I. N. Crispe, The Liver as a Lymphoid Organ, Annual Review of Immunology, vol.27, issue.1, pp.147-163, 2009.
DOI : 10.1146/annurev.immunol.021908.132629

I. N. Crispe, M. K. Maini, and P. A. Knolle, Liver antigen-presenting cells Living in the liver: Hepatic infections, J. Hepatol. Nat. Rev. Immunol, vol.54, issue.12, pp.357-365, 2011.

L. G. Guidotti and F. Chisari, IMMUNOBIOLOGY AND PATHOGENESIS OF VIRAL HEPATITIS, Annual Review of Pathology: Mechanisms of Disease, vol.1, issue.1, pp.23-61, 2006.
DOI : 10.1146/annurev.pathol.1.110304.100230

F. Heymann and F. Tacke, Immunology in the liver ??? from homeostasis to disease, Nature Reviews Gastroenterology & Hepatology, vol.61, issue.2, pp.88-110
DOI : 10.1038/nrgastro.2015.200

P. A. Knolle and R. Thimme, Hepatic Immune Regulation and Its Involvement in Viral Hepatitis Infection, Gastroenterology, vol.146, issue.5, pp.1193-1207
DOI : 10.1053/j.gastro.2013.12.036

I. N. Crispe, Immune tolerance in liver disease, Hepatology, vol.98, issue.6, pp.2109-2117, 2014.
DOI : 10.1002/hep.27254

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274953

A. Bertoletti and C. Ferrari, Adaptive immunity in HBV infection Immune responses to HCV and other hepatitis viruses, J. Hepatol. Immunity, vol.2016, issue.40, pp.13-24, 2014.

A. Bertoletti and C. Ferrari, Innate and adaptive immune responses in chronic hepatitis B virus infections: Towards restoration of immune control of viral infection, Gut, vol.2012, issue.61, pp.1754-1764

M. K. Maini and A. J. Gehring, The role of innate immunity in the immunopathology and treatment of HBV infection, S60?S70. [CrossRef]
DOI : 10.1016/j.jhep.2016.01.028

S. Pandey, T. Kawai, and S. Akira, Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid Sensors, Cold Spring Harbor Perspectives in Biology, vol.7, issue.1, 2014.
DOI : 10.1101/cshperspect.a016246

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292165

P. Broz and V. M. Dixit, Inflammasomes: mechanism of assembly, regulation and signalling, Nature Reviews Immunology, vol.7, issue.7, pp.407-420
DOI : 10.1038/nri.2016.58

S. M. Crowley, B. A. Vallance, and L. A. Knodler, Noncanonical inflammasomes: Antimicrobial defense that does not play by the rules, Cellular Microbiology, vol.352, issue.6290
DOI : 10.1038/mi.2016.77

I. N. Crispe, Hepatocytes as Immunological Agents, The Journal of Immunology, vol.196, issue.1, pp.17-21, 2016.
DOI : 10.4049/jimmunol.1501668

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685720

S. Luangsay, M. Ait-goughoulte, M. Michelet, O. Floriot, M. Bonnin et al., Expression and functionality of Toll- and RIG-like receptors in HepaRG cells, Journal of Hepatology, vol.63, issue.5, pp.1077-1085, 2015.
DOI : 10.1016/j.jhep.2015.06.022

S. Vegna, D. Gregoire, M. Moreau, P. Lassus, D. Durantel et al., ABSTRACT, Journal of Virology, vol.90, issue.13, pp.6022-6035, 2016.
DOI : 10.1128/JVI.03230-15

M. K. Thomsen, R. Nandakumar, D. Stadler, A. Malo, R. M. Valls et al., Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection, Hepatology, vol.24, issue.3, pp.746-759, 2016.
DOI : 10.1002/hep.28685

C. Zannetti, G. Roblot, E. Charrier, M. Ainouze, I. Tout et al., Characterization of the Inflammasome in Human Kupffer Cells in Response to Synthetic Agonists and Pathogens, The Journal of Immunology, vol.197, issue.1, pp.356-367, 2016.
DOI : 10.4049/jimmunol.1502301

P. Gripon, S. Rumin, S. Urban, J. Le-seyec, D. Glaise et al., Infection of a human hepatoma cell line by hepatitis B virus, Proc. Natl. Acad. Sci, pp.15655-15660, 2002.

M. A. Sells, M. L. Chen, and G. Acs, Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA., Proc. Natl. Acad. Sci, pp.1005-1009, 1987.
DOI : 10.1073/pnas.84.4.1005

S. K. Ladner, M. J. Otto, C. S. Barker, K. Zaifert, G. H. Wang et al., Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: A novel system for screening potential inhibitors of HBV replication, Antimicrob. Agents Chemother, vol.41, pp.1715-1720, 1997.

