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Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer's disease in older adults

Abstract : INTRODUCTION: Hypovitaminosis D has been associated with several chronic conditions; yet, its association with cognitive decline and the risk of dementia and Alzheimer's disease (AD) has been inconsistent. METHODS: The study population consisted of 916 participants from the Three-City Bordeaux cohort aged 65+, nondemented at baseline, with assessment of vitamin D status and who were followed for up to 12 years. RESULTS: In multivariate analysis, compared with individuals with 25(OH)D sufficiency (n = 151), participants with 25(OH)D deficiency (n = 218) exhibited a faster cognitive decline. A total of 177 dementia cases (124 AD) occurred: 25(OH)D deficiency was associated with a nearly three-fold increased risk of AD (hazard ratio = 2.85, 95% confidence interval 1.37-5.97). DISCUSSION: This large prospective study of French older adults suggests that maintaining adequate vitamin D status in older age could contribute to slow down cognitive decline and to delay or prevent the onset of dementia, especially of AD etiology.
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https://www.hal.inserm.fr/inserm-01527349
Contributor : Christine Dupuis <>
Submitted on : Wednesday, May 24, 2017 - 12:06:44 PM
Last modification on : Monday, August 24, 2020 - 3:02:02 PM
Long-term archiving on: : Monday, August 28, 2017 - 5:04:32 PM

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Catherine Feart, Catherine Helmer, Bénédicte Merle, François Herrmann, Cédric Annweiler, et al.. Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer's disease in older adults. Alzheimer's and Dementia, Elsevier, 2017, Epub ahead of print. ⟨10.1016/j.jalz.2017.03.003⟩. ⟨inserm-01527349⟩

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