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Journal articles
Cerebral and muscle microvascular oxygenation in children with sickle cell disease: Influence of hematology, hemorheology and vasomotion.
Keyne Charlot
1, 2, 3
Sophie Antoine-Jonville
2
Berenike Moeckesch
1, 2
Stéphane Jumet
2
Marc Romana
1
Xavier Waltz
1, 2
Lydia Divialle-Doumdo
4
Marie Hardy-Dessources
1
Marie Petras
4
Benoît Tressieres
5
Vanessa Tarer
4
Olivier Hue
2
Maryse Etienne-Julan
4
Philippe Connes
6, 1, 7, *
*
Corresponding author
Keyne Charlot 1, 2, 3
Author
Sophie Antoine-Jonville 2
Author IdHAL : sophie-antoine-jonville ORCID : https://orcid.org/0000-0003-0691-2177
Berenike Moeckesch 1, 2
Author
Stéphane Jumet 2
Author
Marc Romana 1
Author IdHAL : marc-romana ORCID : https://orcid.org/0000-0002-8715-9836
Xavier Waltz 1, 2
Author
Lydia Divialle-Doumdo 4
Author
Marie Hardy-Dessources 1
Author
Marie Petras 4
Author
Benoît Tressieres 5
Author IdHAL : benoit-tressieres ORCID : https://orcid.org/0000-0002-9585-4281
Vanessa Tarer 4
Author
Olivier Hue 2
Author
Maryse Etienne-Julan 4
Author
Philippe Connes 6, 1, 7
Correspondent author IdHAL : philippe-connes ORCID : https://orcid.org/0000-0002-9232-0268
1
BIGR (UMR_S_1134 / U1134) - Biologie Intégrée du Globule Rouge (6 rue Alexandre Cabanel - 75739 Paris cedex 15 - France)
- INTS - Institut National de la Transfusion Sanguine [Paris] (6 rue Alexandre Cabanel, 75739 Paris cedex 15 - France)
- UPD7 - Université Paris Diderot - Paris 7 : UMR_S_1134 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)
- UR - Université de La Réunion (15, avenue René Cassin - CS92003 -97744 Saint Denis Cedex 9 - Réunion)
- UA - Université des Antilles (Université des Antilles | Fouillole - BP 250 - 97157 Pointe-à-Pitre - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1134 (101, rue de Tolbiac, 75013 Paris - France)
2
ACTES - Adaptation, Climat Tropical, Exercice et Santé (UFR STAPS - Campus de Fouillole - BP 592 - 97157 Pointe-à-Pitre Cedex - France)
- UA - Université des Antilles : EA 3596 (Université des Antilles | Fouillole - BP 250 - 97157 Pointe-à-Pitre - France)
3
IRBA - Institut de Recherche Biomédicale des Armées (Brétigny-sur-Orge - France)
4
Unité Transversale de la Drépanocytose (BP 465 - 97159 Pointe-à-Pitre Cedex - Guadeloupe)
- Hôpital Ricou (France)
- CHU Pointe-à-Pitre/Abymes [Guadeloupe] (Route de Chauvel - BP 465 - 97159 Pointe-à-Pitre cedex - France)
5
CIC - Antilles Guyane - Centre d'Investigation Clinique Antilles-Guyane (Unité de Maladies infectieuses, génétiques, et émergentes - Av des flamboyants 97306 Cayenne - France)
- UAG - Université des Antilles et de la Guyane : EA3593 (Fouillole - BP 250 - 97157 Pointe-à-Pitre - Guadeloupe)
- INSERM - Institut National de la Santé et de la Recherche Médicale : CIC1424 (101, rue de Tolbiac, 75013 Paris - France)
- CHU Pointe-à-Pitre/Abymes [Guadeloupe] (Route de Chauvel - BP 465 - 97159 Pointe-à-Pitre cedex - France)
- CHU de Fort de France (France)
- Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] (Av des flamboyants, Cayenne 97306 - French Guiana)
6
IUF - Institut Universitaire de France (Maison des Universités 103 Boulevard Saint-Michel 75005 Paris - France)
- M.E.N.E.S.R. - Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (1 rue Descartes - 75231 Paris cedex 05 - France)
7
