A. Ma, R. Koka, and P. Burkett, DIVERSE FUNCTIONS OF IL-2, IL-15, AND IL-7 IN LYMPHOID HOMEOSTASIS, Annual Review of Immunology, vol.24, issue.1, pp.657-679, 2006.
DOI : 10.1146/annurev.immunol.24.021605.090727

J. P. Siegel and R. K. Puri, Interleukin-2 toxicity., Journal of Clinical Oncology, vol.9, issue.4, pp.694-704, 1991.
DOI : 10.1200/JCO.1991.9.4.694

S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, and M. Toda, Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25) Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases, J. Immunol, vol.155, pp.1151-1164, 1995.

D. Klatzmann and A. K. Abbas, The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases, Nature Reviews Immunology, vol.134, issue.5, pp.283-294, 2015.
DOI : 10.1016/S0140-6736(00)02799-9

J. P. Lodolce, D. L. Boone, S. Chai, R. E. Swain, T. Dassopoulos et al., IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation, Immunity, vol.9, issue.5, pp.669-676, 1998.
DOI : 10.1016/S1074-7613(00)80664-0

URL : http://doi.org/10.1016/s1074-7613(00)80664-0

M. K. Kennedy, M. Glaccum, S. N. Brown, E. A. Butz, J. L. Viney et al., Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15???Deficient Mice, The Journal of Experimental Medicine, vol.10, issue.5, pp.771-780, 2000.
DOI : 10.1093/intimm/9.9.1367

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195858/pdf

K. H. Grabstein, J. Eisenman, K. Shanebeck, C. Rauch, S. Srinivasan et al., Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor, Science, vol.264, issue.5161, pp.965-968, 1994.
DOI : 10.1126/science.8178155

T. A. Waldmann and Y. Tagaya, THE MULTIFACETED REGULATION OF INTERLEUKIN-15 EXPRESSION AND THE ROLE OF THIS CYTOKINE IN NK CELL DIFFERENTIATION AND HOST RESPONSE TO INTRACELLULAR PATHOGENS, Annual Review of Immunology, vol.17, issue.1, pp.19-49, 1999.
DOI : 10.1146/annurev.immunol.17.1.19

S. Dubois, J. Mariner, T. A. Waldmann, and Y. Tagaya, IL-15R?? Recycles and Presents IL-15 In trans to Neighboring Cells, Immunity, vol.17, issue.5, pp.537-547, 2002.
DOI : 10.1016/S1074-7613(02)00429-6

URL : http://doi.org/10.1016/s1074-7613(02)00429-6

T. A. Waldmann, The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design, Nature Reviews Immunology, vol.153, issue.8, pp.595-601, 2006.
DOI : 10.1038/nri1901

N. L. Farner, J. Gan, J. L. De-jong, T. P. Leary, T. S. Fenske et al., ALTERATION OF THE CD34+Tf-1?? CELL LINE PROFILE IN RESPONSE TO LONG-TERM EXPOSURE TO IL-15, Cytokine, vol.9, issue.5, pp.316-327, 1997.
DOI : 10.1006/cyto.1996.0171

F. Tamzalit, I. Barbieux, A. Plet, J. Heim, S. Nedellec et al., IL-15.IL-15Ra complex shedding following transpresentation is essential for the survival of IL-15 responding NK and T cells, Proc. Natl. Acad. Sci. USA, pp.8565-8570, 2014.

Y. Jacques, B. L. Mauff, A. Godard, D. Olive, J. F. Moreau et al., Regulation of interleukin 2 receptor expression on a human cytotoxic T lymphocyte clone, synergism between alloantigenic stimulation and interleukin 2, J. Immunol, vol.136, pp.1693-1699, 1986.

A. M. Ring, J. X. Lin, D. Feng, S. Mitra, M. Rickert et al., Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15, Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15, pp.1187-1195, 2012.
DOI : 10.1038/nprot.2009.236

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501574

G. Bouchaud, L. Garrigue-antar, V. Solé, A. Quéméner, Y. Boublik et al., 230 The exon 3-encoded domain of IL-15Ralpha contributes to IL-15 high-affinity binding and is crucial for IL-15 antagonistic effect of soluble IL-15Ralpha, Cytokine, vol.43, issue.3, pp.1-12, 2008.
DOI : 10.1016/j.cyto.2008.07.294

E. Mortier, A. Quéméner, P. Vusio, I. Lorenzen, Y. Boublik et al., Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma, 2006.

S. Mitra, A. M. Ring, S. Amarnath, J. B. Spangler, P. Li et al., Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps, Immunity, vol.42, issue.5, pp.826-838, 2015.
DOI : 10.1016/j.immuni.2015.04.018

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560365

D. K. Pettit, T. P. Bonnert, J. Eisenman, S. Srinivasan, R. Paxton et al., Structure-function studies of interleukin 15 using site-specific mutagenesis, polyethylene glycol conjugation, and homology modeling, J. Biol. Chem, vol.272, pp.2312-2318, 1997.

J. Bernard, C. Harb, E. Mortier, A. Quéméner, R. H. Meloen et al., Identification of an interleukin-15a receptor-binding site on human interleukin-15, 2004.

S. Damjanovich, L. Bene, J. Matkó, A. Alileche, C. K. Goldman et al., Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: A fluorescence resonance energy transfer study, Proc. Natl. Acad. Sci. USA, pp.13134-13139, 1997.
DOI : 10.1016/0955-0674(95)80113-8

M. Tsudo, F. Kitamura, and M. Miyasaka, Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies., Proc. Natl. Acad. Sci. USA, pp.1982-1986, 1989.
DOI : 10.1073/pnas.86.6.1982

C. Francois, F. Boeffard, B. Kaluza, U. H. Weidle, and Y. Jacques, Construction of a bispecific antibody reacting with the alpha-and beta-chains of the human IL-2 receptor. High affinity cross-linking and high anti-proliferative efficiency, J. Immunol, vol.150, pp.4610-4619, 1993.

H. Perdreau, E. Mortier, G. Bouchaud, V. Solé, Y. Boublik et al., Different dynamics of IL-15R activation following IL-15 cisor trans-presentation, Eur. Cytokine Netw, vol.21, pp.297-307, 2010.

A. Hémar, A. Subtil, M. Lieb, E. Morelon, R. Hellio et al., Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor alpha, beta, and gamma chains, The Journal of Cell Biology, vol.129, issue.1, pp.55-64, 1995.
DOI : 10.1083/jcb.129.1.55

E. Mortier, T. Woo, R. Advincula, S. Gozalo, and A. Ma, IL-15R?? chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation, The Journal of Experimental Medicine, vol.161, issue.5, pp.1213-1225, 2008.
DOI : 10.1016/S1074-7613(02)00365-5

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373851

G. Gasteiger, S. Hemmers, M. A. Firth, A. Le-floc-'h, M. Huse et al., IL-2???dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells, The Journal of Experimental Medicine, vol.153, issue.6, pp.1167-1178, 2013.
DOI : 10.1016/j.ccr.2009.05.018