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Journal articles
Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer's disease in older adults
Abstract : INTRODUCTION:
Hypovitaminosis D has been associated with several chronic conditions; yet, its association with cognitive decline and the risk of dementia and Alzheimer's disease (AD) has been inconsistent.
METHODS:
The study population consisted of 916 participants from the Three-City Bordeaux cohort aged 65+, nondemented at baseline, with assessment of vitamin D status and who were followed for up to 12 years.
RESULTS:
In multivariate analysis, compared with individuals with 25(OH)D sufficiency (n = 151), participants with 25(OH)D deficiency (n = 218) exhibited a faster cognitive decline. A total of 177 dementia cases (124 AD) occurred: 25(OH)D deficiency was associated with a nearly three-fold increased risk of AD (hazard ratio = 2.85, 95% confidence interval 1.37-5.97).
DISCUSSION:
This large prospective study of French older adults suggests that maintaining adequate vitamin D status in older age could contribute to slow down cognitive decline and to delay or prevent the onset of dementia, especially of AD etiology.
https://www.hal.inserm.fr/inserm-01527349
Contributor : Christine Dupuis Connect in order to contact the contributor
Submitted on : Wednesday, May 24, 2017 - 12:06:44 PM
Last modification on : Wednesday, November 3, 2021 - 4:37:19 AM
Long-term archiving on: : Monday, August 28, 2017 - 5:04:32 PM
Contributor : Christine Dupuis Connect in order to contact the contributor
Submitted on : Wednesday, May 24, 2017 - 12:06:44 PM
Last modification on : Wednesday, November 3, 2021 - 4:37:19 AM
Long-term archiving on: : Monday, August 28, 2017 - 5:04:32 PM
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