P. Gripon, C. Diot, N. Thézé, I. Fourel, O. Loreal et al., Hepatitis B virus infection of adult human hepatocytes cultured in the presence of dimethyl sulfoxide, J. Virol, vol.62, pp.4136-4143, 1988.

W. Li and S. Urban, Entry of hepatitis B and hepatitis D virus into hepatocytes: Basic insights and clinical implications, S32?S40. [CrossRef]
DOI : 10.1016/j.jhep.2016.02.011

M. Ait-goughoulte, R. Parent, and M. Rivoire, Early inhibition of hepatocyte innate responses by hepatitis B virus, J. Hepatol, vol.63, pp.1314-2132, 2015.

P. Vanlandschoot, F. Van-houtte, B. Serruys, and G. Leroux-roels, Contamination of a Recombinant Hepatitis B Virus Nucleocapsid Preparation with a Human B-Cell Activator, Journal of Virology, vol.81, issue.5, pp.2535-2536, 2007.
DOI : 10.1128/JVI.02507-06

A. Cooper, G. Tal, O. Lider, and Y. Shaul, Cytokine Induction by the Hepatitis B Virus Capsid in Macrophages Is Facilitated by Membrane Heparan Sulfate and Involves TLR2, The Journal of Immunology, vol.175, issue.5, pp.3165-3176, 2005.
DOI : 10.4049/jimmunol.175.5.3165

Z. Huang, J. Ge, J. Pang, H. Liu, J. Chen et al., Aberrant expression and dysfunction of TLR2 and its soluble form in chronic HBV infection and its regulation by antiviral therapy, Antiviral Research, vol.118, pp.10-19, 2015.
DOI : 10.1016/j.antiviral.2015.03.004

M. Yoneda, J. Hyun, S. Jakubski, S. Saito, A. Nakajima et al., Hepatitis B Virus and DNA Stimulation Trigger a Rapid Innate Immune Response through NF-??B, The Journal of Immunology, vol.197, issue.2, pp.630-643, 2016.
DOI : 10.4049/jimmunol.1502677

C. Seeger, F. Zoulim, W. S. Mason, and . Hepadnaviruses, In Field's Virology, p.2185, 2015.

S. Sato, K. Li, T. Kameyama, T. Hayashi, Y. Ishida et al., The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus, Immunity, vol.42, issue.1, pp.123-132, 2015.
DOI : 10.1016/j.immuni.2014.12.016

L. Riviere, L. Gerossier, A. Ducroux, S. Dion, Q. Deng et al., HBx relieves chromatin-mediated transcriptional repression of hepatitis B viral cccDNA involving SETDB1 histone methyltransferase, Journal of Hepatology, vol.63, issue.5, pp.1093-1102, 2015.
DOI : 10.1016/j.jhep.2015.06.023

A. Decorsiere, H. Mueller, P. C. Van-breugel, F. Abdul, L. Gerossier et al., Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor, Nature, vol.101, issue.7594, pp.386-389, 2016.
DOI : 10.1038/nature17170

P. Vanlandschoot, F. Van-houtte, A. Roobrouck, A. Farhoudi, F. Stelter et al., LPS-binding protein and CD14-dependent attachment of hepatitis B surface antigen to monocytes is determined by the phospholipid moiety of the particles, Journal of General Virology, vol.83, issue.9, pp.2279-2289, 2002.
DOI : 10.1099/0022-1317-83-9-2279

A. J. Gehring, M. Haniffa, P. T. Kennedy, Z. Z. Ho, C. Boni et al., Mobilizing monocytes to cross-present circulating viral antigen in chronic infection, Journal of Clinical Investigation, vol.123, issue.9, pp.3766-3776, 2013.
DOI : 10.1172/JCI66043DS1

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754243

N. Van-montfoort, E. Van-der-aa, A. Van-den-bosch, H. Brouwers, T. Vanwolleghem et al., ABSTRACT, Journal of Virology, vol.90, issue.14, pp.6187-6199, 2016.
DOI : 10.1128/JVI.02903-15

S. Wieland, R. Thimme, R. H. Purcell, and F. Chisari, Genomic analysis of the host response to hepatitis B virus infection, Proc. Natl. Acad. Sci, pp.6669-6674, 2004.
DOI : 10.1073/pnas.1730940100

A. R. Stacey, P. J. Norris, L. Qin, E. A. Haygreen, E. Taylor et al., Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus Infections, Journal of Virology, vol.83, issue.8, pp.3719-3733, 2009.
DOI : 10.1128/JVI.01844-08