LIBM - Laboratoire Interuniversitaire de Biologie de la Motricité (CAMPUS SANTE INNOVATIONS - Bâtiment IRMIS - 10 rue de la Marandière 42270 Saint Priest en Jarez /
Université Savoie Mont Blanc - Campus Scientifique - 73370 Le Bourget du Lac / UFR STAPS - Université Claude Bernard Lyon I - 27/29 Boulevard du 11 novembre 1918 - 69622 Villeurbanne Cedex - France)
- USMB [Université de Savoie] [Université de Chambéry] - Université Savoie Mont Blanc : EA7424 (27, rue Marcoz - 73000 Chambéry - France)
- UCBL - Université Claude Bernard Lyon 1 : EA7424 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)
- Université de Lyon (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)
- UJM - Université Jean Monnet [Saint-Étienne] : EA7424 (10 rue Tréfilerie - 42100 Saint-Étienne - France)
Abstract : The present study investigated cerebral and muscle hemoglobin oxygen saturation (tissue oxygen index, TOI) in children with sickle cell anemia (SS), sickle cell hemoglobin C disease (SC) and healthy children (AA). TOI was measured by near-infrared spectroscopy (NIRS) and spectral analysis of the TOI variability was used to assess flowmotion and vasomotion. Arterial oxyhemoglobin saturation (SpO2), hemorheological and hematological parameters were also measured in SS and SC children. Both TOI were lower in SS compared to both AA and SC children, with SC exhibiting lower values than AA children. Cerebral vasomotion expressed in absolute values was enhanced in SS compared to AA and SC children. Muscle vasomotion did not differ between the three groups. Hematocrit, SpO2 and red blood cell deformability were positively associated with cerebral TOI in SS children. We demonstrated that 1) cerebral and muscle TOI were markedly decreased in SS children while the decrease of TOI was milder in SC children, 2) cerebral TOI level was associated with several biological markers in SS children only and 3) cerebral vasomotion was enhanced in SS, possibly to counterbalance the effects of chronic cerebral hypoxia.
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Journal articles
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https://www.hal.inserm.fr/inserm-01519106
Contributor : Inserm Cic1424 Centre d'Investigation Clinique Antilles Guyane <>
Submitted on : Friday, May 5, 2017 - 5:40:51 PM
Last modification on : Saturday, March 27, 2021 - 5:06:02 PM
Long-term archiving on: : Sunday, August 6, 2017 - 7:36:59 PM
Contributor : Inserm Cic1424 Centre d'Investigation Clinique Antilles Guyane <>
Submitted on : Friday, May 5, 2017 - 5:40:51 PM
Last modification on : Saturday, March 27, 2021 - 5:06:02 PM
Long-term archiving on: : Sunday, August 6, 2017 - 7:36:59 PM
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Identifiers
- HAL Id : inserm-01519106, version 1
- DOI : 10.1016/j.bcmd.2017.03.015
- PUBMED : 28411485
Collections
INSERM | UNIV-AG | UNIV-SAVOIE | UNIV-ST-ETIENNE | UNIV-LYON1 | ACTES | UNIV-PARIS7 | USPC | LIBM | UDL | UNIV-PARIS | UP-SCIENCES | AFRIQ | UGA
Citation
Keyne Charlot, Sophie Antoine-Jonville, Berenike Moeckesch, Stéphane Jumet, Marc Romana, et al.. Cerebral and muscle microvascular oxygenation in children with sickle cell disease: Influence of hematology, hemorheology and vasomotion.. Blood Cells, Molecules and Diseases, Elsevier, 2017, 65, pp.23-28. ⟨10.1016/j.bcmd.2017.03.015⟩. ⟨inserm-01519106⟩
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