Cerebral and muscle microvascular oxygenation in children with sickle cell disease: Influence of hematology, hemorheology and vasomotion.

Keyne Charlot; Sophie Antoine-Jonville; Berenike Moeckesch; Stéphane Jumet; Marc Romana; Xavier Waltz; Lydia Divialle-Doumdo; Marie Hardy-Dessources; Marie Petras; Benoît Tressieres; Vanessa Tarer; Olivier Hue; Maryse Etienne-Julan; Philippe Connes

doi:10.1016/j.bcmd.2017.03.015

Cerebral and muscle microvascular oxygenation in children with sickle cell disease: Influence of hematology, hemorheology and vasomotion.

Keyne Charlot ^{1, 2, 3} Sophie Antoine-Jonville ² Berenike Moeckesch ^{1, 2} Stéphane Jumet ² Marc Romana ¹ Xavier Waltz ^{1, 2} Lydia Divialle-Doumdo ⁴ Marie Hardy-Dessources ¹ Marie Petras ⁴ Benoît Tressieres ⁵ Vanessa Tarer ⁴ Olivier Hue ² Maryse Etienne-Julan ⁴ Philippe Connes ^{6, 1, 7, *}

* Auteur correspondant

1 BIGR - Biologie Intégrée du Globule Rouge

2 ACTES - Adaptation, Climat Tropical, Exercice et Santé

3 IRBA - Institut de Recherche Biomédicale des Armées

4 Unité Transversale de la Drépanocytose

5 CIC - Antilles Guyane - Centre d'Investigation Clinique Antilles-Guyane

6 IUF - Institut Universitaire de France

7 LIBM - Laboratoire Interuniversitaire de Biologie de la Motricité

Abstract : The present study investigated cerebral and muscle hemoglobin oxygen saturation (tissue oxygen index, TOI) in children with sickle cell anemia (SS), sickle cell hemoglobin C disease (SC) and healthy children (AA). TOI was measured by near-infrared spectroscopy (NIRS) and spectral analysis of the TOI variability was used to assess flowmotion and vasomotion. Arterial oxyhemoglobin saturation (SpO2), hemorheological and hematological parameters were also measured in SS and SC children. Both TOI were lower in SS compared to both AA and SC children, with SC exhibiting lower values than AA children. Cerebral vasomotion expressed in absolute values was enhanced in SS compared to AA and SC children. Muscle vasomotion did not differ between the three groups. Hematocrit, SpO2 and red blood cell deformability were positively associated with cerebral TOI in SS children. We demonstrated that 1) cerebral and muscle TOI were markedly decreased in SS children while the decrease of TOI was milder in SC children, 2) cerebral TOI level was associated with several biological markers in SS children only and 3) cerebral vasomotion was enhanced in SS, possibly to counterbalance the effects of chronic cerebral hypoxia.

Keywords : Tissue oxygen index Vasomotion Near-infrared spectroscopy Sickle cell disease

Type de document :

Article dans une revue

Blood Cells, Molecules and Diseases, Elsevier, 2017, 65, pp.23-28. 〈10.1016/j.bcmd.2017.03.015〉

Domaine :

Sciences du Vivant [q-bio] / Santé publique et épidémiologie

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Cerebral and muscle microvascular oxygenation in children with sickle cell disease: Influence of hematology, hemorheology and vasomotion.

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Cerebral and muscle microvascular oxygenation in children with sickle cell disease: Influence of hematology, hemorheology and vasomotion.

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