C. Dunn, D. Peppa, P. Khanna, G. Nebbia, M. Jones et al., Temporal Analysis of Early Immune Responses in Patients With Acute Hepatitis B Virus Infection, Gastroenterology, vol.137, issue.4, pp.1289-1300, 2009.
DOI : 10.1053/j.gastro.2009.06.054

A. Das, G. Ellis, C. Pallant, A. R. Lopes, P. Khanna et al., IL-10-Producing Regulatory B Cells in the Pathogenesis of Chronic Hepatitis B Virus Infection, The Journal of Immunology, vol.189, issue.8, pp.3925-3935, 2012.
DOI : 10.4049/jimmunol.1103139

M. Hosel, M. Quasdorff, K. Wiegmann, D. Webb, U. Zedler et al., Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection, Hepatology, vol.77, issue.6, pp.1773-1782, 2009.
DOI : 10.1002/hep.23226

A. Shlomai, R. E. Schwartz, V. Ramanan, A. Bhatta, Y. P. De-jong et al., Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems, Proc. Natl. Acad. Sci. USA 2014, pp.12193-12198
DOI : 10.1002/hep.23361

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143014

F. Lebosse, B. Testoni, J. Fresquet, F. Facchetti, E. Galmozzi et al., Intrahepatic innate immune response pathways are downregulated in untreated chronic hepatitis B, Journal of Hepatology, vol.66, issue.5, pp.897-909, 2016.
DOI : 10.1016/j.jhep.2016.12.024

K. Visvanathan, N. A. Skinner, A. J. Thompson, S. M. Riordan, V. Sozzi et al., Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein, Hepatology, vol.38, issue.1, pp.102-110, 2007.
DOI : 10.1002/hep.21482

I. E. Vincent, C. Zannetti, J. Lucifora, H. Norder, U. Protzer et al., Hepatitis B Virus Impairs TLR9 Expression and Function in Plasmacytoid Dendritic Cells, PLoS ONE, vol.38, issue.Suppl 1, p.26315, 2011.
DOI : 10.1371/journal.pone.0026315.s003

URL : http://doi.org/10.1371/journal.pone.0026315

K. Giersch, L. Allweiss, T. Volz, M. Helbig, J. Bierwolf et al., Hepatitis Delta co-infection in humanized mice leads to pronounced induction of innate immune responses in comparison to HBV mono-infection, Journal of Hepatology, vol.63, issue.2, pp.346-353, 2015.
DOI : 10.1016/j.jhep.2015.03.011

D. Alfaiate, J. Lucifora, N. Abeywickrama-samarakoon, M. Michelet, B. Testoni et al., HDV RNA replication is associated with HBV repression and interferon-stimulated genes induction in super-infected hepatocytes, Antiviral Research, vol.136, pp.19-31, 2016.
DOI : 10.1016/j.antiviral.2016.10.006

J. Wu, Z. Meng, M. Jiang, R. Pei, M. Trippler et al., Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells, Hepatology, vol.34, issue.4, pp.1132-1140, 2009.
DOI : 10.1002/hep.22751

M. Gruffaz, B. Testoni, S. Luangsay, F. Fusil, A. G. Malika et al., The nuclear function of Hepatitis B capsid (HBc) protein is to inhibit IFN response very early after infection of hepatocytes, Hepatology, vol.58, p.276, 2013.

C. T. Bock, S. Schwinn, S. Locarnini, J. Fyfe, M. P. Manns et al., Structural organization of the hepatitis B virus minichromosome, Journal of Molecular Biology, vol.307, issue.1, pp.183-196, 2001.
DOI : 10.1006/jmbi.2000.4481

M. Fernandez, J. A. Quiroga, and V. Carreno, Hepatitis B virus downregulates the human interferon-inducible MxA promoter through direct interaction of precore/core proteins, Journal of General Virology, vol.84, issue.8, pp.2073-2082, 2003.
DOI : 10.1099/vir.0.18966-0

Y. H. Guo, Y. N. Li, J. R. Zhao, J. Zhang, and Z. Yan, HBc binds to the CpG islands of HBV cccDNA and promotes an epigenetic permissive state, Epigenetics, vol.6, issue.6, pp.720-726, 2011.
DOI : 10.4161/epi.6.6.15815

Z. Yi, J. Chen, M. Kozlowski, and Z. Yuan, Innate detection of hepatitis B and C virus and viral inhibition of the response, Cellular Microbiology, vol.35, issue.4, pp.1295-1303, 2015.
DOI : 10.1111/cmi.12489

M. Jiang, R. Broering, M. Trippler, L. Poggenpohl, M. Fiedler et al., Toll-like receptor-mediated immune responses are attenuated in the presence of high levels of hepatitis B virus surface antigen, Journal of Viral Hepatitis, vol.49, issue.4, pp.860-872, 2014.
DOI : 10.1111/jvh.12216

T. Lang, C. Lo, N. Skinner, S. Locarnini, K. Visvanathan et al., The Hepatitis B e antigen (HBeAg) targets and suppresses activation of the Toll-like receptor signaling pathway, Journal of Hepatology, vol.55, issue.4, pp.762-769, 2011.
DOI : 10.1016/j.jhep.2010.12.042

S. Wang, Z. Chen, C. Hu, F. Qian, Y. Cheng et al., Hepatitis B Virus Surface Antigen Selectively Inhibits TLR2 Ligand-Induced IL-12 Production in Monocytes/Macrophages by Interfering with JNK Activation, The Journal of Immunology, vol.190, issue.10, pp.5142-5151, 2013.
DOI : 10.4049/jimmunol.1201625

Y. Hong, L. Zhou, H. Xie, and S. Zheng, Innate immune evasion by hepatitis B virus-mediated downregulation of TRIF, Biochemical and Biophysical Research Communications, vol.463, issue.4, pp.719-725, 2015.
DOI : 10.1016/j.bbrc.2015.05.130

J. Jiang and H. Tang, Mechanism of inhibiting type I interferon induction by hepatitis B virus X protein, Protein & Cell, vol.18, issue.12, pp.1106-1117, 2010.
DOI : 10.1007/s13238-010-0141-8

M. Kumar, S. Y. Jung, A. J. Hodgson, C. R. Madden, J. Qin et al., Hepatitis B Virus Regulatory HBx Protein Binds to Adaptor Protein IPS-1 and Inhibits the Activation of Beta Interferon, Journal of Virology, vol.85, issue.2, pp.987-995, 2011.
DOI : 10.1128/JVI.01825-10

C. Wei, C. Ni, T. Song, Y. Liu, X. Yang et al., The Hepatitis B Virus X Protein Disrupts Innate Immunity by Downregulating Mitochondrial Antiviral Signaling Protein, The Journal of Immunology, vol.185, issue.2, pp.1158-1168, 2010.
DOI : 10.4049/jimmunol.0903874

B. L. Slagle, O. M. Andrisani, M. J. Bouchard, C. G. Lee, J. H. Ou et al., Technical standards for hepatitis B virus X protein (HBx) research, Hepatology, vol.14, issue.Pt 1, pp.1416-1424, 2015.
DOI : 10.1002/hep.27360

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320676

Y. Liu, J. Li, J. Chen, Y. Li, W. Wang et al., ABSTRACT, Journal of Virology, vol.89, issue.4, pp.2287-2300, 2015.
DOI : 10.1128/JVI.02760-14

URL : https://hal.archives-ouvertes.fr/hal-00129638

H. Wang and W. S. Ryu, Hepatitis B Virus Polymerase Blocks Pattern Recognition Receptor Signaling via Interaction with DDX3: Implications for Immune Evasion, PLoS Pathogens, vol.18, issue.8, 2010.
DOI : 10.1371/journal.ppat.1000986.s003

URL : http://doi.org/10.1371/journal.ppat.1000986

A. Boltjes, Z. M. Groothuismink, G. W. Van-oord, H. L. Janssen, A. M. Woltman et al., Monocytes from Chronic HBV Patients React In Vitro to HBsAg and TLR by Producing Cytokines Irrespective of Stage of Disease, PLoS ONE, vol.83, issue.229, p.97006
DOI : 10.1371/journal.pone.0097006.s001

R. A. De-groen, J. Hou, G. W. Van-oord, Z. M. Groothuismink, M. Van-der-heide et al., NK cell phenotypic and functional shifts coincide with specific clinical phases in the natural history of chronic HBV infection, Antiviral Research, vol.140, pp.18-24, 2017.
DOI : 10.1016/j.antiviral.2017.01.007

J. Martinet, T. Dufeu-duchesne, J. Bruder-costa, S. Larrat, A. Marlu et al., Altered Functions of Plasmacytoid Dendritic Cells and Reduced Cytolytic Activity of Natural Killer Cells in Patients With Chronic HBV Infection, Gastroenterology, vol.143, issue.6, pp.1586-1596, 2012.
DOI : 10.1053/j.gastro.2012.08.046

E. T. Tjwa, R. Zoutendijk, G. W. Van-oord, L. L. Boeijen, J. G. Reijnders et al., Similar frequencies, phenotype and activation status of intrahepatic NK cells in chronic HBV patients after long-term treatment with tenofovir disoproxil fumarate (TDF), Antiviral Research, vol.132, pp.70-75, 2016.
DOI : 10.1016/j.antiviral.2016.05.016

E. Van-der-aa, S. I. Buschow, P. J. Biesta, H. L. Janssen, and A. M. Woltman, The Effect of Chronic Hepatitis B Virus Infection on BDCA3+ Dendritic Cell Frequency and Function, PLOS ONE, vol.42, issue.1, p.161235, 2016.
DOI : 10.1371/journal.pone.0161235.s005

L. J. Pallett, U. S. Gill, A. Quaglia, L. V. Sinclair, M. Jover-cobos et al., Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells, Nature Medicine, vol.43, issue.6, pp.591-600, 2015.
DOI : 10.1053/j.gastro.2012.06.009

Z. Fang, J. Li, X. Yu, D. Zhang, G. Ren et al., Polarization of Monocytic Myeloid-Derived Suppressor Cells by Hepatitis B Surface Antigen Is Mediated via ERK/IL-6/STAT3 Signaling Feedback and Restrains the Activation of T Cells in Chronic Hepatitis B Virus Infection, The Journal of Immunology, vol.195, issue.10, pp.4873-4883, 2015.
DOI : 10.4049/jimmunol.1501362

M. Swiecki and M. Colonna, The multifaceted biology of plasmacytoid dendritic cells, Nature Reviews Immunology, vol.9, issue.8, pp.471-485
DOI : 10.1038/nri3865

A. M. Woltman, M. L. Op-den-brouw, P. J. Biesta, C. C. Shi, and H. L. Janssen, Hepatitis B Virus Lacks Immune Activating Capacity, but Actively Inhibits Plasmacytoid Dendritic Cell Function, PLoS ONE, vol.25, issue.1, p.15324, 2011.
DOI : 10.1371/journal.pone.0015324.t002

URL : http://doi.org/10.1371/journal.pone.0015324

J. Hong and Z. J. Gong, regulatory T cells compared with healthy patients, Hepatology Research, vol.166, issue.4, pp.362-373, 2008.
DOI : 10.1038/374546a0

Y. Xu, Y. Hu, B. Shi, X. Zhang, J. Wang et al., HBsAg inhibits TLR9-mediated activation and IFN-?? production in plasmacytoid dendritic cells, Molecular Immunology, vol.46, issue.13, pp.2640-2646, 2009.
DOI : 10.1016/j.molimm.2009.04.031

M. Gilliet, W. Cao, and Y. J. Liu, Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases, Nature Reviews Immunology, vol.204, issue.8, pp.594-606, 2008.
DOI : 10.1038/nri2358

E. Van-der-aa, N. Van-montfoort, and A. M. Woltman, BDCA3+CLEC9A+ human dendritic cell function and development, Seminars in Cell & Developmental Biology, vol.41, pp.39-48, 2015.
DOI : 10.1016/j.semcdb.2014.05.016

N. Isorce, B. Testoni, M. Locatelli, J. Fresquet, M. Rivoire et al., Antiviral activity of various interferons and pro-inflammatory cytokines in non-transformed cultured hepatocytes infected with hepatitis B virus, Antiviral Research, vol.130, pp.36-45, 2016.
DOI : 10.1016/j.antiviral.2016.03.008

Y. Xia, D. Stadler, J. Lucifora, F. Reisinger, D. Webb et al., Interferon-?? and Tumor Necrosis Factor-?? Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis, Gastroenterology, vol.150, issue.1, pp.194-205, 2016.
DOI : 10.1053/j.gastro.2015.09.026

P. Fisicaro, C. Valdatta, C. Boni, M. Massari, C. Mori et al., Early kinetics of innate and adaptive immune responses during hepatitis B virus infection, Gut, vol.58, issue.7, pp.974-982, 2009.
DOI : 10.1136/gut.2008.163600

C. S. Guy, P. M. Mulrooney-cousins, N. D. Churchill, and T. Michalak, Intrahepatic Expression of Genes Affiliated with Innate and Adaptive Immune Responses Immediately after Invasion and during Acute Infection with Woodchuck Hepadnavirus, Journal of Virology, vol.82, issue.17, pp.8579-8591, 2008.
DOI : 10.1128/JVI.01022-08

G. J. Webster, S. Reignat, M. K. Maini, S. A. Whalley, G. S. Ogg et al., Incubation Phase of Acute Hepatitis B in Man: Dynamic of Cellular Immune Mechanisms, Hepatology, vol.30, issue.5, pp.1117-1124, 2000.
DOI : 10.1053/jhep.2000.19324

B. Oliviero, S. Varchetta, E. Paudice, G. Michelone, M. Zaramella et al., Natural Killer Cell Functional Dichotomy in Chronic Hepatitis B and Chronic Hepatitis C Virus Infections, Gastroenterology, vol.137, issue.3, pp.1151-1160, 2009.
DOI : 10.1053/j.gastro.2009.05.047

URL : http://hdl.handle.net/2434/223217

D. Peppa, L. Micco, A. Javaid, P. T. Kennedy, A. Schurich et al., Blockade of Immunosuppressive Cytokines Restores NK Cell Antiviral Function in Chronic Hepatitis B Virus Infection, PLoS Pathogens, vol.97, issue.12, p.1001227, 2010.
DOI : 10.1371/journal.ppat.1001227.s004

A. Okazaki, N. Hiraga, M. Imamura, C. N. Hayes, M. Tsuge et al., Severe necroinflammatory reaction caused by natural killer cell-mediated Fas/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse, Hepatology, vol.34, issue.2, pp.555-566, 2012.
DOI : 10.1002/hep.25651

Z. Zhang, S. Zhang, Z. Zou, J. Shi, J. Zhao et al., Hypercytolytic activity of hepatic natural killer cells correlates with liver injury in chronic hepatitis B patients, Hepatology, vol.46, issue.1, pp.73-85, 2011.
DOI : 10.1002/hep.23977

B. Rehermann, Natural Killer Cells in Viral Hepatitis, Cellular and Molecular Gastroenterology and Hepatology, vol.1, issue.6, pp.578-588
DOI : 10.1016/j.jcmgh.2015.09.004

A. Boltjes, D. Movita, A. Boonstra, and A. M. Woltman, The role of Kupffer cells in hepatitis B and hepatitis C virus infections, Journal of Hepatology, vol.61, issue.3, pp.660-671, 2014.
DOI : 10.1016/j.jhep.2014.04.026

K. J. Brempelis and I. N. Crispe, Infiltrating monocytes in liver injury and repair, Clinical & Translational Immunology, vol.87, issue.11, 2016.
DOI : 10.1161/CIRCRESAHA.111.253377

URL : http://doi.org/10.1038/cti.2016.62

G. Sitia, M. Iannacone, R. Aiolfi, M. Isogawa, N. Van-rooijen et al., Kupffer Cells Hasten Resolution of Liver Immunopathology in Mouse Models of Viral Hepatitis, PLoS Pathogens, vol.107, issue.Unit 1.10, p.1002061, 2011.
DOI : 10.1371/journal.ppat.1002061.s011

L. Xu, W. Yin, R. Sun, H. Wei, and Z. Tian, Kupffer cell-derived IL-10 plays a key role in maintaining humoral immune tolerance in hepatitis B virus-persistent mice, Hepatology, vol.52, issue.2, pp.443-452, 2014.
DOI : 10.1002/hep.26668

H. Ohashi and T. Kiyohara, Interleukin-1 and tumor necrosis factor-alpha trigger restriction of hepatitis B virus infection via a cytidine deaminase activation-induced cytidine deaminase (AID), J. Biol. Chem, vol.288, pp.31715-31727, 2013.

F. Heymann, J. Peusquens, I. Ludwig-portugall, M. Kohlhepp, C. Ergen et al., Liver inflammation abrogates immunological tolerance induced by Kupffer cells, Hepatology, vol.60, issue.012, pp.279-291, 2015.
DOI : 10.1002/hep.27793

M. Li, R. Sun, L. Xu, W. Yin, Y. Chen et al., T Cell Exhaustion via Hepatitis B Core Antigen???TLR2 Interactions in Mice, The Journal of Immunology, vol.195, issue.7, pp.3100-3109, 2015.
DOI : 10.4049/jimmunol.1500839

J. Y. Zhang, Z. S. Zou, A. Huang, Z. Zhang, J. L. Fu et al., Hyper-Activated Pro-Inflammatory CD16+ Monocytes Correlate with the Severity of Liver Injury and Fibrosis in Patients with Chronic Hepatitis B, PLoS ONE, vol.38, issue.3, p.17484, 2011.
DOI : 10.1371/journal.pone.0017484.t001

V. Christen, F. Duong, C. Bernsmeier, D. Sun, M. Nassal et al., Inhibition of Alpha Interferon Signaling by Hepatitis B Virus, Journal of Virology, vol.81, issue.1, pp.159-165, 2007.
DOI : 10.1128/JVI.01292-06

M. Lutgehetmann, T. Bornscheuer, T. Volz, L. Allweiss, J. H. Bockmann et al., Hepatitis B Virus Limits Response of Human Hepatocytes to Interferon-?? in Chimeric Mice, Gastroenterology, vol.140, issue.7, pp.2074-2083, 2011.
DOI : 10.1053/j.gastro.2011.02.057

L. Belloni, L. Allweiss, F. Guerrieri, N. Pediconi, T. Volz et al., IFN-?? inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome, Journal of Clinical Investigation, vol.122, issue.2, pp.529-537, 2012.
DOI : 10.1172/JCI58847DS1

J. Lucifora, Y. Xia, F. Reisinger, K. Zhang, D. Stadler et al., Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA, Science, vol.105, issue.19, pp.1221-1228, 2014.
DOI : 10.1073/pnas.0707882105

L. Micco, D. Peppa, E. Loggi, A. Schurich, L. Jefferson et al., Differential boosting of innate and adaptive antiviral responses during pegylated-interferon-alpha therapy of chronic hepatitis B, Journal of Hepatology, vol.58, issue.2, pp.225-233, 2013.
DOI : 10.1016/j.jhep.2012.09.029

A. Penna, D. Laccabue, I. Libri, T. Giuberti, S. Schivazappa et al., Peginterferon-?? does not improve early peripheral blood HBV-specific T-cell responses in HBeAg-negative chronic hepatitis, Journal of Hepatology, vol.56, issue.6, pp.1239-1246, 2012.
DOI : 10.1016/j.jhep.2011.12.032

C. Boni, D. Laccabue, P. Lampertico, T. Giuberti, M. Vigano et al., Restored Function of HBV-Specific T Cells After Long-term Effective Therapy With Nucleos(t)ide Analogues, Gastroenterology, vol.143, issue.4, pp.963-973, 2012.
DOI : 10.1053/j.gastro.2012.07.014

R. Thimme and M. Dandri, Dissecting the divergent effects of interferon-alpha on immune cells: Time to rethink combination therapy in chronic hepatitis B?, Journal of Hepatology, vol.58, issue.2, pp.205-209, 2013.
DOI : 10.1016/j.jhep.2012.11.007

P. Marcellin, S. H. Ahn, X. Ma, F. A. Caruntu, W. Y. Tak et al., Combination of Tenofovir Disoproxil Fumarate and Peginterferon ??-2a Increases Loss of Hepatitis B Surface Antigen in Patients With Chronic Hepatitis B, Gastroenterology, vol.150, issue.1, pp.134-144, 2016.
DOI : 10.1053/j.gastro.2015.09.043

H. L. Chan, S. H. Ahn, T. T. Chang, C. Y. Peng, D. Wong et al., Peginterferon lambda for the treatment of HBeAg-positive chronic hepatitis B: A randomized phase 2b study (LIRA-B), Journal of Hepatology, vol.64, issue.5, pp.1011-1019, 2016.
DOI : 10.1016/j.jhep.2015.12.018

N. Isorce, J. Lucifora, F. Zoulim, and D. Durantel, Immune-modulators to combat hepatitis B virus infection: From IFN-?? to novel investigational immunotherapeutic strategies, Antiviral Research, vol.122, pp.69-81, 2015.
DOI : 10.1016/j.antiviral.2015.08.008

M. Isogawa, M. D. Robek, Y. Furuichi, and F. Chisari, Toll-Like Receptor Signaling Inhibits Hepatitis B Virus Replication In Vivo, Journal of Virology, vol.79, issue.11, pp.7269-7272, 2005.
DOI : 10.1128/JVI.79.11.7269-7272.2005

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1112123

J. Lucifora, S. Maadadi, O. Floriot, S. Daffis, S. Fletcher et al., P0535 : Direct antiviral effects of various pattern recognition receptor (PRR) agonists in HBV-replicating hepatocytes, Journal of Hepatology, vol.62, pp.515-516, 2015.
DOI : 10.1016/S0168-8278(15)30742-X

X. Zhang, Z. Ma, H. Liu, J. Liu, Z. Meng et al., Role of Toll-like receptor 2 in the immune response against hepadnaviral infection, Journal of Hepatology, vol.57, issue.3, pp.522-528, 2012.
DOI : 10.1016/j.jhep.2012.05.004

D. Durantel and F. Zoulim, Interplay between hepatitis B virus and TLR2-mediated innate immune responses: Can restoration of TLR2 functions be a new therapeutic option?, Journal of Hepatology, vol.57, issue.3, pp.486-489
DOI : 10.1016/j.jhep.2012.06.019

L. R. Huang, D. Wohlleber, F. Reisinger, C. N. Jenne, R. L. Cheng et al., Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+ T cells and successful immunotherapy against chronic viral liver infection, Nature Immunology, vol.12, issue.6, pp.574-583, 2013.
DOI : 10.1371/journal.pone.0025109

S. Lv, J. Wang, S. Dou, X. Yang, X. Ni et al., Nanoparticles encapsulating hepatitis B virus cytosine-phosphate-guanosine induce therapeutic immunity against HBV infection, Hepatology, vol.204, issue.2, pp.385-394, 2014.
DOI : 10.1002/hep.26654

Z. Meng, X. Zhang, R. Pei, E. Zhang, T. Kemper et al., Combination therapy including CpG oligodeoxynucleotides and entecavir induces early viral response and enhanced inhibition of viral replication in a woodchuck model of chronic hepadnaviral infection, Antiviral Research, vol.125, pp.14-24, 2016.
DOI : 10.1016/j.antiviral.2015.11.001

H. Dansako, Y. Ueda, N. Okumura, S. Satoh, M. Sugiyama et al., The cyclic GMP-AMP synthetase-STING signaling pathway is required for both the innate immune response against HBV and the suppression of HBV assembly, FEBS Journal, vol.97, issue.463, pp.144-156, 2016.
DOI : 10.1111/febs.13563

F. Guo, Y. Han, X. Zhao, J. Wang, F. Liu et al., STING Agonists Induce an Innate Antiviral Immune Response against Hepatitis B Virus, Antimicrobial Agents and Chemotherapy, vol.59, issue.2, pp.1273-1281, 2015.
DOI : 10.1128/AAC.04321-14

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335851

J. He, R. Hao, D. Liu, X. Liu, S. Wu et al., Inhibition of hepatitis B virus replication by activation of the cGAS-STING pathway, J. Gen. Virol, vol.97, pp.3368-3378, 2016.

K. E. Korolowicz, R. P. Iyer, S. Czerwinski, M. Suresh, J. Yang et al., Antiviral Efficacy and Host Innate Immunity Associated with SB 9200 Treatment in the Woodchuck Model of Chronic Hepatitis B, PLOS ONE, vol.71, issue.12, p.161313, 2016.
DOI : 10.1371/journal.pone.0161313.s002

R. E. Lanford, B. Guerra, D. Chavez, L. Giavedoni, V. L. Hodara et al., GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees, Gastroenterology, vol.144, issue.7, pp.1508-1517, 2013.
DOI : 10.1053/j.gastro.2013.02.003

S. Menne, D. B. Tumas, K. H. Liu, L. Thampi, D. Aldeghaither et al., Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B, Journal of Hepatology, vol.62, issue.6, pp.1237-1245, 2015.
DOI : 10.1016/j.jhep.2014.12.026

Z. Ye and S. Pflanz, The oral Toll-Like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection, J. Hepatol, vol.63, pp.320-328, 2015.

E. Lawitz, D. Gruener, T. Marbury, J. Hill, L. Webster et al., Safety, pharmacokinetics and pharmacodynamics of the oral Toll-like receptor 7 agonist GS-9620 in treatment-naive patients with chronic hepatitis C, Antiviral Therapy, vol.20, issue.7, pp.699-708, 2015.
DOI : 10.3851/IMP2845

C. H. Ries, M. A. Cannarile, S. Hoves, J. Benz, K. Wartha et al., Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy, Cancer Cell, vol.25, issue.6, pp.846-859, 2014.
DOI : 10.1016/j.ccr.2014.05.016

URL : http://doi.org/10.1016/j.ccr.2014.05.016

R. P. Tobin, D. Davis, K. R. Jordan, and M. D. Mccarter, The clinical evidence for targeting human myeloid-derived suppressor cells in cancer patients, Journal of Leukocyte Biology, p.2017
DOI : 10.1189/jlb.5VMR1016-449R

J. Martinet, V. Leroy, T. Dufeu-duchesne, S. Larrat, M. J. Richard et al., Plasmacytoid dendritic cells induce efficient stimulation of antiviral immunity in the context of chronic hepatitis B virus infection, Hepatology, vol.206, issue.Suppl, pp.1706-1718, 2012.
DOI : 10.1002/hep.25879

A. C. Lee, A. P. Dhillon, S. P. Reid, E. P. Thi, J. R. Phelps et al., Exploring combination therapy for curing HBV: Preclinical studies with capsid inhibitor AB-423 and a sirna agent, Hepatology, vol.64, pp.1740-122, 2016.

N. Mani, A. G. Cole, A. Ardzinski, D. W. Cai, A. Cuconati et al., The HBV capsid inhibitor AB-423 exhibits a dual mode of action and displays additive/synergistic effects in in vitro combination studies, Hepatology, vol.64, pp.123-124, 2016.