PET Imaging for Initial Staging and Therapy Assessment in Multiple Myeloma Patients

Clément Bailly 1, 2 Rodolphe Leforestier 1 Bastien Jamet 1 Thomas Carlier 2, 1 Mickael Bourgeois 2, 1 François Guérard 2 Cyrille Touzeau 1 Philippe Moreau 1 Michel Chérel 3, 2 Françoise Kraeber-Bodéré 2, 1, 3 Caroline Bodet-Milin 2, 1, *
* Auteur correspondant
1 NANTES - Médecine Nucléaire - Département de Médecine Nucléaire
2 CRCINA - Centre de recherche de Cancérologie et d'Immunologie / Nantes - Angers
3 ICO Nantes - Institut de cancérologie de l'Ouest - Nantes
Abstract : Multiple myeloma (MM) is a hematological neoplasm characterized by the clonal proliferation of malignant plasma cells in the bone marrow. MM results in diffuse or focal bone infiltration and extramedullary lesions. Over the past two decades, advances have been made with regard to the diagnosis, staging, treatment, and imaging of MM. Computed tomography (CT) and magnetic resonance imaging (MRI) are currently recommended as the most effective imaging modalities at diagnostic. Yet, recent data from the literature suggest that positron emission tomography combined with computed tomography (PET/CT) using 18 F-deoxyglucose (FDG) is a promising technique for initial staging and therapeutic monitoring in this pathology. This paper reviews the recent advances as well as the potential place of a more specific radiopharmaceutical in MM.
Keywords : therapeutic evaluation solitary plasmacytoma PET/CT multiple myeloma
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Article dans une revue
International Journal of Molecular Sciences, MDPI, 2017, 18 (2), pii: E445. 〈10.3390/ijms18020445〉
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Clément Bailly, Rodolphe Leforestier, Bastien Jamet, Thomas Carlier, Mickael Bourgeois, et al.. PET Imaging for Initial Staging and Therapy Assessment in Multiple Myeloma Patients. International Journal of Molecular Sciences, MDPI, 2017, 18 (2), pii: E445. 〈10.3390/ijms18020445〉. 〈inserm-01500327〉

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