH)D deficiency (n = 218) exhibited a faster cognitive decline. A total of 177 dementia cases (124 AD) occurred: 25(OH)D deficiency was associated with a nearly three-fold increased risk of AD (hazard ratio = 2.85, 95% confidence interval 1.37-5.97). DISCUSSION: This large prospective study of French older adults suggests that maintaining adequate vitamin D status in older age could contribute to slow down cognitive decline and to delay or prevent the onset of dementia, especially of AD etiology.
Keywords : Cognitive decline Dementia Prospective studies Risk factors in epidemiology Vitamin D Alzheimer's disease
Type de document :
Article dans une revue
Alzheimer's and Dementia, Elsevier, 2017, Epub ahead of print. 〈10.1016/j.jalz.2017.03.003〉
Liste complète des métadonnées
http://www.hal.inserm.fr/inserm-01527349
Contributeur : Christine Dupuis <>
Soumis le : mercredi 24 mai 2017 - 12:06:44
Dernière modification le : lundi 5 février 2018 - 15:00:10
Document(s) archivé(s) le : lundi 28 août 2017 - 17:04:32

Fichier

VitD_Dementia_Alz_Dem_2017 HAL...
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

UNIV-ANGERS | UNAM

Citation

Catherine Feart, Catherine Helmer, Bénédicte Merle, François Herrmann, Cédric Annweiler, et al.. Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer's disease in older adults. Alzheimer's and Dementia, Elsevier, 2017, Epub ahead of print. 〈10.1016/j.jalz.2017.03.003〉. 〈inserm-01527349〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

429

Téléchargements de fichiers

168

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD